The Role of Early Stressors in Child Health and Mental Health Outcomes

Identification of biopsychological trait markers in functional neurological disorders

“…Thereby, dysregulation of morning cortisol secretion might represent a downregulation of the HPA axis following initial high levels of cortisol in response to long-term stress. 67 A proposed mechanism of action is the suppression of the negative feedback inhibition of cortisol. 33 , 34 Under normal health conditions, an acute stressor would activate the HPA axis and subsequent cortisol secretion through the amygdala.…”

The Impact of Hearing Impairment on the Life Trajectories of Aboriginal Children in Remote Australia: Protocol for the Hearing Loss in Kids Project

“…For example, lead ingestion is a well-established risk factor for cognitive deficits across the life course, largely because lead disrupts neurotransmitter regulation of synaptic development in the brain. 92 Although most lead exposure is related to lead-based paint, soil, and dust, 93 recent problems have been detected from contaminated consumer products, including toys. 94 Physical and built environments.…”

U.S. Health in International Perspective: Shorter Lives, Poorer Health

“…Fifth, adversities during childhood and adolescence may cultivate dysfunctional traits (such as poor self-control, limited social skills, lack of perseverance and resilience, and shortsightedness), maladjusted personalities, and susceptibility to antisocial behavior (Caspi, 2000;Caspi and Moffit, 1995; Center on the Developing Child at Harvard University, 2010; Dozier and Peloso, 2006;Elder and Shanahan, 2007;Felitti et al, 1998;Knudsen et al, 2006;Trzesniewski et al, 2006). Stress may alter gene expression in ways that predispose children to specific behavioral phenotypes (Caspi et al, 2002(Caspi et al, , 2003Taylor et al, 2006).…”