The role of RENAL, PADUA, C-index, CSA nephrometry systems in predicting ipsilateral renal function after partial nephrectomy

Hsieh, Po-Fan; Huang, Chi‐Ping; Chang, Chao Hsiang; Wu, Hsi‐Chin; Yang, Che Rei; Wang, Yu Ping; Hsieh, Po Fan

doi:10.1186/s12894-019-0504-2

Cited by 13 publications

(26 citation statements)

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“…In addition, tumor contact surface area has a greater ability to predict post-operative renal function than R.E.N.A.L. and PADUA [11,19]. SPARE includes components such as radius (R) and exophytic rate (E), which is similar to tumor contact surface area [11].…”

Section: Discussionmentioning

confidence: 99%

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

Huang

Chang

et al. 2020

BMC Urol

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Background Pentafecta is a major goal in the era of partial nephrectomy (PN). Simplified PADUA REnal (SPARE) nephrometry system was developed to evaluate the complexity of tumor. However, the predictive ability in pentafecta of SPARE system is yet to be determined. The aim of this study was to externally validate the applicability of SPARE nephrometry system in predicting pentafecta achievement after partial nephrectomy, and to examine inter-observer concordance. Methods We retrospectively reviewed data of 207 consecutive patients who underwent PN between January 2012 and August 2018 at a tertiary referral center. We obtained SPARE, R.E.N.A.L., and PADUA scores and evaluated correlations among the nephrometries and surgical outcomes including pentafecta by Spearman test. Logistic regression analysis was used to identify independent predictors of pentafecta outcomes. We compared the nephrometries to determine the predictive ability of achieving pentafecta using receiver operating characteristic curve analysis. Fleiss’ generalized kappa was used to assessed interobserver variation in the SPARE system. Results Based on the SPARE system, 120, 74, and 13 patients were stratified into low-risk, intermediate-risk, and high-risk groups, respectively. Regarding the individual components of pentafecta, there were significant differences in the complication rate (p = 0.03), ischemia time (p < 0.001), and percent change of eGFR (p < 0.001) among the three risk groups. In addition, higher tumor complexity was significantly associated with a lower achievement rate of pentafecta (p = 0.01). In Spearman correlation tests, SPARE nephrometry was correlated with ischemia time (ρ:0.37, p < 0.001), operative time (ρ:0.28, p < 0.001), complication rate (ρ:0.34, p < 0.001), percent change of eGFR (ρ:0.34, p < 0.001), and progression of chronic kidney disease stage (ρ:0.17, p = 0.02). Multivariate analysis revealed that SPARE significantly affected pentafecta (OR: 0.67, p < 0.001). In ROC curve analysis, SPARE showed fair predictive ability in the achievement pentafecta (AUC: 0.71). The predictive ability of pentafecta was similar between nephrometries (SPARE vs. R.E.N.A.L., p = 0.78; SPARE vs. PADUA, p = 0.66). The interobserver concordance of SPARE was excellent (Kappa: 0.82, p = 0.03). Conclusions SPARE system was a predictive factor of surgical outcomes after PN. This refined nephrometry had similar predictive abilities for pentafecta achievement compared with R.E.N.A.L. and PADUA.

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Section: Discussionmentioning

confidence: 99%

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

Huang

Chang

et al. 2020

BMC Urol

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“…In addition, tumor contact surface area has a greater ability to predict post-operative renal function than R.E.N.A.L. and PADUA [11,16]. SPARE includes components such as radius (R) and exophytic rate (E), which is similar to tumor contact surface area [11].…”

