The Role of Natural Products in the Prevention and Treatment of Multiple Sclerosis

Shamsizadeh, Ali; Roohbakhsh, Ali; Ayoobi, Fatemeh; Moghaddamahmadi, A.

doi:10.1016/b978-0-12-805298-3.00025-6

Cited by 16 publications

(9 citation statements)

References 109 publications

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“…In sum, all three structural isomers of elemenes reported here employed His439 residue to interact with AChE and this interesting finding suggests their applications in aromatherapy for AD. In consistent with experimental data (Shamsizadeh et al 2017), our ADMET prediction showed that elemenes can be crossed from GIT and BBB (Table 1).…”

Section: Resultssupporting

confidence: 89%

Computational insight to putative anti-acetylcholinesterase activity of Commiphora myrrha (Nees), Engler, Burseraceae: a lessen of archaeopharmacology from Mesopotamian Medicine I

Hussein

Karimi

Yousofvand

2019

In Silico Pharmacol.

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Commiphora spp., Burseraceae family and their resinous matter, myrrh, are used in Mesopotamian medicine as fragrance or antiinsectant. Based on in vitro, leaves, bark, and resin methyl alcohol extract of C. myrrha showed similar inhibitory effects of 17.00, 26.00, and 29.33% for acetylcholinesterase (AChE) as compared to eserine, respectively. The ADMET properties and putative anticholinesterase activity of phytochemicals of myrrh were computationally predicted using in silico tools. Phytochemicals of C. myrrha had acceptable binding affinity (BA) towards principal sites of AChE ranging from − 5.8 (m-cresol) to − 10.5 (abietic acid) kcal/mol. In this regard, all terpenoid compounds (25 out of 28) of myrrh were dual inhibitors since they hydrophobically interacted with both catalytic triad and peripheral anionic site (PAS) of AChE while alpha-terpineol, elemol, and eugenol employed hydrogen bonds with AChE. Cuscohygrine as a pyrrolidine alkaloid has been docked with AChE through hydrogen bonds with PAS and through hydrophobic interactions with catalytic triad thereby we initially proposed it as dual inhibitor of AChE. M-cresol as a methylphenol has been loosely docked with AChE via hydrogen bond and would be a hit molecule for further drug synthesis. This study not only confirmed archaeopharmacological applications of myrrh as antiinsectant or nootropics but also offered an array of terpenoid compounds, cuscohygrine, and m-cresol as a good starting point for hit-to-lead-to-drug optimization phase in synthesis of phyto-nootropics and ecofriendly insecticides.

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Section: Resultssupporting

confidence: 89%

Computational insight to putative anti-acetylcholinesterase activity of Commiphora myrrha (Nees), Engler, Burseraceae: a lessen of archaeopharmacology from Mesopotamian Medicine I

Hussein

Karimi

Yousofvand

2019

In Silico Pharmacol.

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“…Animals treated with Andrographis paniculata exhibited reduced inflammation, reduced scarring, increased angiogenesis, and an increased number of collagen fibres in healed wounds [76]. Andrographolide, a bicyclic diterpenoid isolated from the leaves of Andrographis paniculata , has been formally evaluated in clinical trials and shown to have positive effects on several autoimmune disorders [77].…”

Section: Traditional Use Of Medical Plants In Wound Healingmentioning

confidence: 99%

Wound Healing and the Use of Medicinal Plants

Shedoeva

Leavesley

Upton

et al. 2019

Evidence-Based Complementary and Alternative Medicine

273

164

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Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating “granulation tissue” rich in extracellular matrix proteins and supporting the growth of new blood vessels. Ultimately, this is remodelled over an extended period, returning the injured tissue to a state similar to that before injury. Dysregulation in any phase of the wound healing cascade delays healing and may result in various skin pathologies, including nonhealing, or chronic ulceration. Indigenous and traditional medicines make extensive use of natural products and derivatives of natural products and provide more than half of all medicines consumed today throughout the world. Recognising the important role traditional medicine continues to play, we have undertaken an extensive survey of literature reporting the use of medical plants and plant-based products for cutaneous wounds. We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including Centella asiatica, Curcuma longa, and Paeonia suffruticosa, which are popular wound healing products used by several cultures and ethnic groups. The popularity and evidence of continued use clearly indicates that there are still lessons to be learned from traditional practices. Hidden in the myriad of natural products and derivatives from natural products are undescribed reagents, unexplored combinations, and adjunct compounds that could have a place in the contemporary therapeutic inventory.

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“…Owing to these limitations, an increasing number of patients have started to turn to natural products to relieve symptoms of RA and related ailments [ 67 ], with over 36% of adults in the USA using complementary and alternative (CAM) therapies [ 68 ]. Natural products have been studied extensively in multiple different ailments such as cancer [ 69 ], infectious diseases [ 70 ], and autoimmunity [ 71 , 72 , 73 , 74 , 75 ]. However, difficulties in evaluating the efficacy of these products as well as inadequate information about their mechanism of action are among the reasons for skepticism from both the public and professional communities [ 76 , 77 ].…”

Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Dudics

Langan

Meka

et al. 2018

IJMS

122

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Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. We discuss here the basic features of RA pathogenesis; the commonly used animal models of RA; the mainstream drugs used for RA; the use of well-characterized natural products possessing anti-arthritic activity; the application of nanoparticles for efficient delivery of such products; and the interplay between dietary products and the host microbiome for maintenance of health and disease induction. We believe that with several advances in the past decade in the characterization and functional studies of natural products, the stage is set for widespread clinical testing and/or use of these products for the treatment of RA and other diseases.

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The Role of Natural Products in the Prevention and Treatment of Multiple Sclerosis

Cited by 16 publications

References 109 publications

Computational insight to putative anti-acetylcholinesterase activity of Commiphora myrrha (Nees), Engler, Burseraceae: a lessen of archaeopharmacology from Mesopotamian Medicine I

Computational insight to putative anti-acetylcholinesterase activity of Commiphora myrrha (Nees), Engler, Burseraceae: a lessen of archaeopharmacology from Mesopotamian Medicine I

Wound Healing and the Use of Medicinal Plants

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

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