The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis

Dou, Shu-Hui; Cui, Yu; Huang, Shu-Ming; Zhang, Bo

doi:10.3389/fnhum.2022.924155

Cited by 23 publications

(14 citation statements)

References 77 publications

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“…We also examined NPC module 4 as it is associated with gene expression and transcription pathways and found that BDNF and RPE65 are involved in this module. BDNF, stimulates intracellular signaling and controls neurogenesis that is critical for neuronal survival, morphogenesis, and plasticity, and has connections with 45 genes in this module. No notable change was observed in the expression level of the BDNF.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Transcriptomic Investigation of Rett Syndrome Reveals Increasing Complexity Trends from Induced Pluripotent Stem Cells to Neurons with Implications for Enriched Pathways

Odabasi,

Yanasik,

Saglam-Metiner

et al. 2023

ACS Omega

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Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder that has no cure apart from symptomatic treatments. While intense research efforts are required to fulfill this unmet need, the fundamental challenge is to obtain sufficient patient data. In this study, we used human transcriptomic data of four different sample types from RTT patients including induced pluripotent stem cells, differentiated neural progenitor cells, differentiated neurons, and postmortem brain tissues with an increasing in vivo-like complexity to unveil specific trends in gene expressions across the samples. Based on DEG analysis, we identified F8A3, CNTN6, RPE65, and COL19A1 to have differential expression levels in three sample types and also observed previously reported genes such as MECP2, FOXG1, CACNA1G, SATB2, GABBR2, MEF2C, KCNJ10, and CUX2 in our study. Considering the significantly enriched pathways for each sample type, we observed a consistent increase in numbers from iPSCs to NEUs where MECP2 displayed profound effects. We also validated our GSEA results by using single-cell RNA-seq data. In WGCNA, we elicited a connection among MECP2, TNRC6A, and HOXA5. Our findings highlight the utility of transcriptomic analyses to determine genes that might lead to therapeutic strategies.

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Section: Resultsmentioning

confidence: 99%

Comprehensive Transcriptomic Investigation of Rett Syndrome Reveals Increasing Complexity Trends from Induced Pluripotent Stem Cells to Neurons with Implications for Enriched Pathways

Odabasi,

Yanasik,

Saglam-Metiner

et al. 2023

ACS Omega

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“…When myostatin activation is elevated, such as during COVID-19 infection, the SMAD complexes become less unavailable to the BMPs, and the skeletal muscles lose proteins. Taken together, all events during new onset acute sarcopenia in COVID-19 infection induced muscular autophagy via increased mitochondrial dysfunction and decreased mitochondrial biogenesis, which decreases skeletal muscles synthesis and increases not only myofibrillar breakdown but also skeletal muscles degradation [18,[140][141][142].…”

Section: Myostatinmentioning

confidence: 99%

Organokines in COVID-19: A Systematic Review

Barbalho,

Minniti,

Miola

et al. 2023

Cells

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Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes.

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“…In the substantia nigra, BDNF might also improve the differentiation and survival of dopaminergic neurons [ 284 ]. Moreover, BDNF has a significant contribution in memory, synaptic plasticity, and neuronal survival [ 285 ]. Various small molecules have been developed that have the capacity to target BDNF receptors [ 286 , 287 ].…”

Section: Antiapoptotic Agents In the Treatment Of Neurodegenerative D...mentioning

confidence: 99%

Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review

Dailah

2022

Molecules

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Neurodegenerative disorders (NDs) include Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) and the common feature of NDs is the progressive death of specific neurons in the brain. Apoptosis is very important in developing the nervous system, nonetheless an elevated level of cell death has been observed in the case of NDs. NDs are different in terms of their neuronal vulnerability and clinical manifestations, however they have some overlapping neurodegenerative pathways. It has been demonstrated by several studies with cell lines and animal models that apoptosis has a significant contribution to make in advancing AD, ALS, HD, and PD. Numerous dying neurons were also identified in the brains of individuals with NDs and these conditions were found to be linked with substantial cell loss along with common characteristics of apoptosis including activation of caspases and cysteine-proteases, DNA fragmentation, and chromatin condensation. It has been demonstrated that several therapeutic agents including antioxidants, minocycline, GAPDH ligands, p53 inhibitors, JNK (c-Jun N-Terminal Kinase) inhibitors, glycogen synthase kinase-3 inhibitor, non-steroidal anti-inflammatory drugs, D2 dopamine receptor agonists, FK506, cell cycle inhibitors, statins, drugs targeting peroxisome proliferator-activated receptors, and gene therapy have the potential to provide protection to neurons against apoptosis. Therefore, the use of these potential therapeutic agents might be beneficial in the treatment of NDs. In this review, we have summarized the pathways that are linked with apoptotic neuronal death in the case of various NDs. We have particularly focused on the therapeutic agents that have neuroprotective properties and the potential to regulate apoptosis in NDs.

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The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis

Cited by 23 publications

References 77 publications

Comprehensive Transcriptomic Investigation of Rett Syndrome Reveals Increasing Complexity Trends from Induced Pluripotent Stem Cells to Neurons with Implications for Enriched Pathways

Comprehensive Transcriptomic Investigation of Rett Syndrome Reveals Increasing Complexity Trends from Induced Pluripotent Stem Cells to Neurons with Implications for Enriched Pathways

Organokines in COVID-19: A Systematic Review

Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review

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