The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

Payandeh, Zahra; Tazehkand, Abbas Pirpour; Azargoonjahromi, Ali; Almasi, Faezeh; Bahrami, Armina Alagheband

doi:10.1186/s12575-021-00158-4

Cited by 8 publications

(3 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dendritic cells treated with IL-10 have been found to release exosomes and reduce the severity of RA ( 86 ). In addition, dc exosomes treated with IL-10 prevented the invasion of RA in mice and reduced the severity of existing arthritis ( 87 ).…”

Section: Applications Exosomes In Inflammatory Diseasesmentioning

confidence: 99%

Role of stem cell derivatives in inflammatory diseases

Yang

Peng

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are pluripotent stem cells of mesodermal origin with the ability of self-renewal and multidirectional differentiation, which have all the common characteristics of stem cells and the ability to differentiate into adipocytes, osteoblasts, neuron-like cells and other cells. Stem cell derivatives are extracellular vesicles(EVs) released from mesenchymal stem cells that are involved in the process of body’s immune response, antigen presentation, cell differentiation, and anti-inflammatory. EVs are further divided into ectosomes and exosomes are widely used in degenerative diseases, cancer, and inflammatory diseases due to their parental cell characteristics. However, most diseases are closely related to inflammation, and exosomes can mitigate the damage caused by inflammation in terms of suppressing the inflammatory response, anti-apoptosis and promoting tissue repair. Stem cell-derived exosomes have become an emerging modality for cell-free therapy because of their high safety and ease of preservation and transportation through intercellular communication. In this review, we highlight the characteristics and functions of MSCs-derived exosomes and discuss the regulatory mechanisms of MSCs-derived exosomes in inflammatory diseases and their potential applications in clinical diagnosis and therapy.

show abstract

Section: Applications Exosomes In Inflammatory Diseasesmentioning

confidence: 99%

Role of stem cell derivatives in inflammatory diseases

Yang

Peng

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…This suppression is done through the regulation of both endogenous T cells and APCs activity, MHC class II-dependent, and an antigen-specific pathway. Exosomes generated from DCs had a similar or even stronger immunosuppressive impact in comparison with their original secreting cells [ 176 , 193 ]. It has been revealed that the indoleamine-pyrrole 2, 3-dioxygenase (IDO) enzyme which degrades tryptophan, has an immunosuppressive capability in a variety of conditions, such as RA.…”

Section: Exosome and Rheumatic Arthritismentioning

confidence: 99%

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

et al. 2022

Self Cite

View full text Add to dashboard Cite

Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into the extracellular periphery by a variety of cells such as neoplastic cells. Given that exosomes have unique properties, they can be used as vectors and carriers of biological and medicinal particles like drugs for delivering to the desired areas. The proteins and RNAs being encompassed by the circulating exosomes in B-cell malignancies are deemed as the promising sources for diagnostic and prognostic biomarkers, as well as therapeutic agents. Exosomes can also provide a “snapshot” view of the tumor and metastatic landscape at any particular time. Further, clinical research has shown that exosomes are produced by immune cells such as dendritic cells can stimulate the immune system, so these exosomes can be used in antitumor vaccines. Despite the great potential of exosomes in the fields of diagnostic and treatment, further studies are in need for these purposes to reach a convergence notion. This review highlights the applications of exosomes in multiple immune-related diseases, including chronic lymphocytic leukemia, multiple sclerosis, and arthritis rheumatoid, as well as explaining sundry aspects of exosome therapy and the function of exosomes in diagnosing diseases.

show abstract

“…The diverse response to therapy by individual patients may also relate to the tumor microenvironment (TME). Inflammation is a biological process that combines innate and adaptive immune responses with metabolism and various activities that affect cell and organelle integrity and survival ( 7 , 8 ). It has long been recognized that inflammation has a paradoxical effect on tumors ( 9 – 11 ).…”

Section: Introductionmentioning

confidence: 99%

An inflammation-related subtype classification for analyzing tumor microenvironment and clinical prognosis in colorectal cancer

Pei,

Gao,

2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundThe inflammatory response plays an essential role in the tumor microenvironment (TME) of colorectal cancer (CRC) by modulating tumor growth, progression, and response to therapy through the recruitment of immune cells, production of cytokines, and activation of signaling pathways. However, the molecular subtypes and risk score prognostic model based on inflammatory response remain to be further explored.MethodsInflammation-related genes were collected from the molecular signature database and molecular subtypes were identified using nonnegative matrix factorization based on the TCGA cohort. We compared the clinicopathological features, immune infiltration, somatic mutation profile, survival prognosis, and drug sensitivity between the subtypes. The risk score model was developed using LASSO and multivariate Cox regression in the TCGA cohort. The above results were independently validated in the GEO cohort. Moreover, we explored the biological functions of the hub gene, receptor interacting protein kinase 2 (RIPK2), leveraging proteomics data, in vivo, and in vitro experiments.ResultsWe identified two inflammation-related subtypes (inflammation-low and inflammation-high) and have excellent internal consistency and stability. Inflammation-high subtype showed higher immune cell infiltration and increased sensitivity to common chemotherapeutic drugs, while inflammation-low subtype may be more suitable for immunotherapy. Besides, the two subtypes differ significantly in pathway enrichment and biological functions. In addition, the 11-gene signature prognostic model constructed from inflammation-related genes showed strong prognostic assessment power and could serve as a novel prognostic marker to predict the survival of CRC patients. Finally, RIPK2 plays a crucial role in promoting malignant proliferation of CRC cell validated by experiment.ConclusionsThis study provides new insights into the heterogeneity of CRC and provides novel opportunities for treatment development and clinical decision making.

show abstract

The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

Cited by 8 publications

References 119 publications

Role of stem cell derivatives in inflammatory diseases

Role of stem cell derivatives in inflammatory diseases

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

An inflammation-related subtype classification for analyzing tumor microenvironment and clinical prognosis in colorectal cancer

Contact Info

Product

Resources

About