The Role of Environmental Disruptor Chemicals in the Development of Non Communicable Disease

Zarean, Maryam; Poursafa, Parinaz

doi:10.1007/978-3-030-10616-4_3

Cited by 14 publications

(13 citation statements)

References 51 publications

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“…The adverse effects of agricultural pesticides derived from their endocrine disruptive activity that may affect the thyroid and the reproductive, nervous, and adipose systems were investigated [100][101][102].…”

Section: Pesticidesmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

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Section: Pesticidesmentioning

confidence: 99%

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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“…Although obesity has a hereditary component, current epidemics cannot be attributed to genetic alterations in the Responsible Editor: Lotfi Aleya population since the human genome has not altered in such a short period. Environmental contaminants, without a doubt, are a major contributor to the rise in obesity as a risk factor for noncommunicable illnesses (Zarean and Poursafa 2019;Amin et al 2019b).…”

Section: Introductionmentioning

confidence: 99%

“…Environmental risk factors such as pollution, water, air, soil, exposure to chemicals are involved in causing a variety of diseases (Yousefi et al 2018). Environmental chemicals may be a major motivator for a variety of illnesses, especially in children, and these compounds may interact with genetic and epigenetic systems, affecting the body's natural growth (Zarean and Poursafa 2019;Amin et al 2018d). EDCs are substances that affect endocrine function and are among these pollutants (Kolšek et al 2015;Vela-Soria et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Association of urinary triclosan, methyl triclosan, triclocarban, and 2,4-dichlorophenol levels with anthropometric and demographic parameters in children and adolescents in 2020 (case study: Kerman, Iran)

Nasab

Rajabi

Mirzaee

et al. 2022

Environ Sci Pollut Res

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Endocrine-disrupting chemicals (EDCs) can be a major risk factor for noncommunicable illnesses, especially when children are exposed to them. The purpose of this study was to assess the urine concentrations of triclosan (TCS), methyl triclosan (MTCS), triclocarban (TCC), and 2,4-dichlorophenol (2,4-DCP) and its association with anthropometric and demographic parameters in children and adolescents aged 6-18 living in Kerman, Iran, in 2020. A GC/MS instrument was used to measure the concentrations of the analytes. TCS, MTCS, TCC, and 2,4-DCP geometric mean concentrations (µg/L) were 4.32 ± 2.08, 1.73 ± 0.88, 4.66 ± 10.25, and 0.19 ± 0.14, respectively. TCS, MTCS, TCC, and 2,4-DCP were shown to have a positive and significant association with BMI z-score and BMI (p-value < 0.01). TCS and MTCS have a positive, strong, and substantial association (p-value < 0.01, r = 0.74). There was no significant association between the waist circumference (WC) and the analytes studied. In addition, there was a close association between analyte concentration and demographic parameters (smoking, education, income, etc.) overall. In Kerman, Iran, the current study was the first to look into the association between TCS, MTCS, TCC, and 2,4-DCP analytes and anthropometric and demographic data. The levels of urinary TCS, MTCS, TCC, 2,4-DCP, and anthropometric parameters in children and adolescents are shown to have a significant association in this study. However, because the current study is cross-sectional and it is uncertain if a single experiment accurately reflects long-term exposure to these analytes, more research is needed to determine the impact of these analyses on the health of children and adolescents.

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“…Some of the factors affecting cardiovascular diseases include age, sex, diet, physical activity, and exposure to EDCs [ 20 , 21 ]. Exposure to EDCs at an early age can lead to chronic diseases that, if accompanied by improper lifestyle such as inactivity, unhealthy nutrition, increases the risk of chronic diseases [ 13 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…e main causes of obesity are genetic factors, inactivity, diet, and environmental pollutants [13][14][15]. Environmental pollutants include the role of endocrine-disrupting chemicals (EDCs) (such as phthalates, parabens, triclosan, triclocarban, and diphenols) in the development of chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Urinary Triclocarban and 2,4‐Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran

Nasab

Mirzaee

Hashemi

et al. 2022

Journal of Environmental and Public Health

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Exposure to Endocrine-Disrupting Chemicals (EDCs) at an early age can lead to chronic diseases. 2,4-Dichlorophenol (2,4-DCP) and Triclocarban (TCC) are among EDCs that disrupt the endocrine system and alter the body's metabolism. In the present study, the hypothesis that exposure to 2,4-DCP and TCC affects obesity and predictors of cardiovascular diseases was investigated. Fasting Blood Sugar (FBS), Total Cholesterol (TC), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL (tests were performed on 79 children and adolescents. Also, blood pressure, Body Mass Index (BMI), and BMI z-score were measured to examine the hypothesis. Urinary concentrations of TCC and 2,4-DCP were measured by Gas Chromatography-Mass Spectrometry (GC/MS). Mean concentrations of TCC and 2,4-DCP (µg/L) were higher in obese individuals (5.50 ± 2.35, 0.29 ± 0.13, respectively). After adjusting for possible confounding factors, the results showed an increase in TCC concentration among girls and a decrease in 2,4-DCP among boys with increasing age. The 2,4-DCP concentration among girls increased by 0.007 and 0.01 units with a one-unit increase in Diastolic Blood Pressure (DBP) and FBS, respectively. There was a significant relationship between TCC and TG (Odds Ratio (OR) = 1.02, p -value = 0.007), LDL (OR = 1.05, p -value = 0.003), and HDL (OR = 0.88, p -value = 0.002). There was also a significant relationship between 2,4-DCP and TG (OR = 1.02, p -value = 0.002), LDL (OR = 1.12, p -value = 0.007), and HDL (OR = 0.92, p -value = 0.02). Exposure to TCC and 2,4-DCP can increase some heart risk factors and increase the risk of cardiovascular diseases and obesity. However, to confirm the results of the present study, it is necessary to conduct further studies, such as cohort and case-control studies, with a larger sample size to examine the causal relationships.

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The Role of Environmental Disruptor Chemicals in the Development of Non Communicable Disease

Cited by 14 publications

References 51 publications

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Association of urinary triclosan, methyl triclosan, triclocarban, and 2,4-dichlorophenol levels with anthropometric and demographic parameters in children and adolescents in 2020 (case study: Kerman, Iran)

Measurement of Urinary Triclocarban and 2,4‐Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran

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