The role of human papillomaviruses in carcinogenesis

Ghittoni, Raffaella; Accardi, Rosita; Chiocca, Susanna; Tommasino, Massimo

doi:10.3332/ecancer.2015.526

Cited by 143 publications

(156 citation statements)

References 60 publications

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“…As a result even after the vaccination, the tendency for patients to be infected with other strains still exists. Hence, both bivalent and quadrivalent do not cover 20-30% of HPV-associated cancers (17) . …”

Section: Vaccines Against Other Hpv Typesmentioning

confidence: 99%

“…The support of government funding to make HPV vaccines as national health program is crucial, although, in reality, it is a difficult decision (31) . Cost is one of the major barriers in reducing cervical cancer, in the USA a survey was done in 2008 found that only 12% among female adolescents aged [11][12][13][14][15][16][17] To who had no health insurance received HPV vaccination (32) . This shows that public is not willing to pay to get vaccinated.…”

Section: Cost and Affordabilitymentioning

confidence: 99%

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Role of HPV Vaccination in Fighting Cervical Cancer

Po¹,

Aili²,

Waheed³

2017

IAM

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Type 16 and Type 18 Human Papilloma Virus are highly associated with cervical cancer. Vaccination against these two types has been proved to be the most successful method to control this sexually transmitted disease. The vaccines have also been proved to be safe, but unfortunately, the incidence is still rising. In this review, we consider the accumulated evidence that HPV vaccines are already reducing burned in cervical cancer and preventing HPV infection, summarize the efficacy from different angles from scientific, social and economy while discussing the new generation nine-valent HPV vaccines.

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Section: Vaccines Against Other Hpv Typesmentioning

confidence: 99%

Section: Cost and Affordabilitymentioning

confidence: 99%

Role of HPV Vaccination in Fighting Cervical Cancer

Po¹,

Aili²,

Waheed³

2017

IAM

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“…Although this virus exists in over 170 variants, and several of them cause cancer, there are none to very few sequences of some of the important variants available in the NIH GenBank database. Although available vaccines against the primary types of this dsDNA (double-stranded DNA) virus have proved very effective, they leave out 20-30% of the cases [30] and continue to be very expensive, often beyond the capacity of affordability of a vast swathe of human population. It is possible that adequate data are available but are being held back for unexplained reasons, but lack of such data hinders intensive analyses and prolongs the sufferings of a large section of humanity.…”

Section: Rational Design Of Peptide Vaccines Against the Zika Virus Tmentioning

confidence: 99%

Rational design of peptide vaccines against the Zika virus through sequence descriptors: Techniques and Problems

Nandy¹,

Basak²

2016

IJVR

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The sudden emergence of an epidemic of Zika virus infections in South America has raised concerns of its virulence and transmission potential, especially in view of mass gatherings at carnivals, Olympic Games, Hajj and others within this year [1]; the as yet unproven link between the Zika epidemic and heightened cases of microcephaly among newborns for which the World Health Organization (WHO) have declared on February 1, 2016 the suspected association of the virus to cases of microcephaly and Guillain-Barre disease to be Public Health Emergency of International Concern [2] has added to the anxieties. The main vector of the Zika virus is the Aedes aegypti mosquito prevalent in tropical countries but whose range is increasing with the effects of global warming, recognized as causing shifts in distribution of vector-borne diseases [3]; spread of the virus through mass gatherings to other countries becomes an additional worrying possibility. The issues here are of serious concern since the Aedes aegypti mosquito is also a primary carrier of the dengue virus and Brazil has not had much success in controlling that [4]. Coming soon after the scare of Ebola virus, and with the background of the 2009 H1N1 pandemic, the MERS and SARS epidemics, the near-pandemic of H5N1 bird flu and fatalities associated with the H7N9, the Zika virus epidemic has focused questions on containment and mitigation of viral activity and further zoonotic issues that may arise.Such recurrent viral incidences and emergence necessitate a combinatorial analysis and perspective on confronting and containing the menace. Given the nature and diversity of infective viruses, it would seem difficult for such a task to be contemplated by a priori experimental means, whereas theories behind such phenomena are yet to be devised. In such a circumstance, phenomenological approaches as offered by numerical characterizations of bio-molecular sequences arising from their graphical representations hold some promise of approaching the issue. Numerical characterizations of DNA, RNA and protein sequences provide descriptors that are characteristic of each sequence, albeit depending upon the particular methodology used [5]. Developing upon initial work on DNA sequences, these descriptors have been used to characterize genes to genomes [5] and proteins [6] to proteomes [7], and have seen applications in many areas. While Nandy [8-10], Nandy and Nandy [11] and Larionov et al [12] have used 2D graphical systems to determine DNA systematics, Liao et al [13,14] used the novel techniques for alignment-free phylogeny to determine sequence ancestry, Wiesner and Wiesnerova [15] found the new methodology giving better insights into germ-plasm identifiers, Gonzalez-Diaz and his group presented several papers using the concept for alignment-free prediction of polygalacturonases [16], alternative "in silico" technique for chemical research in toxicology [17] and predicting antimicrobial drugs and targets [18], Nandy et al [19] were able to model influenza hemagglutinin and neura...

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“…High-risk HPV types, such as HPV 16, 18, 31, 33, and 35, are mostly associated with cancer (5). HPV 16 and 18 are the most prevalent types reported worldwide, contributing to approximately 70% of cervical cancers, while other high-risk HPV genotypes are associated with more than 20% of cervical cancers globally (3,6).…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Abedini

Karimi

Shamsy

et al. 2016

Arch Pediatr Infect Dis

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Background: Human papillomavirus (HPV) is a DNA virus that establishes productive infections only in keratinocytes of the skin or mucous membranes. Objectives: This study aimed to determine the frequency of two high-risk genotypes of HPV among married and unmarried Iranian women. Materials and Methods:This cross-sectional population-based study consisted of two groups of women: non-married girls referred for premarital counseling, and married women referred for pregnancy diagnosis. Blood samples were evaluated serologically with the ELISA method for HPV types 16 and 18. Results: A total of 177 women (89 single and 88 married) were tested for HPV strains. The frequency of HPV type 16 in single women was significantly higher than in married women (66.3% vs. 40.9%, P < 0.001). The relative frequency of HPV type 18 was also significantly higher in single women than in married women (62.9% vs. 47.7%, P < 0.001). Moreover, HPV type 16 and 18 positivity was significantly associated with higher education levels in single women compared to married women (P < 0.001). Classification of HPV-infected women according to age revealed that the frequency of HPV type 16 was significantly higher in single women aged 25 -35 years compared to married women (P < 0.05). Conclusions:The results showed remarkable rates of high-risk HPV types (16 and 18) in the studied population, which can be a serious alert for public health. This result highlights the potential impact of prophylactic vaccines for future protection against high-risk HPV types in Iranian women.

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The role of human papillomaviruses in carcinogenesis

Cited by 143 publications

References 60 publications

Role of HPV Vaccination in Fighting Cervical Cancer

Role of HPV Vaccination in Fighting Cervical Cancer

Rational design of peptide vaccines against the Zika virus through sequence descriptors: Techniques and Problems

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

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