2013
DOI: 10.18632/aging.100531
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Abstract: Abstract:The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation in Age-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improvin… Show more

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Cited by 180 publications
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“…ET-1 has also been associated with age-associated diseases [44], a relationship that might be due to activation of pro-inflammatory pathways [45]. Although our participants' ages ranged from 26 to 65 years, we did not see find any relationship between ET-1 and age.…”
Section: Discussioncontrasting
confidence: 60%
“…ET-1 has also been associated with age-associated diseases [44], a relationship that might be due to activation of pro-inflammatory pathways [45]. Although our participants' ages ranged from 26 to 65 years, we did not see find any relationship between ET-1 and age.…”
Section: Discussioncontrasting
confidence: 60%
“…It is not known whether increased inflammation up-regulates tissue senescence pathway or whether accelerated cell senescence signaling causes tissue inflammation; nonetheless, they seem to be always accompanied by each other. Most of the time, increased cell senescent signaling is also associated with increased tissue inflammation (41). It has been known that cellular senescence is a stable form of cell cycle arrest that may limit the proliferative potential of a cell and promotes aging (42).…”
Section: Discussionmentioning
confidence: 99%
“…Among other activities early on was a workshop focused on inflammation and age-related diseases, held at the NIH Campus in September 2012 (Howcroft et al 2013). This in turn led to the publication of a funding opportunity (a program announcement) joined by 10 of the GSIG member Institutes.…”
Section: Early Activitiesmentioning
confidence: 99%