2004
DOI: 10.1590/s0100-879x2004000400013 View full text |Buy / Rent full text
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Abstract: Abstract8-Methoxy psoralen (8-MOP) exerts a short-term (24 h) mitogenic action, and a long-term (48-72 h) anti-proliferative and melanogenic action on two human melanoma cell lines, SK-Mel 28 and C32TG. An increase of intracellular calcium concentration was observed by spectrofluorometry immediately after the addition of 0.1 mM 8-MOP to both cell lines, previously incubated with calcium probe fluo-3 AM (5 µM). The intracellular Ca 2+ chelator BAPTA/AM (1 µM) blocked both early (mitogenic) and late (anti-prolif… Show more

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