The Role of Free Radicals in Chronic Rhinosinusitis

Abstract

Free radical-induced damage, if present, was the same in infected and control tissues in this pilot investigation into the pathophysiologic characteristics of human chronic rhinosinusitis.

Protective effects of apocynin on damaged testes of rats exposed to methotrexate

“…As seen from our histological examinations in testes, MTX caused severe damage such as the formation of vacuolizations in germinal epithelium, undulations in basal lamina, spilled immature germ cells in lumen of seminiferous tubules, congestions in interstitial space, and increased apoptotic index, and APO significantly improved these changes. Our findings support other studies on the effects of MTX [32]. Although apoptosis increased in the MTX group, it decreased in the MTX + APO treatment groups, suggesting an antiapoptotic feature of APO.…”

“…Oxidative stress is one of the major factors in MTX-induced damage for many organs [28][29][30][31]. The most important mechanism in the formation of tissue damage due to free oxygen radicals is the peroxidation of lipids (LPO) in cell membranes [32] and LPO can be used as a marker of tissue damage. MDA is one of the degradation products of LPO.…”

“…Apoptosis is known to play an important role on spermatogenesis in human testis [55][56][57], and the increase of apoptosis cause deterioration of spermatogenesis [30]. Numerous studies have reported that apoptosis is an important indicator of damage to spermatogenic cells by drugs of chemotherapy [11,32,35,58]. Chemotherapeutic drugs such as cisplatin, Adriamycin and MTX caused the depletion and degeneration of germ cells in rats [10,11,13,24,31,34,35,58,59].…”

Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp

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Effect of Ginkgo Leaf Parenteral Solution on Blood and Cochlea Antioxidant and Immunity Indexes in OM Rats

“…Although transient, species such as the superoxide radical and the hydroxyl radical can overcome natural antioxidant defenses, altering proteins, nucleic acids, and lipids (lipid peroxidation). This results in cell injury or death, subsequent tissue damage and, ultimately, a chronic disease state [ 22 ]. Therefore, the generation of ROS by various reactions becomes important as it may enhance the development of a disease in which one of the factors in the etiology of the disease is oxidative stress [ 23 ].…”