The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma

Berti, Fernanda Costa Brandão; Pereira, Ana Paula Lombardi; Cebinelli, Guilherme Cesar Martelossi; Trugilo, Kleber Paiva; Oliveira, Karen Brajão de

doi:10.1016/j.cytogfr.2017.03.002

Cited by 63 publications

(50 citation statements)

References 108 publications

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“…A negative correlation between IL-10 and the pro-inflammatory cytokine IFN-γ in HPV (Figure 3 B and C) suggests the stimulation of strong anti-inflammatory response. The higher activity of IL-10 during HPV infection is congruent with studies suggesting a role for IL-10 in immune evasion through immunosuppressive state (31) . EBOV activated both anti-and pro-inflammatory cytokines at high levels.…”

Section: Discussionsupporting

confidence: 83%

“…As we discussed previously, HPV exerts a robust anti-inflammatory response mediated by IL-10 and TGF-β, and creates an immunosuppressive environment. HPV infects primitive basal keratinocytes (38) that produce IL-10, which further facilitates the infection process via a positive feedback loop between IL-10 and HPV transcription (31) . At the same time, HPV downregulates the expression of IFNs (39) .…”

Section: Discussionmentioning

confidence: 99%

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Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Puniya

Moore

Mohammed

et al. 2020

Preprint

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The human immune system, which protects against pathogens and diseases, is a complex network of cells and molecules. The effects of complex dynamical interactions of pathogens and immune cells on the immune response can be studied using computational models. However, a model of the entire immune system is still lacking. Here, we developed a comprehensive computational model that integrates innate and adaptive immune cells, cytokines, immunoglobulins, and nine common pathogens from different classes of virus, bacteria, parasites, and fungi. This model was used to investigate the dynamics of the immune system under two scenarios: (1) single infection with pathogens, and (2) various medically relevant pathogen coinfections. In coinfections, we found that the order of infecting pathogens has a significant impact on the dynamics of cytokines and immunoglobulins. Thus, our model provides a tool to simulate immune responses under different dosage of pathogens and their combinations, which can be further extended and used as a tool for drug discovery and immunotherapy. Furthermore, the model provides a comprehensive and simulatable blueprint of the human immune system as a result of the synthesis of the vast knowledge about the network-like interactions of various components of the system.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Puniya

Moore

Mohammed

et al. 2020

Preprint

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“…It is found to specifically trigger cancer progression and tumor maintenance. 7 Interleukin-6 (IL-6) is a major component of almost all TME. Recent study has shed light that IL-6 not only activates inflammation but also controls a number of pro-cancer activities like progression, malignancy and anti-death signaling pathways.…”

Section: Role Of Cytokines In Shaping Non-cellular Microenvironmentmentioning

confidence: 99%

Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics

Patel

Nilendu

Jahagirdar

et al. 2017

Cancer Biology & Therapy

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The microenvironment in which cancer resides plays an important role in regulating cancer survival, progression, malignancy and drug resistance. Tumor microenvironment (TME) consists of heterogeneous number and types of cellular and non-cellular components that vary in relation to tumor phenotype and genotype. In recent, non-cellular secreted components of microenvironmental heterogeneity have been suggested to contain various growth factors, cytokines, RNA, DNA, metabolites, structural matrix and matricellular proteins. These non-cellular components have been indicated to orchestrate numerous ways to support cancer survival and progression by providing metabolites, energy, growth signals, evading immune surveillance, drug resistance environment, metastatic and angiogenesis cues. Thus, switching action from pro-cancer to anti-cancer activities of these secreted components of TME has been considered as a new avenue in cancer therapeutics and drug resistance. In this report, we summarize the recent pre-clinical and clinical evidences to emphasize the importance of non-cellular components of TME in achieving precision therapeutics and biomarker study.

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“…Although HPV exerts a vital influence on cervical carcinogenesis, other factors influence the development of a squamous intraepithelial lesion (SIL) that may or not progress to cervical cancer. In the cervical microenvironment, several immune components play important roles in establishing HPV infection as well as on SIL regression or progression to cervical cancer (Berti, Pereira, Cebinelli, Trugilo, & Oliveira, ). In this context immune mediators, such as chemokines and their receptors (small chemotactic cytokines that direct the migration of leucocytes during inflammation) are important since they are involved in the regulation of leucocyte trafficking in many essential biological processes, including inflammation, which is thought to facilitate carcinogenesis by providing a microenvironment that is ideal for tumour cell development and growth (Okuyama, Santos, Trugilo, & Oliveira, ; Rossi & Zlotnik, ).…”

Section: Introductionmentioning

confidence: 99%

CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions

Mangieri

Sena

Cezar-dos-Santos

et al. 2019

Int J Immunogenetics

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Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell‐mediated immunity within 1–2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context, we highlight the CC chemokine receptor 5 (CCR5) which is involved in leucocytes chemotaxis to sites of inflammation, controlling the immune response. The CCR5 rs333 genotyping of 164 HPV infected women and 185 non‐infected women was performed using polymerase chain reaction (PCR). HPV infection was more frequent among women under 34 years old (p < 0.001), single (p = 0.001), that received 1 minimum wage or less (p = 0.002), tobacco smokers (p = 0.007), who had the first sexual intercourse before 17 years old (p = 0.038) and that had 4 or more sexual partners during lifetime (p = 0.001). No significant difference regarding genotypes and alleles distribution according to HPV infection was observed. CCR5/CCR5 genotype was observed in 94.1% of HPV non‐infected women and in 89% of infected ones, CCR5/Δ32 in 5.9% of HPV infected and in 10.4% of non‐infected women, and Δ32/Δ32 was observed in only one (0.6%) infected patient. CCR5 genotypes were also not associated with cervical lesions development among HPV infected women (p = 0.167). Since CCR5 may control the antitumour immune response and cervical lesions and the studied rs333 polymorphism is not very frequent, other studies are necessary, in order to establish CCR5 role on HPV infection and squamous intraepithelial lesions development.

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The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma

Cited by 63 publications

References 108 publications

Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Immune Digital Twin Blueprint: A Comprehensive Mechanistic Model of the Human Immune System

Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics

CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions

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