The Role of FTO Gene Alleles on the Diet and Metabolic Risk Factors in the Subjects with Diabetes

Fawwad, Asher; Siddiqui, Iftikhar Ahmed; Shaheen, Fariha; Hakeem, Rubina; Waris, Nazish; Nawab, Syeda Nuzhat; Shahid, Syed Muhammad; Parker, Anna; Basit, Abdul

doi:10.25179/tjem.2017-57015

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Studies suggest that the genetic profile is likely to affect both dietary habits as well as the association between diet and metabolic syndrome markers. Therefore, it can be concluded that the diet-disease associations are more prominent in individuals having risk alleles AA as compared to protective alleles TT and heterozygous alleles AT as far as FTO gene is concerned [61,62].…”

Section: Fat Mass and Obesity (Fto) Genementioning

confidence: 99%

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

Shahid¹,

Jawed²

2024

Novel Topics in the Diagnosis, Treatment, and Follow-Up of Nephritis, Nephrotic Syndrome, and Nephrosis

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The recent unprecedented pandemic COVID-19 has blatantly exposed the healthcare system globally. The increasing rate of mortality and morbidity/co-morbidity were observed due to an interplay of COVID-19 infection with chronic diseases like diabetes, cancers, CVDs, respiratory and mental illness. According to World Health Organization, diabetes kills 1.7 million people annually. The prevalence and incidence of diabetes mellitus, representing >90% of all cases of diabetes and its complications, are increasing rapidly. The International Diabetes Federation has estimated that the number of people with diabetes is expected to rise from 366 million in 2011 to 552 million by 2030 if no urgent action is taken. Diabetes is a leading cause of kidney disease. About one in three adult diabetic patients has kidney disease, that is, diabetic nephropathy. In search for the risk and causes of diabetes and its complications such as diabetic nephropathy, research has now advanced to the molecular level. Genetics, epigenetics, genomics, proteomics, and metabolomics are opening ways to a new and deeper understanding of bodily processes and are providing the tools for more precisely targeted interventions when their function is disturbed. Similarly, tobacco use, physical inactivity, the harmful use of alcohol, and unhealthy diets all increase the risk of developing diabetic nephropathy. This chapter will focus on analyzing recently researched and published biochemical, genetic, nutritional, and lifestyle factors in various populations to ascertain the interplay of a wide variety of modifiable and non-modifiable factors, which will help delay and/or prevent the development of kidney disease in diabetes.

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Section: Fat Mass and Obesity (Fto) Genementioning

confidence: 99%

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

Shahid¹,

Jawed²

2024

Novel Topics in the Diagnosis, Treatment, and Follow-Up of Nephritis, Nephrotic Syndrome, and Nephrosis

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“…Some recent studies have also revealed its association with HTN in different population. [16][17][18][19] So keeping this in view, it is the need of time to unveil its association with HTN in Pakistani population.…”

Section: Introductionmentioning

confidence: 99%

Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population

Tabassum¹,

Mushtaq²,

Anwar³

et al. 2021

PJMHS

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Background: Hypertension is a medical condition that often occurs parallel to diabetes and obesity. Previously, the role of fat mass and obesity associated (FTO) gene rs9939609 polymorphism (c.46-23525T>A) with obesity has been reported while prevalence and etiological differences exist among different regions and ethnic groups. Aim: To investigate the association of FTO rs9939609 SNP with hypertension in Pakistani population. Study design: Cross-sectional study. Place and duration of study: Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan from 1st January 2019 to 31st December 2020. Methodology: One hundred and ten diagnosed hypertension patients along with 128 healthy volunteers were selected randomly. The single nucleotide polymorphism was analyzed using Amplified Refractory Mutation System-Polymerase Chain Reaction. Results: In hypertension patients, females were found to be relatively more affected and average blood pressure lies in stage 1. However, we found no significant difference in genotypic frequencies of FTO rs9939609; TT (22.6%), AA (39.6%) and AT (37.8%) and TT (17.18%), AA (39.06%), and AT (43.75%) among HT and controls, respectively. The p and OR values for risk type genotype (AA) are 0.4697 and 0.7700 (95% CI=0.3788-1.565), respectively. Subsequently, the high percentage (60.0 %) of risk genotype (AA) was found in obese-body mass index in hypertension patients. Conclusion: FTO rs9939609 single nucleotide polymorphism may not be a genetic risk factor associated with onset of hypertension directly and is linked with obesity in Pakistani patients. Keywords: FTO, Hypertension, Obesity, Pakistani patients, rs9939609

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The Role of FTO Gene Alleles on the Diet and Metabolic Risk Factors in the Subjects with Diabetes

Cited by 2 publications

References 25 publications

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

The Risk for the Development of Diabetic Nephropathy: Interplay of Biochemical, Genetic, Nutritional and Lifestyle Factors

Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population

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