2020
DOI: 10.1080/00222895.2020.1738992
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Abstract: The predominant role of the primary motor cortex (M1) in motor execution is well acknowledged. However, additional roles of M1 are getting evident in humans owing to advances in noninvasive brain stimulation (NIBS) techniques. This review collates such studies in humans and proposes that M1 also plays a key role in higher cognitive processes. The review commences with the studies that have investigated the nature of connectivity of M1 with other cortical regions in light of studies based on NIBS. The review th… Show more

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Cited by 61 publications
(40 citation statements)
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“…Increased excitability within MI, specifically, has also been shown in adults with OCD ( 54 ), including in a recent study that found increased MI excitability during Go/No-Go Task performance in adult OCD that was associated with an earlier (childhood) onset of OCD symptoms ( 55 ). Although the MI finding in the present study was not linked to clinical symptoms, a prior study suggested that increased activation in motor cortex in children and adults with OCD may be linked to increased difficulty in inhibiting responses and potentially related to compulsive behavior ( 56 ). Importantly, MI has been a successful neural target for low-frequency (inhibitory) brain stimulation in clinical trials aiming to treat OCD symptoms in adults that have not responded to medication or behavioral treatments ( 57 ).…”
Section: Discussioncontrasting
confidence: 79%
“…Increased excitability within MI, specifically, has also been shown in adults with OCD ( 54 ), including in a recent study that found increased MI excitability during Go/No-Go Task performance in adult OCD that was associated with an earlier (childhood) onset of OCD symptoms ( 55 ). Although the MI finding in the present study was not linked to clinical symptoms, a prior study suggested that increased activation in motor cortex in children and adults with OCD may be linked to increased difficulty in inhibiting responses and potentially related to compulsive behavior ( 56 ). Importantly, MI has been a successful neural target for low-frequency (inhibitory) brain stimulation in clinical trials aiming to treat OCD symptoms in adults that have not responded to medication or behavioral treatments ( 57 ).…”
Section: Discussioncontrasting
confidence: 79%
“…The foci in the left precentral gyrus is the site for primary motor cortex. Although the predominant role of this region is motor execution, more recent studies propose that it also plays a key role in higher cognitive processes, such as attention and movement inhibition 85 . The left primary motor cortex potentially contributed to controlling hand movements in our right-handed participants who use their right hand to push the response box button.…”
Section: Discussionmentioning
confidence: 99%
“…Increased excitability within MI, specifically, has also been shown in adults with OCD (Khedr et al, 2016), including in a study that found increased MI excitability during Go/No-Go Task performance in OCD that was also associated with an earlier (childhood) onset of OCD symptoms (Kang et al, 2019). A prior study suggested that increased activation in motor cortex in children and adults with OCD may be linked to increased difficulty in inhibiting responses and potentially related to compulsive behavior (Bhattacharjee et al, 2020). Importantly, MI has been a successful neural target for low-frequency (inhibitory) brain stimulation clinical trials aiming to treat OCD symptoms in adults that have not responded to medication or behavioural treatments (Rapinesi et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…However, magnetoencephalography (MEG) may offer some advantages over fMRI as it records neuromagnetic activity and enables tracking of neural activation with high spatial and temporal resolution (Ahlfors and Mody, 2019). Additionally, MEG can characterize the frequencies in which large groups of neurons fire during a particular task, including oscillations in the: delta (0.5-3 Hz), theta (4-7 Hz), alpha (8)(9)(10)(11)(12), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and gamma (30+ Hz) bandwidths (Todd et al, 2014). Thus far, very few studies have used MEG to study neural response in OCD.…”
Section: Introductionmentioning
confidence: 99%