The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior

Stengel, Andreas; Karasawa, Hiroshi; Taché, Yvette

doi:10.1016/j.yhbeh.2015.05.009

Cited by 31 publications

(29 citation statements)

References 111 publications

(152 reference statements)

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“…In the ARH, a large proportion of SST-expressing cells coexpressed GLP-1R. SST is associated with the inhibition of growth hormone (73) and a range of extrapituitary effects, including body temperature and visceral functions (74)(75)(76)(77). When delivered centrally, SST increases food intake (78,79).…”

Section: Discussionmentioning

confidence: 99%

Semaglutide lowers body weight in rodents via distributed neural pathways

Gabery¹,

Salinas²,

Paulsen³

et al. 2020

JCI Insight

323

305

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Section: Discussionmentioning

confidence: 99%

Semaglutide lowers body weight in rodents via distributed neural pathways

Gabery¹,

Salinas²,

Paulsen³

et al. 2020

JCI Insight

323

305

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“…Somatostatin is a multifunctional neuropeptide produced by the periventricular nucleus of the hypothalamus, the ARC, and other neuronal populations (Guillemin and Gerich, 1976). It binds to receptors located in various brain nuclei involved in feeding regulation, notably the ARC, and it regulates food intake in various mammalian species (Lotter et al, 1981;Danguir, 1988;Fehlmann et al, 2000;Stengel et al, 2010Stengel et al, , 2015. Interestingly, independent studies have reported that Kp (Revel et al, 2006a;Smith et al, 2008), RFRP-3 (Revel et al, 2008;Smith et al, 2008), NPY (Lakhdar-Ghazal et al, 1995Reuss and Olcese, 1995;Skinner and Herbison, 1997), b-endorphin (Roberts et al, 1985;Ebling and Lincoln, 1987), and somatostatin (Webb et al, 1985;Herwig et al, 2012;Klosen et al, 2013;Dumbell et al, 2015) display significant variations in the brain of different mammalian species placed in artificial long or short photoperiods.…”

mentioning

confidence: 99%

Coordinated seasonal regulation of metabolic and reproductive hypothalamic peptides in the desert jerboa

Talbi

Klosen

Laran-Chich

et al. 2016

J of Comparative Neurology

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Jerboa (Jaculus orientalis) is a semi-desert rodent displaying strong seasonal variations in biological functions in order to survive harsh conditions. When environmental conditions become unfavorable in early autumn, it shuts down its reproductive axis, increases its body weight, and finally hibernates. In spring, the jerboa displays opposite regulations, with a reactivation of reproduction and reduction in body weight. This study investigated how genes coding for different hypothalamic peptides involved in the central control of reproduction (Rfrp and Kiss1) and energy homeostasis (Pomc, Npy, and Somatostatin) are regulated according to seasons in male jerboas captured in the wild in spring or autumn. Remarkably, a coordinated increase in the mRNA level of Rfrp in the dorso/ventromedial hypothalamus and Kiss1, Pomc, and Somatostatin in the arcuate nucleus was observed in jerboas captured in spring as compared to autumn animals. Only Npy gene expression in the arcuate nucleus displayed no significant variations between the two seasons. These variations appear in line with the jerboa's seasonal physiology, since the spring increase in Rfrp and Kiss1 expression might be related to sexual reactivation, while the spring increase in genes encoding anorexigenic peptides, POMC, and somatostatin may account for the reduced body weight reported at this time of the year. J. Comp. Neurol. 524:3717-3728, 2016. © 2016 Wiley Periodicals, Inc.

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“…The role of SST in the regulation of food intake and energy store and expenditure is most controversial. Previous studies support the pro-and anti-satiety effect of SST that depends on species, doses, and mode of administration [26,163,168]. It is not well understood if SST regulates satiety via direct or indirect mechanisms.…”

Section: Role Of Somatostatin and Its Receptors In Satietymentioning

confidence: 98%

“…A summary of the physiological actions of SST and associated receptor subtypes in target sites is shown in Figure 2. In addition to the anti-proliferative effect in peripheral tissue, SST exerts a significant role in food intake and drinking behaviour via activation of specific receptors [26,121,122,[163][164][165]. Besides the prominent role in the regulation of hormonal secretion, SSTR subtypes play a critical role in modulation of complex downstream signal transduction pathways [2,3].…”

Section: Somatostatin Receptorsmentioning

confidence: 99%

“…The underlying molecular mechanisms of SST mediated anti-obesity role and its five receptor subtypes are not well understood. Accordingly, understanding the role of SST and the neurohormonal pathways involved in satiety and obesity may assist with developing novel SST analogues and potential treatment strategies [13,25,26]. The role of SST in food intake and appetite has been reviewed previously; however, SST mediated regulation of other critical peripheral determinants of food-seeking behaviour is not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity

Kumar

Singh

2020

IJMS

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Obesity is one of the major social and health problems globally and often associated with various other pathological conditions. In addition to unregulated eating behaviour, circulating peptide-mediated hormonal secretion and signaling pathways play a critical role in food intake induced obesity. Amongst the many peptides involved in the regulation of food-seeking behaviour, somatostatin (SST) is the one which plays a determinant role in the complex process of appetite. SST is involved in the regulation of release and secretion of other peptides, neuronal integrity, and hormonal regulation. Based on past and recent studies, SST might serve as a bridge between central and peripheral tissues with a significant impact on obesity-associated with food intake behaviour and energy expenditure. Here, we present a comprehensive review describing the role of SST in the modulation of multiple central and peripheral signaling molecules. In addition, we highlight recent progress and contribution of SST and its receptors in food-seeking behaviour, obesity (orexigenic), and satiety (anorexigenic) associated pathways and mechanism.Contrary to obesity, satiety is a sense of fullness due to ephemeral lack of interest in further ingestion of food, which eventually leads to the suppression of appetite. Fullness is supposed to have a vital role in weight management because it will impact the frequency and amount of food and drink consumed later [53]. The feeling of satiety is a well-organized and biologically oriented process [54,55]. Satiety is a well-articulated process which reduces gastric distension and cholecystokinin (CCK) release in gut post ingestion of nutrients and importantly has been associated with signals from periphery via vagal afferent fibers that terminate in nucleus of the tractus solitaries (NTS) in the brain stem [56]. Besides, leptin, a hormone secreted by adipocytes, is also associated with satiety signals and studies further indicate that satiety response to CCK that was blocked in leptin receptor-deficient rat was regained following restoration of the leptin receptor in arcuate nucleus (ARC) [57][58][59]. Studies also support the role of NTS vagus afferent in response to leptin [60,61]. Feeling satiated will, in the long run, smother the inclination for cravings and lead to lesser consumption of food in the next meal. Satiety is not a response; it involves a complex mechanism for its operation, which includes the crucial role of the hypothalamus and peripheral hormones and determines energy expenditure [62]. Measurement of satiation can be done either directly by assessing food intake or indirectly by subjectively rating the urge for appetite [63]. Schwartz et al. demonstrated that hypothalamus is the central brain region responsible for adiposity signal; however, it is not an active participant in satiety [64]. It is interesting to note that most satiety associated information is relayed to NTS afferent fibers from the vagus nerve and afferent from GIT through the spinal cord. Mechanical or chemical stimula...

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The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior

Cited by 31 publications

References 111 publications

Semaglutide lowers body weight in rodents via distributed neural pathways

Semaglutide lowers body weight in rodents via distributed neural pathways

Coordinated seasonal regulation of metabolic and reproductive hypothalamic peptides in the desert jerboa

Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity

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