The role of IL-6 in dopamine dysregulation underlying anhedonia phenotype in rats
Roger B Varela,
Heather Macpherson,
Tristan Houghton
et al.
Abstract:AimsTo investigate the role of peripheral metabolic change and chronic low-grade inflammation on striatal dopamine dynamics and anhedonia-like behaviour induced by hypothalamic–pituitary–adrenal (HPA) axis disruption.MethodsWistar rats were trained in a progressive-ratio/concurrent effort-related choice paradigm to assess effort-related decision making. After reaching a stable baseline, animals received daily injections of adrenocorticotrophic hormone (ACTH) or saline for 24 days. On the 23rdand 24thday, anima… Show more
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