The Role of Secondary Epileptogenesis in Human Epilepsy

Drug-resistant temporal lobe epilepsy due to cavernous malformations

“…According to some evidence, the rationale for removing apparently normal brain tissue that is distant from a lesion site can be related to the concept of "secondary epileptogenesis," that is, the development of epileptic activity remote from the original lesional focus. 19,20 Experimental studies support the hypothesis that reiteration of ictal activity may promote the formation of new recurrent excitatory circuits through phenomena of axonal sprouting and synaptic reorganization. 12,16,30 Our findings strengthen these hypotheses.…”

Drug-resistant temporal lobe epilepsy due to cavernous malformations

“…According to some evidence, the rationale for removing apparently normal brain tissue that is distant from a lesion site can be related to the concept of "secondary epileptogenesis," that is, the development of epileptic activity remote from the original lesional focus. 19,20 Experimental studies support the hypothesis that reiteration of ictal activity may promote the formation of new recurrent excitatory circuits through phenomena of axonal sprouting and synaptic reorganization. 12,16,30 Our findings strengthen these hypotheses.…”

Seizure freedom after laser amygdalohippocampotomy guided by bilateral responsive neurostimulation in pediatric epilepsy: illustrative case

“…Contralateral interictal temporal discharges most likely represented a not fully autonomous seizure focus, or area of secondary epileptogenesis. 18 , 22 , 23 …”

Anterior corpus callosotomy in multistep invasive monitoring and surgery for atonic seizures

“…Frank Morell first described the concept of secondary epileptogenesis in experimental animal models. A primary epileptogenic region generated epileptogenic potentials in a secondary epileptic region (histologically normal) via neuronal connections with the primary area [23] , [24] , [25] , [26] . However, in human epilepsy, this concept remains controversial.…”

Drug-resistant temporal lobe epilepsy due to cavernous malformations

“…According to some evidence, the rationale for removing apparently normal brain tissue that is distant from a lesion site can be related to the concept of "secondary epileptogenesis," that is, the development of epileptic activity remote from the original lesional focus. 19,20 Experimental studies support the hypothesis that reiteration of ictal activity may promote the formation of new recurrent excitatory circuits through phenomena of axonal sprouting and synaptic reorganization. 12,16,30 Our findings strengthen these hypotheses.…”

Seizure freedom after laser amygdalohippocampotomy guided by bilateral responsive neurostimulation in pediatric epilepsy: illustrative case

“…Contralateral interictal temporal discharges most likely represented a not fully autonomous seizure focus, or area of secondary epileptogenesis. 18 , 22 , 23 …”

Anterior corpus callosotomy in multistep invasive monitoring and surgery for atonic seizures

“…Frank Morell first described the concept of secondary epileptogenesis in experimental animal models. A primary epileptogenic region generated epileptogenic potentials in a secondary epileptic region (histologically normal) via neuronal connections with the primary area [23] , [24] , [25] , [26] . However, in human epilepsy, this concept remains controversial.…”

Drug-resistant temporal lobe epilepsy due to cavernous malformations

“…According to some evidence, the rationale for removing apparently normal brain tissue that is distant from a lesion site can be related to the concept of "secondary epileptogenesis," that is, the development of epileptic activity remote from the original lesional focus. 19,20 Experimental studies support the hypothesis that reiteration of ictal activity may promote the formation of new recurrent excitatory circuits through phenomena of axonal sprouting and synaptic reorganization. 12,16,30 Our findings strengthen these hypotheses.…”

Seizure freedom after laser amygdalohippocampotomy guided by bilateral responsive neurostimulation in pediatric epilepsy: illustrative case

“…Contralateral interictal temporal discharges most likely represented a not fully autonomous seizure focus, or area of secondary epileptogenesis. 18 , 22 , 23 …”

Anterior corpus callosotomy in multistep invasive monitoring and surgery for atonic seizures

“…Frank Morell first described the concept of secondary epileptogenesis in experimental animal models. A primary epileptogenic region generated epileptogenic potentials in a secondary epileptic region (histologically normal) via neuronal connections with the primary area [23] , [24] , [25] , [26] . However, in human epilepsy, this concept remains controversial.…”