The Role of Immunohistochemistry in Diagnosis of Lung Cancer With Correlation of Serum Tumour Marker Carcinoembryonic Antigen

Abstract

BACKGROUND Immunohistochemistry is a less challenging, widely available technique which provides clinically meaningful results quickly and allows for cellular localization of proteins in the context of tumour structure. Lung cancer is the leading cause of cancer-related deaths worldwide, regardless of gender. In an era of precision medicine, pathologists are required to classify lung cancer into specific subtypes and assess biomarkers relevant to molecular targeted therapies but overlapping of microscopic features of different types of tumours sometimes makes diagnosis difficult for pathologists. The objectives of this study were-1. to accurately diagnose small and non-small cell lung carcinoma for targeted therapy. 2. to differentiate between adenocarcinoma lung and malignant mesothelioma. 3. to determine primary site of origin in patients who present with metastatic disease. 4. to correlate serum CEA level and lung carcinoma.