The Role of C-Reactive Protein in the Diagnosis of Neonatal Sepsis

Hofer, Nora; Müller, Wilhelm; Resch, Bernhard

doi:10.5772/54255

Cited by 14 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 The possible explanations for the suboptimal diagnostic accuracy include the potential for false-positive results if CRP levels are increased by triggers, such as inflammation due to extravasation, cholestasis, or gastrointestinal pathology. 44 Conversely, serum CRP levels may not increase, or increase only slowly, in some infants with infec- tion, particularly very preterm infants with coagulasenegative staphylococcal bacteremia. 13,45…”

Section: Discussionmentioning

confidence: 99%

Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, an elevated CRP can be a physiological response to the stress of delivery, peaking at 13 mg/L on the 2nd day of life 20. CRP can also be raised in non-infection conditions such as intraventricular haemorrhage.…”

Section: Clinical Questionsmentioning

confidence: 99%

“…CRP can also be raised in non-infection conditions such as intraventricular haemorrhage. Studies have suggested that serial CRP measurements have a higher sensitivity for sepsis than one-off measurements 20. One study considered babies who had full septic screens (including LP) for maternal risk factors.…”

Section: Clinical Questionsmentioning

confidence: 99%

How to use… lumbar puncture in children

Schulga

Grattan

Napier

et al. 2015

Arch Dis Child Educ Pract Ed

View full text Add to dashboard Cite

Lumbar puncture (LP) is a useful diagnostic tool in a wide spectrum of paediatric clinical situations. A common indication is to rule out a serious intracranial infection in a febrile child. Success rate can be optimised by proper positioning, appropriate technique and enhanced operator's skill in performing the procedure. The purpose of this review is to explore the indications and contraindications for performing paediatric LP, to describe the anatomical and physiological knowledge required to maximise success rates and to describe complications and their management. We will also provide advice on requesting various cerebrospinal fluid studies, interpretation of results and clinical situations in which LP may be indicated.

show abstract

“…Nora Hofer et al concluded in their study that CRP was most widely available, most studied and most used laboratory tests for neonatal bacterial infection and despite the continuing emergence of new infection markers it still plays a central role in the diagnosis of early onset sepsis of the neonates [9]. CRP has the advantage of being well characterized in numerous studies and was found to be the best marker to diagnose sepsis in neonates [10].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ischemia modified albumin in patients of sepsis

Sahoo¹,

Patra²,

Pradhan³

et al. 2015

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Sepsis is characterized as the combination of pathologic infection and physiological changes known collectively as the Systemic Inflammatory Response Syndrome. This response results in physiological alterations that occur at the capillary endothelial level. In the early stages, the clinical manifestations of this process are nonspecific and it is often underappreciated in clinical practices. These shortcomings in both culture and available blood tests have driven researchers to find other more specific markers. So this study was conducted to find out a suitable endogenous marker which can detect sepsis and predict its severity. A cross sectional (case control) study was carried out with 76 cases divided into two groups depending on the features of systemic inflammatory response syndrome and diagnosed cases of sepsis. We tried to evaluate the Ischemia Modified Albumin and serum CRP in septic patients and compare it with age matched normal subjects. The above parameters were also compared with physical parameters like age & sex, temperature, respiratory rate, heart rate, blood pressure & total lecocytes count.

show abstract

The Role of C-Reactive Protein in the Diagnosis of Neonatal Sepsis

Cited by 14 publications

References 64 publications

Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants

Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants

How to use… lumbar puncture in children

Evaluation of ischemia modified albumin in patients of sepsis

Contact Info

Product

Resources

About