The role of oxidative damage in metal carcinogenicity

Determinants of urinary 8‐hydroxy‐2′‐deoxyguanosine in Chinese children with acute leukemia

“…Urinary Cr has been shown to be associated with urinary 8-OHdG from linear regression analysis in children with leukemia under aged 3 years. Our results are consistent with multiple previous reports: occupational exposure to Cr induced elevated urinary 8-OHdG levels (Kuo et al, 2003); childhood leukemia risk associated with exposure to Cr was increased, not significantly though (Infante-Rivard et al, 2001); hydroxyl radical (OH) formation from the reaction of chelated Cr with H 2 O 2 was involved in the toxicity and oxidative DNA damage (Shi and Dalal, 1990;Kasprzak, 1991).…”

Determinants of urinary 8‐hydroxy‐2′‐deoxyguanosine in Chinese children with acute leukemia

“…Urinary Cr has been shown to be associated with urinary 8-OHdG from linear regression analysis in children with leukemia under aged 3 years. Our results are consistent with multiple previous reports: occupational exposure to Cr induced elevated urinary 8-OHdG levels (Kuo et al, 2003); childhood leukemia risk associated with exposure to Cr was increased, not significantly though (Infante-Rivard et al, 2001); hydroxyl radical (OH) formation from the reaction of chelated Cr with H 2 O 2 was involved in the toxicity and oxidative DNA damage (Shi and Dalal, 1990;Kasprzak, 1991).…”

Cytogenetic Alteration Induced by Nickel and Chromium in Human Blood Cultures and its Amelioration by Curcumin

“…These free radicals also inhibit the DNA repair enzymes followed by cell cycle regulatory enzymes proteins leading to low cell proliferation. Chromium and nickel compounds further interact with DNA repair processes that lead to an enhancement of genotoxicity in combination with a variety of DNA damaging agents (Klein et al 1991;Kasprzak 1991). Millosevic et al (2005) showed that the newborns exposed to environmental pollutant containing Ni and Cr illustrate high frequency of micronuclei, which supports our finding .…”

Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen.

“…Discussion This study was carried out to examine the genotoxic effects of nickel in cultured cells, to evaluate the protective effects of magnesium against nickel toxicity, and finally to find the effects of metals on reactive oxygen formation. Much evidence supports a close relationship between nickel toxicity and carcinogenicity, which involves the formation of reactive oxygen species inside cells (7,14,15). We have clearly demonstrated in this study that the genotoxicity of Ni3S2 assessed by micronuclei formation and DNA-protein cross-link formation was markedly reduced by the magnesium carbonate.…”

Determinants of urinary 8‐hydroxy‐2′‐deoxyguanosine in Chinese children with acute leukemia

“…Urinary Cr has been shown to be associated with urinary 8-OHdG from linear regression analysis in children with leukemia under aged 3 years. Our results are consistent with multiple previous reports: occupational exposure to Cr induced elevated urinary 8-OHdG levels (Kuo et al, 2003); childhood leukemia risk associated with exposure to Cr was increased, not significantly though (Infante-Rivard et al, 2001); hydroxyl radical (OH) formation from the reaction of chelated Cr with H 2 O 2 was involved in the toxicity and oxidative DNA damage (Shi and Dalal, 1990;Kasprzak, 1991).…”

Cytogenetic Alteration Induced by Nickel and Chromium in Human Blood Cultures and its Amelioration by Curcumin

“…These free radicals also inhibit the DNA repair enzymes followed by cell cycle regulatory enzymes proteins leading to low cell proliferation. Chromium and nickel compounds further interact with DNA repair processes that lead to an enhancement of genotoxicity in combination with a variety of DNA damaging agents (Klein et al 1991;Kasprzak 1991). Millosevic et al (2005) showed that the newborns exposed to environmental pollutant containing Ni and Cr illustrate high frequency of micronuclei, which supports our finding .…”

Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen.

“…Discussion This study was carried out to examine the genotoxic effects of nickel in cultured cells, to evaluate the protective effects of magnesium against nickel toxicity, and finally to find the effects of metals on reactive oxygen formation. Much evidence supports a close relationship between nickel toxicity and carcinogenicity, which involves the formation of reactive oxygen species inside cells (7,14,15). We have clearly demonstrated in this study that the genotoxicity of Ni3S2 assessed by micronuclei formation and DNA-protein cross-link formation was markedly reduced by the magnesium carbonate.…”

Determinants of urinary 8‐hydroxy‐2′‐deoxyguanosine in Chinese children with acute leukemia

“…Urinary Cr has been shown to be associated with urinary 8-OHdG from linear regression analysis in children with leukemia under aged 3 years. Our results are consistent with multiple previous reports: occupational exposure to Cr induced elevated urinary 8-OHdG levels (Kuo et al, 2003); childhood leukemia risk associated with exposure to Cr was increased, not significantly though (Infante-Rivard et al, 2001); hydroxyl radical (OH) formation from the reaction of chelated Cr with H 2 O 2 was involved in the toxicity and oxidative DNA damage (Shi and Dalal, 1990;Kasprzak, 1991).…”

Cytogenetic Alteration Induced by Nickel and Chromium in Human Blood Cultures and its Amelioration by Curcumin

“…These free radicals also inhibit the DNA repair enzymes followed by cell cycle regulatory enzymes proteins leading to low cell proliferation. Chromium and nickel compounds further interact with DNA repair processes that lead to an enhancement of genotoxicity in combination with a variety of DNA damaging agents (Klein et al 1991;Kasprzak 1991). Millosevic et al (2005) showed that the newborns exposed to environmental pollutant containing Ni and Cr illustrate high frequency of micronuclei, which supports our finding .…”

Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen.

“…Discussion This study was carried out to examine the genotoxic effects of nickel in cultured cells, to evaluate the protective effects of magnesium against nickel toxicity, and finally to find the effects of metals on reactive oxygen formation. Much evidence supports a close relationship between nickel toxicity and carcinogenicity, which involves the formation of reactive oxygen species inside cells (7,14,15). We have clearly demonstrated in this study that the genotoxicity of Ni3S2 assessed by micronuclei formation and DNA-protein cross-link formation was markedly reduced by the magnesium carbonate.…”