The Role of Platelet-Rich Plasma in Foot and Ankle Surgery

Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study

“…Gandhi et al [39] measured the levels of PDGF and TGF beta in fracture hematoma of patients who had sustained fresh fractures of foot and ankle. They observed the absence of these factors in cases of nonunion.…”

Distally Based Lateral Hemi-soleus Muscle Flap for Osseous and Soft Tissue Defects as a Complication of Total Ankle Replacement: A Case Report

“…Using a distally based hemisoleus muscle flaps for soft tissue reconstruction was first described by Tobin in 1985 [2]. Although there were concerns regarding the reliability of these muscle flaps, recent improvements in surgical technique with meticulous dissection to preserve the vascular supply to the muscle flap have improved the efficacy of a local muscle flap in the lower extremity.…”

“…By utilizing only one half of the muscle, it not only retains its function as a plantar-flexor and a stabilizer but it also increases the arc of rotation of the flap, and allows easy accessibility for coverage of wound defects [5]. Recent studies have shown supplementation of the flap and skin graft with bone marrow aspirate (BMA), platelet-rich plasma (PRP), and platelet-poor plasma (PPP) can further increase the success of tissue regeneration and increase its uses in foot and ankle surgery [2,5].…”

Application of Bioreactor Concept and Modeling Techniques to Bone Regeneration and Augmentation Treatments

“…In addition, the whole blood scaffold acts as an extracellular matrix, promoting cell growth and accelerating the regenerative process through the influence of GFs present in the blood clot itself [100]. Thus, the blood clot formed spontaneously in the defect is sufficient to achieve bone healing and regeneration.…”