Magdalena L. Circu, Sarah Stringer, Carol Ann Rhoads, Mary Pat Moyer, Tak Yee Aw
AbstractStaurosporine (STP) was shown to induce cell apoptosis through formation of reactive oxygen species, but a role for cellular redox has not been defined. In this study, we report that STP (2μM) caused apoptosis (24±3% at 24h) of human colon adenocarcinoma epithelial cell line HT29 that was preceded by significant GSH and GSSG efflux (6h), but independent of changes in cellular GSH/ GSSG redox status. The blockade of GSH efflux by γ-glutamyl glutamate (γ-GG) or ophthalmic acid was associated with apopto…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute of Drug Abuse of the National Institutes of Health.