The Role of Fibrosis in Osteoarthritis Progression

Rim, Yeri Alice

doi:10.3390/life11010003

Cited by 64 publications

(69 citation statements)

References 114 publications

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“…TNC is a component of the extracellular matrix and is involved with organ fibrosis, inflammation, and cardiovascular disease ( Golledge et al., 2011 ; Yasuda et al., 2018 ). The formation of fibrocartilage and fibrosis in the joint is a major contributor to the degenerative changes in osteoarthritis ( Rim and Ju, 2020 ). Further, elevated levels of TGF-β signaling are associated with the pathological and fibrosis changes ( van der Kraan, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Boer¹,

Hatzikotoulas²,

Southam³

et al. 2021

Cell

241

159

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Summary Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation.

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Section: Discussionmentioning

confidence: 99%

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Boer¹,

Hatzikotoulas²,

Southam³

et al. 2021

Cell

241

159

View full text Add to dashboard Cite

show abstract

“…OA is a whole-joint disease that affects muscle, subchondral bone, cartilage, ligaments, and synovial tissue. [12][13][14] Four distinct synoviopathies have been reported to emerge during OA, namely, hyperplastic, inflammatory, fibrotic, and detritus-rich forms. 15 Synovial fibrosis is characterised by excessive proliferation of FLS, differentiation to myofibroblast-like cells, and ECM synthesis.…”

Section: Synovial Fibrosis In Osteoarthritismentioning

confidence: 99%

Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis

Maglaviceanu

Kapoor

2021

Wound Repair Regeneration

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The synovial membrane undergoes a variety of structural changes throughout the pathogenesis of osteoarthritis (OA), including the development of fibrosis. Fibroblastlike synoviocytes (FLS) are a heterogenous cell population of the synovium that are suggested to drive the fibrotic response, but the exact mechanisms associated with their activation in OA remain unclear. Once activated, FLS are suggested to acquire a myofibroblast-like phenotype that drives fibrogenesis through excessive extracellular matrix (ECM) component deposition and an enhanced contractile function. In this review, we define FLS in the synovium, discuss how select extracellular or endogenous factors potentially induce their activation in OA, and describe how the activity of myofibroblast-like cells affects the structure of the synovial membrane.

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“…OA presents as cartilage degeneration, remodelling of the subchondral bone and localised inflammation [ 4 ]. The emerging evidence suggests, in the most part, that synovitis and fibrosis plays an important role in the pathogenesis of OA and is related to clinical symptoms and structural progression [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Markers of Synovial Inflammation, Matrix Turnover and Symptoms in Knee Osteoarthritis: A Cross-Sectional Study

Yang

Thudium

Bay‐Jensen

et al. 2021

Cells

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To investigate the association between markers of synovial inflammation and matrix turnover (MRI-based and serum biomarkers) and knee symptoms in established knee osteoarthritis (KOA). This cross-sectional study utilised data from a randomised, multicentre placebo-controlled trial (UK-VIDEO) of vitamin D therapy in symptomatic KOA. Data on serum biomarkers, type III collagen degradation (C3M), metabolite of C-reactive protein (CRPM) and cartilage oligomeric matrix protein (COMP), were available at baseline whilst contrast-enhanced (CE) MRI data were acquired in a subsample at baseline and annually. Knee symptoms were assessed using WOMAC at all visits. We examined the cross-sectional association between knee symptoms and three MRI-based and three serum markers of synovitis and matrix turnover, respectively. A total of 447 participants were included in the serum and 136 participants in the MRI analyses. MRI-defined medial perimeniscal synovitis was positively associated with knee pain and, suprapatellar and medial perimeniscal synovitis with knee function in multivariate analysis. We observed a statistically significant, negative association between a higher concentration of serum C3M and CRPM and knee pain, respectively. Furthermore, the highest CRPM quartile was negatively associated with knee function. Our findings suggest that, in established painful radiographic KOA, MRI-defined medial perimeniscal and suprapatellar synovitis were positively associated with knee symptoms. Serum-based C3M and CRPM markers were negatively associated with knee symptoms. Pain fluctuations are common in KOA and a better understanding of the relationship between markers of synovitis and matrix turnover and knee symptoms would facilitate a more accurate assessment of temporal changes in disease progression.

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The Role of Fibrosis in Osteoarthritis Progression

Cited by 64 publications

References 114 publications

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis

Association between Markers of Synovial Inflammation, Matrix Turnover and Symptoms in Knee Osteoarthritis: A Cross-Sectional Study

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