Section: Discussionmentioning

confidence: 99%

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

Huang

Chang

et al. 2020

Preprint

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BackgroundPentafecta is a major goal in the era of partial nephrectomy (PN). Simplified PADUA REnal (SPARE) nephrometry system was developed to evaluate the complexity of tumor. However, the predictive ability in pentafecta of SPARE system is yet to be determined. The aim of this study was to externally validate the applicability of SPARE nephrometry system in predicting pentafecta achievement after partial nephrectomy, and to examine inter-observer concordance.MethodsWe retrospectively reviewed data of 207 consecutive patients who underwent PN between January 2012 and August 2018 at a tertiary referral center. We obtained SPARE, R.E.N.A.L., and PADUA scores and evaluated correlations among the nephrometries and surgical outcomes including pentafecta by Spearman test. Logistic regression analysis was used to identify independent predictors of pentafecta outcomes. We compared the nephrometries to determine the predictive ability of achieving pentafecta using receiver operating characteristic curve analysis. Fleiss’ generalized kappa was used to assessed interobserver variation in the SPARE system.ResultsBased on the SPARE system, 120, 74, and 13 patients were stratified into low-risk, intermediate-risk, and high-risk groups, respectively. Regarding the individual components of pentafecta, there were significant differences in the complication rate (p=0.03), ischemia time (p<0.001), and percent change of eGFR (p<0.001) among the three risk groups. In addition, higher tumor complexity was significantly associated with a lower achievement rate of pentafecta (p=0.01). In Spearman correlation tests, SPARE nephrometry was correlated with ischemia time (ρ:0.37, p<0.001), operative time (ρ:0.28, p<0.001), complication rate (ρ:0.34, p<0.001), percent change of eGFR (ρ:0.34, p<0.001), and progression of chronic kidney disease stage (ρ:0.17, p=0.02). Multivariate analysis revealed that SPARE significantly affected pentafecta (OR: 0.66, p=0.004). In ROC curve analysis, SPARE showed fair predictive ability in the achievement pentafecta (AUC: 0.73). The predictive ability of pentafecta was similar between nephrometries (SPARE vs. R.E.N.A.L., p=0.92; SPARE vs. PADUA, p=0.57). The interobserver concordance of SPARE was excellent (Kappa: 0.82, p=0.03).ConclusionsSPARE system was a predictive factor of surgical outcomes after PN. This refined nephrometry had similar predictive abilities for pentafecta achievement compared with R.E.N.A.L. and PADUA.

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“…В исследованиях, касающихся изолированного анализа функции оперированной почки, отмечалась корреляция как общей суммы баллов по шкале R.E.N.A.L., так и отдельных нефрометрических показателей с данными динамической нефросцинтиграфии, проведенной в различные сроки после резекции [43,[56][57][58]. [59][60][61][62][63][64][65].…”

Section: A б вunclassified

The R.E.N.A.L. nephrometry score in radiologist’s practice

Рубцова¹,

Крянева²,

Golbits³

et al. 2021

Onkourologiâ

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В последние десятилетия за счет достижений в области медицинской визуализации и улучшения алгоритмов диагностического поиска отмечается тенденция к увеличению частоты выявления опухолей почек небольших размеров, для которых возможно проведение органосохраняющего лечения. Для прогнозирования потенциальной сложности выполнения резекции и снижения степени субъективности при выборе объема и методики хирургического вмешательства разными группами исследователей было предложено значительное число концепций оценки новообразований почек. Нефрометрическая шкала R.E.N.A.L., разработанная одной из первых, но сохраняющая свою актуальность, позволяет, исходя из совокупности анатомических особенностей, структурированно и стандартизированно характеризовать опухоли почек. В статье представлена методика оценки каждого из параметров, входящих в состав представленной нефрометрической системы, а также приведен краткий обзор литературы ее прогностической значимости.

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The role of RENAL, PADUA, C-index, CSA nephrometry systems in predicting ipsilateral renal function after partial nephrectomy

Cited by 13 publications

References 30 publications

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

External validation of the Simplified PADUA REnal (SPARE) nephrometry system in predicting surgical outcomes after partial nephrectomy

The R.E.N.A.L. nephrometry score in radiologist’s practice

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