The role of lifestyle and nutrition in psoriasis: Current status of knowledge and interventions

Musumeci, Maria Letizia; Nasca, Maria Rita; Boscaglia, Simona; Micali, Giuseppe

doi:10.1111/dth.15685

Cited by 18 publications

(17 citation statements)

References 54 publications

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“…Further, a meta‐analysis of 18 RCTs involving 927 study participants in 2020 found that fish oil or omega‐3 PUFAs monotherapy had little effect on psoriasis area and severity indices; however, they could show significant adjunctive effects when combined with traditional treatments (Chen et al, 2020 ). A review suggested that eating fish rich in n‐3 PUFAs, as well as fruits and vegetables, are beneficial for people with psoriasis (Musumeci et al, 2022 ). Some researchers have pointed out that the roles of n‐3 and n‐6 PUFAs in most common skin diseases are opposite and uncertain, but they are not simply black and white.…”

Section: Discussionmentioning

confidence: 99%

The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

Lei

Chen

Cheng

et al. 2023

Food Science & Nutrition

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Unsaturated fatty acids have been reported to be associated with the risk of psoriasis. However, the causal relationship between them remains unclear This study aimed to explore the causal relationship between unsaturated FAs and psoriasis. Firstly, we obtained genome‐wide association study (GWAS) data for psoriasis from the FINNGEN database (number of cases = 4510, number of controls = 212,242) and different FA levels (number of samples = 114,999) from the IEU OpenGWAS Project. Secondly, the genetic correlation coefficient was calculated using linkage disequilibrium fractional regression. Thirdly, a two‐sample Mendelian randomization (MR) analysis was performed using independent instrumental variables (p < 5 × 10−8) to determine the direction of randomization. Finally, expression quantitative trait loci (eQTL)‐related analyses of common single nucleotide polymorphisms (SNPs) were carried out to explore the potential molecular mechanisms of unsaturated FAs affecting psoriasis. We found that an increase in the ratio of monounsaturated fatty acids (MUFAs) to total fatty acids could increase the risk of psoriasis (inverse‐variance weighted [IVW], adjusted odds ratio [OR] = 1.175; adjusted 95% confidence interval [CI] = 1.045–1.321; adjusted p = .007). However, an increase in the ratio of polyunsaturated fatty acids (PUFAa) to total fatty acids could decrease the risk of psoriasis (IVW, adjusted OR = 0.754; adjusted 95% CI = 0.631–0.901; adjusted p = .002). Moreover, an increase in the ratio of PUFAs to MUFAs could decrease the risk of psoriasis (IVW, adjusted OR = 0.823; adjusted 95% CI = 0.715–0.948; adjusted p = .007). The heterogeneity of data was eliminated, and pleiotropy was not detected. There was no statistical difference in the MR analysis of other fatty acids indices with psoriasis. Further, no statistically significant evidence was found to verify a causal relationship between psoriasis and fatty acid levels in reverse MR. Functional enrichment analysis showed that these eQTL related to common SNPs were mainly involved in organic ion transport, choline metabolism, and the expression of key metabolic factors mediated by PKA, ChREBP, and PP2A. Our study indicated that the ratio of MUFAs to total fatty acids had a positive causal effect on psoriasis, while the ratio of PUFAs to total fatty acids and the ratio of PUFAs to MUFAs had a negative causal effect on psoriasis. Moreover, PKA‐, PP2A‐, and ChREBP‐mediated activation of metabolic factors may play an important role in this process.

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Section: Discussionmentioning

confidence: 99%

The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

Lei

Chen

Cheng

et al. 2023

Food Science & Nutrition

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“…Dietary intake is related to psoriasis severity whereby a diet high in saturated fat and red and simple sugar is associated with inflammation. Meanwhile, vitamin D, vitamin B12, vitamin A and selenium play an important role in improving severity [ 6 , 103 , 104 ]. Therefore, dietary assessment is pertinent to determine the nutritional status of patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with psoriasis who are overweight and obese are more likely to develop MetS. Therefore, early dietary intervention is needed to improve the nutritional status, reduce the risk of metabolic disorders and improve the effectiveness of treatments [ 103 , 104 , 109 , 110 ]. Dietary recommendations are often individualised based on the patients’ comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Screening and Nutritional Status of Patients with Psoriasis: A Scoping Review

et al. 2023

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Background: Patients with plaque psoriasis have an increased risk of metabolic syndrome. However, no studies have assessed the nutritional status or screening methods of this population. Aims: This review aimed to identify and summarise metabolic syndrome screening criteria and the tools/methods used in nutrition assessment in patients with plaque psoriasis. Data synthesis: PubMed, Web of Science, Ovid and Scopus were searched from inception to March 2023, following the Arkensey and O’Malley framework, to identify articles that report nutritional assessment methods/tools and metabolic screening criteria. Twenty-one studies were identified. Overall, these studies used four different screening criteria to define metabolic syndrome. Patients with psoriasis had a high prevalence of metabolic syndrome and had a poor nutritional status compared to controls. However, only anthropometric measures such as weight, height and waist circumference were employed to determine the nutritional status. Only two studies assessed the vitamin D status. Conclusions: Patients with psoriasis have a poor nutritional status, and they are at risk of nutrient deficiencies. However, these health aspects are not routinely assessed and may increase the risk of malnutrition among these patients. Therefore, additional assessments, such as body composition and dietary assessment, are needed to determine the nutritional status to provide a suitable intervention.

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“…By contrast, the premise of a vegetarian diet is to eschew meat and meat products in favour of large amounts of groats, cereals, legumes, vegetables, fruits, nuts, and mushrooms, reduces the supply of arachidonic acid and its derivatives, prostaglandins and leukotriene B4, which have pro-inflammatory effects [66]. A vegetarian diet benefits weight maintenance, as it results in a lower intake of saturated fatty acids and cholesterol, which is important for patients with psoriasis.…”

Section: Vegetarian Dietmentioning

confidence: 99%

A crossroads between dietary habits, alcohol consumption, and smoking in the clinical course of psoriasis: a narrative review

Michalski,

Palazzo-Michalska,

Buda

et al. 2023

pdia

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Psoriasis is a chronic autoimmune disease that affects 1-3% of the population. The pathomechanism of psoriasis development is complex, but genetic (non-modifiable) factors play a key role. However, the importance of environmental factors and lifestyle choices, such as the diet, alcohol consumption, and smoking, is increasing. The objective of this review was to analyse the influence of dietary habits, alcohol consumption, and smoking on the clinical course of psoriasis. Stress, a poor diet, alcohol abuse, and smoking can trigger psoriasis or cause its exacerbation. Therefore, in addition to the correct selection of therapy, it is extremely important to educate patients about the impact of these factors on the onset and progression of psoriasis. This literature review confirms that a holistic and multidisciplinary approach is required for patients with psoriasis, further emphasizing Hippocrates' thesis, "Let food be thy medicine, and medicine be thy food".

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The role of lifestyle and nutrition in psoriasis: Current status of knowledge and interventions

Cited by 18 publications

References 54 publications

The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

Metabolic Syndrome Screening and Nutritional Status of Patients with Psoriasis: A Scoping Review

A crossroads between dietary habits, alcohol consumption, and smoking in the clinical course of psoriasis: a narrative review

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