2013
DOI: 10.1016/j.lfs.2012.05.015
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Abstract: The endogenous cannabinoid anandamide (AEA) exerts the majority of its effects at CB1 and CB2 receptors and is degraded by fatty acid amide hydrolase (FAAH). FAAH KO mice and animals treated with FAAH inhibitors are impaired in their ability to hydrolyze AEA and other non-cannabinoid lipid signaling molecules, such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). AEA and these other substrates activate non- cannabinoid receptor systems, including TRPV1 and PPAR-α receptors. In this mini review, we … Show more

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Cited by 37 publications
(32 citation statements)
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References 64 publications
(84 reference statements)
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“…The reasons for these species differences are not known, and it is not clear what species of laboratory animal will provide the best predictor of effects in humans. Nevertheless, given that substantial species-related differences exist (see also Muldoon et al, 2013), it could be valuable to determine the effects of FAAH inhibitors using behavioral models of nicotine reward in non-human primates that are phylogenetically closer to humans. Furthermore, as most previous research has involved a single chemical entity, URB597, it would also be valuable to investigate newer FAAH inhibitors with improved properties.…”
Section: Introductionmentioning
confidence: 99%
“…The reasons for these species differences are not known, and it is not clear what species of laboratory animal will provide the best predictor of effects in humans. Nevertheless, given that substantial species-related differences exist (see also Muldoon et al, 2013), it could be valuable to determine the effects of FAAH inhibitors using behavioral models of nicotine reward in non-human primates that are phylogenetically closer to humans. Furthermore, as most previous research has involved a single chemical entity, URB597, it would also be valuable to investigate newer FAAH inhibitors with improved properties.…”
Section: Introductionmentioning
confidence: 99%
“…Vanilloid type 1 channel (also known as transient receptor potential vanilloid type 1-TRPV1) is a nonselective cation channel that has been suggested to be involved in several neurobiological processes such as fear/anxiety, drug addiction and pain [1][2][3][4][5][6]. The role of TRPV1 in pain modulation has been shown through intracerebral injections of vanilloid compounds in animals exposed to various nociceptive tests (e.g., tail-flick and plantar tests [1,2,7]).…”
Section: Introductionmentioning
confidence: 99%
“…Accumulating evidence indicates that the endocannabinoid system (EC) plays an important role in the reinforcing properties of drugs of abuse, predominantly through neuromodulatory function in the mesolimbic system (Maldonado et al 2006; Parolaro et al 2007; Solinas et al 2008; Muldoon et al 2013). The EC system consists of two cannabinoid receptor subtypes, as well as endogenous ligands and enzymes responsible for their biosynthesis and degradation (Di Marzo 2009).…”
Section: Introductionmentioning
confidence: 99%