The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress

Miguel, Verónica; Cui, Julia Yue; Daimiel, Lidia; Espinosa‐Díez, Cristina; Fernández‐Hernando, Carlos; Kavanagh, Terrance J.; Lamas, Santiago

doi:10.1089/ars.2017.7175

Cited by 64 publications

(48 citation statements)

References 234 publications

(224 reference statements)

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“…epigenetic or microRNA) changes of signalling cascades leading to an imbalance between ROS production and detoxification. 30 Also central effects have been described consisting of autonomic imbalance and hypothalamic–pituitary–adrenal axis activation that is partially based on the lung arc reflex as well as potential crossing of the blood–brain barrier by reactive gases, ultrafine particles and soluble, PM surface-bound compounds such as transition metals, endotoxins and reactive (photo-activated) quinones/aldehydes ( Figure 3 ). 26 , 31 …”

Section: Pathophysiological Insights Into Mechanisms Of Air Pollutionmentioning

confidence: 99%

Effects of gaseous and solid constituents of air pollution on endothelial function

Münzel

Gori

Al‐Kindi

et al. 2018

European Heart Journal

299

174

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Ambient air pollution is a leading cause of non-communicable disease globally. The largest proportion of deaths and morbidity due to air pollution is now known to be due to cardiovascular disorders. Several particulate and gaseous air pollutants can trigger acute events (e.g. myocardial infarction, stroke, heart failure). While the mechanisms by which air pollutants cause cardiovascular events is undergoing continual refinement, the preponderant evidence support rapid effects of a diversity of pollutants including all particulate pollutants (e.g. course, fine, ultrafine particles) and gaseous pollutants such as ozone, on vascular function. Indeed alterations in endothelial function seem to be critically important in transducing signals and eventually promoting cardiovascular disorders such as hypertension, diabetes, and atherosclerosis. Here, we provide an updated overview of the impact of particulate and gaseous pollutants on endothelial function from human and animal studies. The evidence for causal mechanistic pathways from both animal and human studies that support various hypothesized general pathways and their individual and collective impact on vascular function is highlighted. We also discuss current gaps in knowledge and evidence from trials evaluating the impact of personal-level strategies to reduce exposure to fine particulate matter (PM2.5) and impact on vascular function, given the current lack of definitive randomized evidence using hard endpoints. We conclude by an exhortation for formal inclusion of air pollution as a major risk factor in societal guidelines and provision of formal recommendations to prevent adverse cardiovascular effects attributable to air pollution.

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Section: Pathophysiological Insights Into Mechanisms Of Air Pollutionmentioning

confidence: 99%

Effects of gaseous and solid constituents of air pollution on endothelial function

Münzel

Gori

Al‐Kindi

et al. 2018

European Heart Journal

299

174

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“…epigenetic or microRNA) changes of signalling cascades leading to an imbalance between ROS production and detoxification. 30 Also central effects have been described consisting of autonomic imbalance and hypothalamic-pituitaryadrenal axis activation that is partially based on the lung arc reflex as well as potential crossing of the blood-brain barrier by reactive gases, ultrafine particles and soluble, PM surface-bound compounds such as transition metals, endotoxins and reactive (photo-activated) quinones/aldehydes (Figure 3). 26,31 Animal studies A variety of different approaches have been employed to study the effects of air pollution in the experimental context.…”

Section: Pathophysiological Insights Into Mechanisms Of Air Pollutionmentioning

confidence: 99%

Should a fistula first policy be revisited in elderly haemodialysis patients?

Lomonte

Basile

Mitra

et al. 2018

Nephrology Dialysis Transplantation

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Life-sustaining haemodialysis requires a durable vascular access (VA) to the circulatory system. The ideal permanent VA must provide longevity for use with minimal complication rate and supply sufficient blood flow to deliver the prescribed dialysis dosage. Arteriovenous fistulas (AVFs) have been endorsed by many professional societies as the VA of choice. However, the high prevalence of comorbidities, particularly diabetes mellitus, peripheral vascular disease and arterial hypertension in elderly people, usually make VA creation more difficult in the elderly. Many of these patients may have an insufficient vasculature for AVF maturation. Furthermore, many AVFs created prior to the initiation of haemodialysis may never be used due to the competing risk of death before dialysis is required. As such, an arteriovenous graft and, in some cases, a central venous catheter, become a valid alternative form of VA. Consequently, there are multiple decision points that require careful reflection before an AVF is placed in the elderly. The traditional metrics of access patency, failure and infection are now being seen in a broader context that includes procedure burden, quality of life, patient preferences, morbidity, mortality and cost. This article of the European Dialysis (EUDIAL) Working Group of ERA-EDTA critically reviews the current evidence on VA in elderly haemodialysis patients and concludes that a pragmatic patient-centred approach is mandatory, thus considering the possibility that the AVF first approach should not be an absolute.

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“…Currently, studies on miRNAs and hearing loss have demonstrated that these miRNAs can be used as potential biomarkers to indicate NIHL [15,23]. In a study involving miRNA-15a-1 and miRNA-18a in the development of the ear structure of zebrafish, it was found that the number of hair cells in the deformed body decreased, and the inner ear structure was abnormal [24].…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

Wang

Guo

et al. 2020

Biochemistry Research International

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Objectives. e purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3′UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene. Methods.We conducted a case-control study involving 1040 cases and 1060 controls. e effects of SNPs on XPO5 expression were studied by genotyping, real-time polymerase chain reaction (qPCR), cell transfection, and the dual-luciferase reporter assay. Results.We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene. e rs2257082 AG/GG carriers have special connection to an increased risk of noise-induced hearing loss compared to the AA carriers. e rs11077TG/GG carriers had a significantly increased association with NIHL susceptibility than the TT carriers. ere was a higher risk of NIHL in the XPO5 gene rs7755135 CC carriers than in the TT carriers. No statistically significant correlation was obtained with respect to SNPrs1106841. Functional experiments showed that the rs11077 change might inhibit the interaction between miRNAs (miRNA-4763-5p, miRNA-5002-3p, and miRNA-617) and XPO5, with rs11077G allele resulting in overexpression of XPO5. Conclusion. e genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.

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The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress

Cited by 64 publications

References 234 publications

Effects of gaseous and solid constituents of air pollution on endothelial function

Effects of gaseous and solid constituents of air pollution on endothelial function

Should a fistula first policy be revisited in elderly haemodialysis patients?

Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

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