The role of mycobacteria in Crohn's disease

Thompson, D.E.

doi:10.1099/00222615-41-2-74

Cited by 89 publications

(53 citation statements)

References 187 publications

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“…Later subsequent studies demonstrated that the isolates were genetically identical to strains of M. paratuberculosis originated from cattle, and were able to develop paratuberculosis after oral administration to infant goats (Van Kruiningen et al, 1986). Similar isolation of the organism from Crohn's disease patients was described by Chiodini (1989), Pavlík et al (1994), and Thompson (1994). M. paratuberculosis has also been cultured in the laboratory from humans with chronic inflammation of the intestine of the Crohn's disease type, but in very rare cases (Coloe et al, 1986;Gitnick et al, 1989;Thorel, 1989;Haagsma et al, 1991).…”

Section: A Possible Role In Crohn's Diseasementioning

confidence: 53%

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

Ayele¹,

Macháčková²,

Pavlík³

2001

Vet. Med. - Czech

104

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Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) infects domestic cattle, sheep, goats, deer, camelids and wild ruminants leading to chronic enteritis known as paratuberculosis (Johne’s disease). The infection is chronic, progressive and unresponsive to treatment. Most infected animals do not develop clinical disease but may excrete the bacteria. Clinically sick animals suffer emaciation and in some species diarrhoea, followed by eventual death. During the course of the disease, excretion of M. paratuberculosis in faeces and milk occurs, and the organism spreads through the blood and lymph vessels of infected animals to multiple internal organs. The infection disseminates to both the female and male reproductive organs. Though M. paratuberculosis is not classified as a human pathogen, current opinions on the possible role of this mycobacteria in public health is discussed. This article attempts to review the ways and circumstances by which M. paratuberculosis is transmitted within an animal population and the importance of the disease on animal production. Published reports concerning the transmission and epidemiology of the disease are reviewed herein, and preventive and control measures are summarised.

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Section: A Possible Role In Crohn's Diseasementioning

confidence: 53%

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

Ayele¹,

Macháčková²,

Pavlík³

2001

Vet. Med. - Czech

104

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“…Interestingly, M. paratuberculosis causes Johne's disease, an intestinal disorder in ruminants such as cattle, horse and goat that resembles CD both clinically and histologically (34). Other studies reported increased titers of antibodies to M. paratuberculosis antigens in CD patients (35)(36)(37). Nevertheless, neither clinical nor immunohistochemical studies have provided convincing evidence for a role for mycobacteria in CD (36,38,39).…”

Section: Bacterial Agents In Crohn's Diseasementioning

confidence: 91%

The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease

2004

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“…The high lipid content of the bacterial cell wall provides the bacteria with resistance to acid and alkali. 8 In 1959, a classification scheme for Mycobacterium was developed (Runyon). This scheme enabled mycobacteria to be classified according to rate of growth (slow or rapid) and production of pigment (yellow or orange).…”

Section: Discussionmentioning

confidence: 99%

Atypical mycobacterial infection in post laparoscopy surgical wounds: our observations and review of literature

Kumar

Samarasam

2017

Int Surg J

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Background: Nontuberculous mycobacteria (NTM) are a rare cause of chronic surgical infection in humans. These infections are commonly seen in the setting of laparoscopic surgery, due to poor sterilization techniques. This case series analyses the clinical features and management of patients with biopsy proven NTM infection, with a review of the current literature.Methods: Patients with chronic surgical site infections admitted to our surgical unit, over a 5-year period from January 2008 to December 2012 were analyzed in this study. A total of 24 patients with biopsy proven NTM were included. The clinical details, management protocol is discussed.Results: A total of 24 patients were analysed. Most of our patients were females (n=16) and this infection was most commonly seen following laparoscopic cholecystectomy (n=10). The symptoms were usually benign but persistent watery or purulent discharge. Mycobacterium fortuitum and Mycobacterium chelonae were the predominant organisms isolated. All patients in this series were treated with extensive surgical debridement and long-term antibiotics. A multidrug antibiotic regimen consisting of Ciprofloxacin, Clarithromycin and Amikacin was used. All of our patients showed good response to treatment during stay and recurrence was seen in 3 patients who had delayed healing wounds.Conclusions: NTM is not an uncommon infection and can occur following laparoscopic or open surgical procedures. Improper sterilization and reuse of laparoscopic or open instruments accounts for the majority of the cases. When laparoscopic instruments are reused, following strict sterilization protocols is necessary to prevent this infection. When established, this infection should be treated aggressively with adequate surgical debridement, followed by long term antibiotics.

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The role of mycobacteria in Crohn's disease

Cited by 89 publications

References 187 publications

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease

Atypical mycobacterial infection in post laparoscopy surgical wounds: our observations and review of literature

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