The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

Lai, Lo; Shin, Ga Yoon; Qiu, Hongyu

doi:10.3390/ijms21228504

Cited by 37 publications

(20 citation statements)

References 86 publications

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“…Accordingly, eukaryotic cell cycle regulation integrates a huge multitude of internal and external signals to optimize survival. Failures in these processes reduce cell survival and, in higher metazoans, lead to cancer, and other diseases ( Moriel-Carretero et al, 2019 ; She et al, 2019 ; Klemm et al, 2020 ; Lai et al, 2020 ; Matellán and Monje-Casas, 2020 ; Niwa, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System

Delgado-Román

Muñoz-Centeno

2021

Front. Mol. Biosci.

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Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane traffic, among many others, are strictly regulated to ensure functional success. Such systems or vital processes do not work and adjusts independently of each other. It is required to ensure coordination among them which requires communication, or crosstalk, between their different elements through the establishment of complex regulatory networks. Distortion of this coordination affects, not only the specific processes involved, but also the whole cell fate. However, the connection between some systems and cell fate, is not yet very well understood and opens lots of interesting questions. In this review, we focus on the coordination between the function of the three nuclear RNA polymerases and cell cycle progression. Although we mainly focus on the model organism Saccharomyces cerevisiae, different aspects and similarities in higher eukaryotes are also addressed. We will first focus on how the different phases of the cell cycle affect the RNA polymerases activity and then how RNA polymerases status impacts on cell cycle. A good example of how RNA polymerases functions impact on cell cycle is the ribosome biogenesis process, which needs the coordinated and balanced production of mRNAs and rRNAs synthesized by the three eukaryotic RNA polymerases. Distortions of this balance generates ribosome biogenesis alterations that can impact cell cycle progression. We also pay attention to those cases where specific cell cycle defects generate in response to repressed synthesis of ribosomal proteins or RNA polymerases assembly defects.

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Section: Introductionmentioning

confidence: 99%

Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System

Delgado-Román

Muñoz-Centeno

2021

Front. Mol. Biosci.

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“…Klf6 encodes a transcription factor that plays a role in several developmental processes such as cell proliferation and differentiation [31]. Cdk20 , decreased in Taf4b- deficient ProSpg, encodes a positive regulator of the cell cycle by activating CDK2 and cyclin D [32]. Many other TAF4b-bound genes of interest were identified in only one replicate or were not a DEG in the E16.5 RNA-seq data ( Fig S4 ).…”

Section: Resultsmentioning

confidence: 99%

TAF4b Transcriptional Regulation During Cellular Quiescence of Developing Prospermatogonia

Gura

Bartholomew

Abt

et al. 2022

Preprint

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Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and long-term mammalian spermatogenesis. While these spermatogenic precursor cells undergo the characteristic transitions of cycling and quiescence, the transcriptional events underlying these developmental hallmarks remain unknown. Here we investigated the expression and function of TAF4b in the timely development of mouse ProSpg using an integration of gene expression profiling and chromatin mapping. We find that Taf4b mRNA expression is elevated during the transition of M-to-T1 ProSpg and Taf4b-deficient ProSpg are delayed in their entry into quiescence. Gene ontology, protein network analysis, and chromatin mapping demonstrate that TAF4b is both a direct and indirect regulator of cell cycle-related gene expression programs during ProSpg quiescence. By comparing the transcriptome changes in male and female Taf4b-deficient embryonic germ cells, we revealed that TAF4b promotes sex-independent and -dependent gene expression pathways, highlighting its unique and critical role in the fertility of both sexes.

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“…Surprisingly, Eriodictyol causes dramatic inhibition of p21. Some reports suggest p21 promotes carcinogenesis and tumor development by promoting transcription of proteins with mitogenic and anti-apoptotic properties [52] , [53] , [54] . Eriodictyol also inactivates Claspin in cancer cells, which plays a vital role in shifting the tumor cell response from cell cycle arrest to induction of apoptotic cell death in response to prolonged DNA replication arrest or the persistence of DNA damage [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%