The role of KIR positive NK cells in diseases and its importance in clinical intervention

Asl, Khadijeh Dizaji; Velaei, Kobra; Rafat, Ali; Nasrabadi, Hamid Tayefi; Movassaghpour, Ali Akbar; Mahdavi, Majid; Charoudeh, Hojjatollah Nozad

doi:10.1016/j.intimp.2020.107361

Cited by 20 publications

(22 citation statements)

References 158 publications

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“…Pharmacologic modulation of this effect is essential in order to achieve that goal [98]. The therapy has been primarily based upon indirect knowledge from animal models and in the analysis performed in patients with recurrent abortions due to nongenetic or pathogenic events [98][99][100]. However, different medical conditions in which therapy may substantially affect pregnancy outcomes may be related to NK function.…”

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

“…One crucial analysis is based on the fact that peripheral blood NK cells may not be appropriate to determine treatment effect [98][99][100]. Variations, upon treatment, on circulating cell quantities, and a decrease in cytotoxic responses may be due either to changes in the activation markers or changes in subpopulations based upon cell maturation.…”

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

“…NK cells in recurrent spontaneous abortion have been several pharmacological therapies used [98][99][100]. Some therapies are based on a general anti-inflammatory rationale, screening peripheral blood NK cells subpopulations and cytotoxic activity [98][99][100]. However, treatment efficiency depends on pregnancy success and complete pregnancy with alive newborns [99,100].…”

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

“…Some therapies are based on a general anti-inflammatory rationale, screening peripheral blood NK cells subpopulations and cytotoxic activity [98][99][100]. However, treatment efficiency depends on pregnancy success and complete pregnancy with alive newborns [99,100]. In some cases, therapeutic modulation has been shown to increase the number of genetic malformations and the possibility of preeclampsia, eclampsia, or HELLP syndrome [98][99][100].…”

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

“…However, treatment efficiency depends on pregnancy success and complete pregnancy with alive newborns [99,100]. In some cases, therapeutic modulation has been shown to increase the number of genetic malformations and the possibility of preeclampsia, eclampsia, or HELLP syndrome [98][99][100]. Hence, the modulation of tissue-resident NK cells and conventional NK cells may alter the local biological response.…”

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

See 4 more Smart Citations

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

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NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology.

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Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

Section: Pharmacological Modulation Of Nk Cellsmentioning

confidence: 99%

See 3 more Smart Citations

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

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Telomerase‐based therapies in haematological malignancies

Rafat

Asl

Mazloumi

et al. 2022

Cell Biochemistry & Function

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Telomeres are specialized genetic structures present at the end of all eukaryotic linear chromosomes. They progressively get shortened after each cell division due to end replication problems. Telomere shortening (TS) and chromosomal instability cause apoptosis and massive cell death. Following oncogene activation and inactivation of tumour suppressor genes, cells acquire mechanisms such as telomerase expression and alternative lengthening of telomeres to maintain telomere length (TL) and prevent initiation of cellular senescence or apoptosis. Significant TS, telomerase activation and alteration in expression of telomere‐associated proteins are frequent features of different haematological malignancies that reflect on the progression, response to therapy and recurrence of these diseases. Telomerase is a ribonucleoprotein enzyme that has a pivotal role in maintaining the TL. However, telomerase activity in most somatic cells is insufficient to prevent TS. In 85‐90% of tumour cells, the critically short telomeric length is maintained by telomerase activation. Thus, overexpression of telomerase in most tumour cells is a potential target for cancer therapy. In this review, alteration of telomeres, telomerase and telomere‐associated proteins in different haematological malignancies and related telomerase‐based therapies are discussed.

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NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients

Asl

Mazloumi

Majidi

et al. 2022

Cell Biochemistry & Function

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SARS‐CoV‐2 first raised from Wuhan City, Hubei Province in November 2019. The respiratory disorder, cough, weakness, fever are the main clinical symptoms of coronavirus disease 2019 (COVID‐19) patients. Natural Killer (NK) cells as a first defense barrier of innate immune system have an essential role in early defense against pulmonary virus. They kill the infected cells by inducing apoptosis or the degranulation of perforin and granzymes. Collectively, NK cells function are coordinated by the transmitted signals from activating and inhibitory receptors. It is clear that the cytotoxic function of NK cells is disrupted in COVID‐19 patients due to the dysregulation of activating and inhibitory receptors. Therefore, better understanding of the activating and inhibitory receptors mechanism could facilitate the treatment strategy in clinic. To improve the efficacy of immunotherapy in COVID‐19 patients, the functional detail of NK cell and manipulation of their key checkpoints are gathered in current review.

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The role of KIR positive NK cells in diseases and its importance in clinical intervention

Cited by 20 publications

References 158 publications

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Telomerase‐based therapies in haematological malignancies

NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients

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