JAMA
 2001
DOI: 10.1001/jama.286.13.1635-jms1003-3-1
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

The Role of Genomics in Public Health and Disease Prevention

Karen Steinberg1,
Marta Gwinn2,
Muin J. Khoury3
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
12
0
0
0

Citation Types

0
1
0
2

Year Published

2002
2002
2011
2011

Publication Types

Select...
11
1

Relationship

0
12

Authors

Journals

citations

Cited by 12 publications

(3 citation statements)
references

References 4 publications

0
1
0
2
Order By: Relevance
“…Os principais exemplos da medicina personalizada referem-se aos testes genéticos que designam escolhas terapêuticas individuais (10) . Os testes genéticos já validados devem ser submetidos a estudos de sensibilidade, especificidade e valores preditivos em relação aos genótipos (validação analítica) e resultados assistenciais (validação clínica) (23) , assim como deve ser definido o custo-benefício de cada um desses ensaios, direcionando, principalmente para a população-alvo, implicações sociais, fenotípicas e de resultados financeiros (11) .…”
Section: Medicina Personalizada E Genética
unclassified
“…Algumas dificuldades e barreiras existem para a introdução dessa medicina na prática, como descobertas e definições que doenças de alta prevalência, como neoplasias, doenças cardíacas e diabetes, têm como base etiológica os componentes genéticos complexos e não mendelianos, dificultando a identificação dessas mutações. Variantes de múltiplos genes contribuem para uma pequena parte do risco total do paciente (23) .…”
Section: Medicina Personalizada E Genética
unclassified
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Os principais exemplos da medicina personalizada referem-se aos testes genéticos que designam escolhas terapêuticas individuais (10) . Os testes genéticos já validados devem ser submetidos a estudos de sensibilidade, especificidade e valores preditivos em relação aos genótipos (validação analítica) e resultados assistenciais (validação clínica) (23) , assim como deve ser definido o custo-benefício de cada um desses ensaios, direcionando, principalmente para a população-alvo, implicações sociais, fenotípicas e de resultados financeiros (11) .…”
Section: Medicina Personalizada E Genética
unclassified
“…Algumas dificuldades e barreiras existem para a introdução dessa medicina na prática, como descobertas e definições que doenças de alta prevalência, como neoplasias, doenças cardíacas e diabetes, têm como base etiológica os componentes genéticos complexos e não mendelianos, dificultando a identificação dessas mutações. Variantes de múltiplos genes contribuem para uma pequena parte do risco total do paciente (23) .…”
Section: Medicina Personalizada E Genética
unclassified
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…has made immense advances in deciphering diseases conditions, disease progression, prognosis and even up-to certain level cure for particular conditions. Genomics can play important role both in prevention and treatment of many diseases (Steinberg et al 2001). The advanced technologies used in genomics and related sciences can help understanding role of genes in diseases and health.…”
Section: Ayugenomis: Role In Future Of Drug Discovery
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo