The Role of Intravoxel Incoherent Motion MRI in Predicting Early Treatment Response to Chemoradiation for Metastatic Lymph Nodes in Nasopharyngeal Carcinoma

Abstract

The present study indicated that the initial f value may be more accurate than the initial D*, D, and ADC in the early prediction of treatment response to chemoradiotherapy for metastatic lymph nodes in patients with NPC.

Monitoring the Early Antiproliferative Effect of the Analgesic–Antitumor Peptide, BmK AGAP on Breast Cancer Using Intravoxel Incoherent Motion With a Reduced Distribution of Four b-Values

“…Common MRI ways of assessing the response to therapy are DCE-MRI and DWI. Recently, many studies focused on the use of the IVIM bi-exponential model for the same purpose and labeled the non-invasive method to be more accurate than DWI by giving separate diffusion- and perfusion-related parameters (Granata et al, 2015; Lu et al, 2016; Shirota et al, 2016; Lee et al, 2017; Yang et al, 2017). The areas of necrosis might increase in the diffusion-weighted coefficient and perhaps mislead the assessment of the response of a tumor to therapy (Bains et al, 2012).…”

Diffusion-weighted MRI for predicting treatment response in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

“…After screening the titles and abstracts, 22 articles were considered potentially eligible after excluding 108 articles for the following reasons: non-English articles (n = 22), case reports (n = 9), not in the field of interest (n = 56), non-original articles (i.e., reviews, letters, editorials, conference abstracts) (n = 18), and non-human studies (n = 3). After full-text review, nine articles were further excluded because they were not in the field of interest (n = 1) 28 , had overlapping study populations (n = 2) 10 , 29 , had insufficient information for the reconstruction of 2 × 2 tables (n = 1) 30 , insufficient detail of pretreatment ADC (n = 3) 31 – 33 , or region of interest was on lymph nodes only (n = 2) 34 , 35 . Thirteen original studies were included for qualitative synthesis 5 , 6 , 8 , 9 , 11 – 19 .…”

Comparison of the pre-treatment functional MRI metrics’ efficacy in predicting Locoregionally advanced nasopharyngeal carcinoma response to induction chemotherapy

“…These discoveries corroborated with the ideas of Yu, who suggested that non-residual group also had lower ADC-pre than the residual group [ 20 ]. The role of ADC values in predicting treatment response to chemoradiotherapy was also proven in metastatic lymph nodes in patients with NPC [ 8 ]. King et al found that the primary tumor showed significantly lower increase in percentage change of mean ADC for local failure than for local control [ 34 ].…”

“…The advances in imaging modalities have led to improving the ability of diagnosing NPC [ 7 ], predicting and assessing tumor responding to treatment [ 8 – 12 ]. The apparent diffusion coefficient (ADC) which represents cellularity and interstitial water mobility is calculated by diffusion weighted imaging (DWI) using mono-exponential model reflecting Gaussian diffusion.…”

“…Intravoxel incoherent motion (IVIM) diffusion weighted model, using multiple b values and bi-exponential fitting equation, can quantify and discriminate pure water molecular diffusion and microcirculatory perfusion of the tissue [ 17 , 18 ]. Several studies have investigated potential value of the parameters derived from IVIM in assessing and predicting its radiotherapy or chemotherapy response [ 8 , 10 , 19 – 21 ]. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), a functional imaging modality, was identified as a valuable tool of reflecting tumor angiogenesis density, vascular permeability and tumor neo-angiogenesis blood flow [ 22 , 23 ].…”