1989
DOI: 10.1001/archderm.125.9.1218
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The role of liver biopsies in psoriatic patients receiving long-term methotrexate treatment. Improvement in liver abnormalities after cessation of treatment

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Cited by 38 publications
(37 citation statements)
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“…Certain drugs may have toxic eects on the liver that can mimic almost any liver disease, including ®brosis and cirrhosis [18]. Several medications capable of causing gradual liver damage that may lead to cirrhosis have been reported; these include methotrexate, methyldopa, vitamin A and amiodarone [8,10,23]. The toxicity may develop over several years without any symptoms; in the case of prolonged methotrexate usage, for example, liver biopsy is recommended for early diagnosis of possible indolent cirrhosis [18,23].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Certain drugs may have toxic eects on the liver that can mimic almost any liver disease, including ®brosis and cirrhosis [18]. Several medications capable of causing gradual liver damage that may lead to cirrhosis have been reported; these include methotrexate, methyldopa, vitamin A and amiodarone [8,10,23]. The toxicity may develop over several years without any symptoms; in the case of prolonged methotrexate usage, for example, liver biopsy is recommended for early diagnosis of possible indolent cirrhosis [18,23].…”
Section: Discussionmentioning
confidence: 99%
“…Several medications capable of causing gradual liver damage that may lead to cirrhosis have been reported; these include methotrexate, methyldopa, vitamin A and amiodarone [8,10,23]. The toxicity may develop over several years without any symptoms; in the case of prolonged methotrexate usage, for example, liver biopsy is recommended for early diagnosis of possible indolent cirrhosis [18,23]. For several medications, such as methyl-testosterone, the latency period for liver injury (time from beginning of treatment to appearance of disease) may vary from days to years [5].…”
Section: Discussionmentioning
confidence: 99%
“…198,199 In obese patients, systemic methotrexate therapy is associated with a higher risk of hepatotoxicity. [200][201][202] Drug-induced weight gain is also a significant side effect of many medications commonly prescribed by dermatologists. Such weight gain can lead to patient noncompliance as well as exacerbation of comorbid conditions related to obesity.…”
Section: Obesity and Dermatologic Pharmacologymentioning
confidence: 99%
“…Bu nedenle aralıklı tedavi vermek karaciğerin ilaca bağlı toksisiteden kurtulmasına olanak tanıyacaktır. Histolojik evresi 4 olan karaciğer fibrozisinin bile 6-12 aylık bir dinlenme döneminden sonra iyileşebileceği, oluşan hasarın geri dönüşümlü olduğu düşünülmektedir 60 . Kemik iliği supresyonu gösteren çocuk olgu bildirilmemiş olmakla beraber bu durum erişkinlerde olduğu gibi her zaman karşılaşılabilecek bir risktir.…”
Section: Metotreksatunclassified