The role of microRNAs (miRNA) in circadian rhythmicity

Pegoraro, Mirko; Tauber, Eran

doi:10.1007/s12041-008-0073-8

Cited by 47 publications

(37 citation statements)

References 75 publications

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“…Up to now, researchers have made many attempts to identify clock-associated miRNAs and their function in the circadian rhythm (Pegoraro and Tauber, 2008). Cheng et al have revealed that miR-219 and miR-132 were shown to regulate the circadian clock in the mouse suprachiasmatic nucleus (Cheng et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm

Sung

Lee

et al. 2009

Exp Mol Med

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To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as the pair both elements of which show circadian expression patterns and the sequence-based target relationship of which can be predicted. Circadian initiators, Clock and Bmal1, showed inversely correlated circadian expression patterns against their corresponding miRNAs, miR-181d and miR-191, targeting them. In contrast, circadian suppressors, Per, Cry, CKIe and Rev-erba, exhibited positively correlated circadian expression patterns to their corresponding miRNAs. Genomic location analysis revealed that intronic region showed higher abundance of cyclic than non-cyclic miRNAs targeting circadian genes while other (i.e., 3'-UTR, exon and intergenic) regions showed no difference. It is suggested that miRNAs are involved in the regulation of peripheral circadian rhythm in mouse liver by modulating Clock:Bmal1 complex. Identifying specific miRNAs and their targets that are critically involved in circadian rhythm will provide a better understanding of the regulation of circadian-clock system.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm

Sung

Lee

et al. 2009

Exp Mol Med

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“…Alternatively, Xbsx could be continuously transcribed, but inhibitory factors present during the daytime might degrade or destabilize its mRNA. Putative inhibitory factors could be represented by rhythmically expressed deadenilases (similar to Nocturnin but with an opposite phase of expression) (23) and micro-RNAs (24).…”

Section: Xbsx Is Expressed In a Cyclical Manner In Pineal Photoreceptormentioning

confidence: 99%

Xenopus Bsxlinks daily cell cycle rhythms and pineal photoreceptor fate

D'Autilia

Broccoli

Barsacchi

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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In the developing central nervous system, the cell cycle clock plays a crucial role in determining cell fate specification. A second clock, the circadian oscillator, generates daily rhythms of cell cycle progression. Although these two clocks interact, the mechanisms linking circadian cell cycle progression and cell fate determination are still poorly understood. A convenient system to address this issue is the pineal organ of lower vertebrates, which contains only two neuronal types, photoreceptors and projection neurons. In particular, photoreceptors constitute the core of the pineal circadian system, being able to transduce daily light inputs into the rhythmical production of melatonin. However, the genetic program leading to photoreceptor fate largely remains to be deciphered. Here, we report a previously undescribed function for the homeobox gene Bsx in controlling pineal proliferation and photoreceptor fate in Xenopus. We show that Xenopus Bsx (Xbsx) is expressed rhythmically in postmitotic photoreceptor precursors, reaching a peak during the night, with a cycle that is complementary to the daily rhythms of S-phase entry displayed by pineal cells. Xbsx knockdown results in increased night levels of pineal proliferation, whereas activation of a GR-Xbsx protein flattens the daily rhythms of S-phase entry to the lowest level. Furthermore, evidence is presented that Xbsx is necessary and sufficient to promote a photoreceptor fate. Altogether, these data indicate that Xbsx plays a dual role in contributing to shape the profile of the circadian cell cycle progression and in the specification of pineal photoreceptors, thus acting as a unique link between these two events.he correct balance between proliferation and differentiation is crucial to ensure the appropriate size of the different areas of the central nervous system and the proportionate generation of a remarkable variety of neuronal and glial cell types. In particular, in the retina and cerebral cortex, cell cycle exit of progenitors is strictly coordinated with cell fate specification following a temporal order that involves different competence stages (1, 2). An additional level of complexity in the control of cell proliferation was recently discovered with the observation that the circadian clock, which regulates metabolic and physiological rhythms, also generates daily rhythms of cell cycle progression. Indeed, several cell cycle regulators, including c-myc, cyclin D1, and Wee-1, are regulated in a circadian manner (3, 4). This results in S-phase entry of many cells at the end of the day or during the night, an evolutionarily conserved phenomenon that has been proposed to represent an adaptation of ancestral unicellular animals to reduce the risk of UV-induced DNA damage (5, 6).Although significant progress has been made in understanding how the circadian clock and the cell cycle interact, it is still unclear what the molecular links are between the circadian control of cell proliferation and the generation of specific cell types.A suitable system in...

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“…MicroRNAs were also identified as molecular elements that help in the regulation of the circadian machine (178,179).…”

Section: Connecting the Whole Tale: Mrna Surveillance Under Differentmentioning

confidence: 99%

RNA Surveillance: Molecular Approaches in Transcript Quality Control and their Implications in Clinical Diseases

Moraes

2009

Mol Med

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Production of mature mRNAs that encode functional proteins involves highly complex pathways of synthesis, processing and surveillance. At numerous steps during the maturation process, the mRNA transcript undergoes scrutiny by cellular quality control machinery. This extensive RNA surveillance ensures that only correctly processed mature mRNAs are translated and precludes production of aberrant transcripts that could encode mutant or possibly deleterious proteins. Recent advances in elucidating the molecular mechanisms of mRNA processing have demonstrated the existence of an integrated network of events, and have revealed that a variety of human diseases are caused by disturbances in the well-coordinated molecular equilibrium of these events. From a medical perspective, both loss and gain of function are relevant, and a considerable number of different diseases exemplify the importance of the mechanistic function of RNA surveillance in a cell. Here, mechanistic hallmarks of mRNA processing steps are reviewed, highlighting the medical relevance of their deregulation and how the understanding of such mechanisms can contribute to the development of therapeutic strategies.

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The role of microRNAs (miRNA) in circadian rhythmicity

Cited by 47 publications

References 75 publications

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm

Xenopus Bsxlinks daily cell cycle rhythms and pineal photoreceptor fate

RNA Surveillance: Molecular Approaches in Transcript Quality Control and their Implications in Clinical Diseases

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