The Role of MicroRNAs in Lung Cancer: Implications for Diagnosis and Therapy

Naeli, Parisa; Yousefi, Fatemeh; Ghasemi, Younes; Savardashtaki, Amir; Mirzaei, Hamed

doi:10.2174/1566524019666191001113511

Cited by 48 publications

(29 citation statements)

References 142 publications

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“…Growing trend of documents show that various cancers such as oral cancers might be modulated in under epigenetic condition via histone demethylases or micro-RNAs [15,61,[109][110][111][112][113][114][115][116][117][118]. One of the groups of histone demethylases epigenetically regulated transcribing gene via removal of the histone methylation marks [119].…”

Section: Epigenetic Regulators and Oral Cancer Stem Cells Histone Demmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

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Section: Epigenetic Regulators and Oral Cancer Stem Cells Histone Demmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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“…Non-coding RNAs (ncRNAs) comprise a huge part of human genome and are involved in various molecular pathways and processes [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. They are divided into two characteristic groups: house-keeping and regulatory molecules [ 49 ].…”

Section: Micrornasmentioning

confidence: 99%

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

et al. 2020

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Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) and -2 (ZEB2) are molecules that play vital roles in signaling pathways to ensure the survival of tumor cells, particularly through enhancing cell proliferation, promoting cell migration and invasion, and triggering drug resistance. Importantly, ZEB proteins are regulated by microRNAs (miRs). In this review, we demonstrate the impact that miRs have on cancer therapy, through their targeting of ZEB proteins. MiRs are able to act as onco-suppressor factors and inhibit the malignancy of tumor cells through ZEB1/2 down-regulation. This can lead to an inhibition of epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, miRs are able to inhibit ZEB1/2-mediated drug resistance and immunosuppression. Additionally, we explore the upstream modulators of miRs such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as these regulators can influence the inhibitory effect of miRs on ZEB proteins and cancer progression.

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“…Briefly, miRs belong to non-coding RNAs (ncRNAs) from the subcategory of regulatory RNAs [ 76 , 77 , 78 ]. Although miRs comprise a large section of genome and are not translated into proteins, they exert regulatory effects on important cellular events, such as proliferation, migration, and so on [ 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ]. In terms of regulation of the PTEN signaling pathway, miRs have demonstrated great potential.…”

Section: Pten and Gastric Cancermentioning

confidence: 99%

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

et al. 2020

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Cancer is one of the life-threatening disorders that, in spite of excellent advances in medicine and technology, there is no effective cure for. Surgery, chemotherapy, and radiotherapy are extensively applied in cancer therapy, but their efficacy in eradication of cancer cells, suppressing metastasis, and improving overall survival of patients is low. This is due to uncontrolled proliferation of cancer cells and their high migratory ability. Finding molecular pathways involved in malignant behavior of cancer cells can pave the road to effective cancer therapy. In the present review, we focus on phosphatase and tensin homolog (PTEN) signaling as a tumor-suppressor molecular pathway in gastric cancer (GC). PTEN inhibits the PI3K/Akt pathway from interfering with the migration and growth of GC cells. Its activation leads to better survival of patients with GC. Different upstream mediators of PTEN in GC have been identified that can regulate PTEN in suppressing growth and invasion of GC cells, such as microRNAs, long non-coding RNAs, and circular RNAs. It seems that antitumor agents enhance the expression of PTEN in overcoming GC. This review focuses on aforementioned topics to provide a new insight into involvement of PTEN and its downstream and upstream mediators in GC. This will direct further studies for evaluation of novel signaling networks and their targeting for suppressing GC progression.

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The Role of MicroRNAs in Lung Cancer: Implications for Diagnosis and Therapy

Cited by 48 publications

References 142 publications

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

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