The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

Kourtidou, Christodoula; Τζιόμαλος, Κωνσταντίνος

doi:10.3390/ijms24066007

Cited by 10 publications

(6 citation statements)

References 118 publications

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“…Histone acetylation has also been linked to diabetic complications, such as diabetic retinopathy [138] (Figure 1). Recent evidence indicates that histone modification appears to initiate oxidative stress, inflammation, and fibrosis in the diabetic kidney [139]. Research conducted on diabetic mice showed that early glomerulosclerosis was linked to diminished H3K9 and H3K23 histone acetylation [140].…”

Section: Discussionmentioning

confidence: 99%

“…Since gluconeogenesis is a primary factor in hepatic glucose production in people with diabetes and insulin impacts gluconeogenesis through transcription, identifying the insulin signaling pathways that affect gluconeogenic gene transcription and gluconeogenesis can contribute to comprehending PTDM pathophysiology (Figure 1). inflammation, and fibrosis in the diabetic kidney [139]. Research conducted on diabetic mice showed that early glomerulosclerosis was linked to diminished H3K9 and H3K23 histone acetylation [140].…”

Section: Pathways Associated With Ptdmmentioning

confidence: 99%

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Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus

Abdelrahman,

Maxwell,

McKnight

2024

Genes

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Post-transplant diabetes mellitus (PTDM) is a common complication of solid organ transplantation. PTDM prevalence varies due to different diabetes definitions. Consensus guidelines for the diagnosis of PTDM have been published based on random blood glucose levels, glycated hemoglobin (HbA1c), and oral glucose tolerance test (OGTT). The task of diagnosing PTDM continues to pose challenges, given the potential for diabetes to manifest at different time points after transplantation, thus demanding constant clinical vigilance and repeated testing. Interpreting HbA1c levels can be challenging after renal transplantation. Pre-transplant risk factors for PTDM include obesity, sedentary lifestyle, family history of diabetes, ethnicity (e.g., African-Caribbean or South Asian ancestry), and genetic risk factors. Risk factors for PTDM include immunosuppressive drugs, weight gain, hepatitis C, and cytomegalovirus infection. There is also emerging evidence that genetic and epigenetic variation in the organ transplant recipient may influence the risk of developing PTDM. This review outlines many known risk factors for PTDM and details some of the pathways, genetic variants, and epigenetic features associated with PTDM. Improved understanding of established and emerging risk factors may help identify people at risk of developing PTDM and may reduce the risk of developing PTDM or improve the management of this complication of organ transplantation.

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Section: Discussionmentioning

confidence: 99%

Section: Pathways Associated With Ptdmmentioning

confidence: 99%

Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus

Abdelrahman,

Maxwell,

McKnight

2024

Genes

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“…The nature of these modifications can be either activating, repressive, or inheritable. In individuals with T2D, if the balance of histone modifications is altered, it leads to changes in gene expressions that can further contribute to the advancement of the disease [ 41 ]. One of the main histone modifications associated with T2D is histone acetylation, which is an activating modification linked to increased gene expression.…”

Section: Factors Leading To Development Of T2dmentioning

confidence: 99%

Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review

Singh,

Kriti,

K.S.

et al. 2024

Metabolism Open

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“…In the context of DKD, histone modifications are crucial in regulating gene expression patterns that contribute to the progression of the disease [306,307]. For instance, studies have shown that certain histone modifications, such as acetylation and methylation, are associated with the dysregulation of genes involved in inflammation [308][309][310][311], fibrosis [312,313], and oxidative stress responses [314,315] in DKD.…”

Section: Genetics and Epigenetics Of Dkdmentioning

confidence: 99%

Pathomechanisms of Diabetic Kidney Disease

Sinha,

Nicholas

2023

JCM

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The worldwide occurrence of diabetic kidney disease (DKD) is swiftly rising, primarily attributed to the growing population of individuals affected by type 2 diabetes. This surge has been transformed into a substantial global concern, placing additional strain on healthcare systems already grappling with significant demands. The pathogenesis of DKD is intricate, originating with hyperglycemia, which triggers various mechanisms and pathways: metabolic, hemodynamic, inflammatory, and fibrotic which ultimately lead to renal damage. Within each pathway, several mediators contribute to the development of renal structural and functional changes. Some of these mediators, such as inflammatory cytokines, reactive oxygen species, and transforming growth factor β are shared among the different pathways, leading to significant overlap and interaction between them. While current treatment options for DKD have shown advancement over previous strategies, their effectiveness remains somewhat constrained as patients still experience residual risk of disease progression. Therefore, a comprehensive grasp of the molecular mechanisms underlying the onset and progression of DKD is imperative for the continued creation of novel and groundbreaking therapies for this condition. In this review, we discuss the current achievements in fundamental research, with a particular emphasis on individual factors and recent developments in DKD treatment.

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The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

Cited by 10 publications

References 118 publications

Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus

Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus

Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review

Pathomechanisms of Diabetic Kidney Disease

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