2018
DOI: 10.3390/antiox7120172
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Abstract: Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses glutathione and π glutathione S-transferase to complete its catalytic cycle. Prdx6 is also the only peroxiredoxin capable of reducing phospholipid hydroperoxides through its glutathione peroxidase (Gpx) activity. In addition to its peroxidase activity, Prdx6 expresses acidic calcium-independent phospholipase A2 (aiPLA2) and lysophos… Show more

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Cited by 67 publications
(52 citation statements)
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References 110 publications
(141 reference statements)
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“…A well-established example of such, is NOX2-dependent activation of tolllike receptor (TLR) pathway promoting antibacterial autophagy [51]. Other examples of PLA 2 -dependent signaling include arachidonic acid pathway [52] and nuclear factor kappa B (NF-κB) pathway [53], which are up and downregulated by PRDX6 level, respectively. In summary, we hypothesize that the beneficence of PRDX6 overexpression against Aβ pathology is owed both to its anti-oxidative function, which increases oxidative stress endurance and allows for a more robust penetration of Aβ deposits by astrocytes and for the signaling function of PLA 2 by which astrocytes circuitously can modulate the activity of plaque-associated microglia.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A well-established example of such, is NOX2-dependent activation of tolllike receptor (TLR) pathway promoting antibacterial autophagy [51]. Other examples of PLA 2 -dependent signaling include arachidonic acid pathway [52] and nuclear factor kappa B (NF-κB) pathway [53], which are up and downregulated by PRDX6 level, respectively. In summary, we hypothesize that the beneficence of PRDX6 overexpression against Aβ pathology is owed both to its anti-oxidative function, which increases oxidative stress endurance and allows for a more robust penetration of Aβ deposits by astrocytes and for the signaling function of PLA 2 by which astrocytes circuitously can modulate the activity of plaque-associated microglia.…”
Section: Discussionmentioning
confidence: 99%
“…However, how TREM2 expression is triggered during microglia activation and how it is sustained effecting microglia phagocytic phenotype remains unclear [59]. TREM2 activity is suppressed by activation of the NF-κB [59] pathway, which also is inversely regulated by PRDX6 expression level [53]. TREM2 also is stimulated by a set of specific ligands, including apoE [4,59], which plaque content directly correlates with PRDX6 expression.…”
Section: Discussionmentioning
confidence: 99%
“…Another highly down-regulated gene in WN and WH sh was prdx6 (qPCR validated), which encodes for Peroxiredoxin-6. This protein is important for phospholipid homeostasis, lipid peroxidation repair, and in ammatory signaling [139]. The up-regulation of prdx6 upon heat stress to protect the cell from oxidative stress has been reported in other marine animals [140,141].…”
Section: Oxidative Stressmentioning
confidence: 91%
“…These processes include the metabolism by cytochrome P450 of natural and xenobiotic compounds including drugs, food products, also cell signaling, circadian clock regulation, etc. [ 224 , 225 , 226 ].…”
Section: Chelator Protein Interactions and Free Radical Pathologymentioning
confidence: 99%