Arch Dermatol
 2007
DOI: 10.1001/archderm.143.2.249
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The Role of IgE Anti–Basement Membrane Zone Autoantibodies in Bullous Pemphigoid

David T. Woodley
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Cited by 17 publications

(6 citation statements)
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“…Regarding our observed shaggy pattern IgE anti-BMZ autoantibodies, we could not find any previous report of a vasculitic process demonstrating this specific pattern. IgE anti-BMZ antibodies may present in bullous pemphigoid in a linear pattern, but would not be expected to demonstrate the overall pattern of IgE in a lupus band [9]. The clinical and pathological significance of our finding remains uncertain.…”
Section: Discussionmentioning
confidence: 66%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Regarding our observed shaggy pattern IgE anti-BMZ autoantibodies, we could not find any previous report of a vasculitic process demonstrating this specific pattern. IgE anti-BMZ antibodies may present in bullous pemphigoid in a linear pattern, but would not be expected to demonstrate the overall pattern of IgE in a lupus band [9]. The clinical and pathological significance of our finding remains uncertain.…”
Section: Discussionmentioning
confidence: 66%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In fact, it is thought that IgE autoantibodies directed against the ectodomain of BP180 are first bound to FceRI on mast cells and eosinophils. This binding subsequently promotes degranulation and initiates an inflammatory reaction resulting in further tissue damage and blister formation (44,97,111,(131)(132)(133). In addition, binding of specific IgE autoantibodies to the ectodomain of BP180 on basal keratinocytes also triggers internalization of BP180 (see above) and thereby contributes to cell-substrate disadhesion (44,119,134).…”
Section: Lessons From the Bedside And Targeted Therapiesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Tatsächlich wird angenommen, dass IgE-Autoantikörper, die gegen die Ektodomäne von BP180 gerichtet sind, zuerst an FcERI auf Mastzellen und Eosinophilen gebunden werden. Diese Bindung fördert anschließend die Degranulation und löst eine Entzündungsreaktion aus, die zu weiterer Gewebeschädigung und Blasenbildung führt [44, 97, 111, 131-133]. Darüber hinaus löst die Bindung spezifischer IgE-Autoantikörper an die Ektodomäne von BP180 auf basalen Keratinozyten auch die Internalisierung von BP180 aus (siehe oben) und trägt dadurch zur Zell-Substrat-Disadhäsion bei [44, 119, 134].…”
Section: Lektionen Vom Krankenbett Und Gezielte Therapienunclassified
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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