The role of neurogenesis in neurorepair after ischemic stroke

Marques, Bruno Lemes; Carvalho, Gustavo; Freitas, Elis M.M.; Chiareli, Raphaela Almeida; Barbosa, Thiago G.; Araújo, Armani G.P. Di; Nogueira, Yanley Lucio; Ribeiro, Raul Izidoro; Parreira, Ricardo Cambraia; Vieira, Mariana Sousa; Resende, Rodrigo R.; Gomez, Renato Santiago; Oliveira‐Lima, Onésia Cristina; Pinto, Mauro Cunha Xavier

doi:10.1016/j.semcdb.2018.12.003

Cited by 68 publications

(51 citation statements)

References 149 publications

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“…The SGZ forms a narrow layer between the granule cell layer and hilus of the dentate gyrus in the hippocampus and is accepted to be one of the stem-cell-containing niches of the adult brain [51]. What exactly triggers neurogenesis is not fully established, but proliferation of NSCs in the SVZ and SGZ has, for instance, been observed as a consequence of ischemic stroke, leading to cell migration towards the lesion to contribute to repair [52,53]. Thus, the SVZ and SGZ microenvironments are thought to provide the appropriate conditions for NSCs to proliferate, while also allowing for the differentiation into the relevant neurons via several rounds of asynchronous proliferation.…”

Section: Cellular and Molecular Life Sciencesmentioning

confidence: 99%

“…Recently, chronic mild hypoxia has been linked to adult neurogenesis in the hippocampus [148], while the deletion of HIF1α in mouse neural cells led to hydrocephaly, reduced number of NSCs and impaired spatial memory [149]. Along this line, work on stroke patients suggests that ischemia leads to the proliferation of NSCs in the SVZ and SGZ of the dentate gyrus, migration towards the lesion, and integration into the damaged area [52,53]. Thus, oxygen sensing is clearly an important feature during neurogenesis, and its regulation is not only required for NSCs to exit their quiescent state but also to commit to their final cell linage.…”

Section: Redox State and Rosmentioning

confidence: 99%

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Metabolic regulation of neurodifferentiation in the adult brain

Maffezzini

Calvo‐Garrido

Wredenberg

et al. 2020

Cell. Mol. Life Sci.

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Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation.

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Section: Cellular and Molecular Life Sciencesmentioning

confidence: 99%

Section: Redox State and Rosmentioning

confidence: 99%

Metabolic regulation of neurodifferentiation in the adult brain

Maffezzini

Calvo‐Garrido

Wredenberg

et al. 2020

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Endogenous neurogenesis involves a complex process beginning with the proliferation of NSCs, followed by the differentiation of NSCs into new neurons . Epigenetic modification has emerged as a critical mechanism regulating gene expression in a temporal and spatial manner during proliferation and differentiation of NSCs .…”

Section: Introductionmentioning

confidence: 99%

Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke

Ling

Zhang

Xia

et al. 2019

J Cellular Molecular Medi

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Endogenous neurogenesis holds promise for brain repair and long‐term functional recovery after ischaemic stroke. However, the effects of exosomes from human urine‐derived stem cells (USC‐Exos) in neurogenesis remain unclear. This study aimed to investigate whether USC‐Exos enhanced neurogenesis and promoted functional recovery in brain ischaemia. By using an experimental stroke rat model, we found that intravenous injection of USC‐Exos enhanced neurogenesis and alleviated neurological deficits in post‐ischaemic stroke rats. We used neural stem cells (NSCs) subjected to oxygen‐glucose deprivation/reoxygenation (OGD/R) as an in vitro model of ischaemic stroke. The in vitro results suggested that USC‐Exos promoted both proliferation and neuronal differentiation of NSCs after OGD/R. Notably, a further mechanism study revealed that the pro‐neurogenesis effects of USC‐Exos may be partially attributed to histone deacetylase 6 (HDAC6) inhibition via the transfer of exosomal microRNA‐26a (miR‐26a). Taken together, this study indicates that USC‐Exos can be used as a novel promising strategy for brain ischaemia, which highlights the application of USC‐Exos.

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“…The post‐stroke neurogenesis is an avenue to repair damaged brain tissue due to ischemia . However, the endogenous neuroregenerative response to ischemia is insufficient to neurological recovery . Neural stem cell (NSC) transplantation is regarded as one of stem cell‐based therapies for neurological disorders including stroke.…”

Section: Introductionmentioning

confidence: 99%

Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation

et al. 2020

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Neural stem cell (NSC) transplantation has emerged as a promising approach for the treatment of neurological disorders such as cerebral ischemia. As the majority of newly generated cells from exogenous NSCs fail to integrate into the ischemic brain and establish functional synaptic networks, NSC transplantation for ischemic stroke experiences limited neurological function recovery. Augment of endogenous neurite growth in the process of NSC differentiation is an avenue to promote synaptic networks. Phosphatase and tensin homolog (PTEN), a tumor suppressor, has been established to regulate axon growth in the adult central nervous system. The aim of this study was to explore the role of PTEN on neurite growth during NSC differentiation. Our results revealed that the protein expression of PTEN was significantly increased during NSC differentiation, whereas the expression of phosphorylated S6 ribosomal (p‐S6R) was markedly decreased. Small interfering RNA knockdown of PTEN in NSCs can accelerate neurite outgrowth during NSC differentiation. These results indicated a remarkable effect of PTEN inhibition on neuronal process after NSC differentiation, and identified a novel route to promote endogenous neurite growth in differentiated NSCs, which may facilitate the application of NSC transplantation in ischemic stroke.

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The role of neurogenesis in neurorepair after ischemic stroke

Cited by 68 publications

References 149 publications

Metabolic regulation of neurodifferentiation in the adult brain

Metabolic regulation of neurodifferentiation in the adult brain

Exosomes from human urine‐derived stem cells enhanced neurogenesis via miR‐26a/HDAC6 axis after ischaemic stroke

Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation

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