Abstract:Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, biofilm formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for biofilm inhibitors will … Show more
“…The microbial communities within the enclosure comprises of an altered phenotype which in turn physiologically demarcates them from planktonic microorganisms [6]. Clinical studies have confirmed the role of biofilms in causing human infections which accounts up to 60% [7]. Biofilm formation and development is a complex mechanism and a dynamic process which provides a better understanding on biofilms and will lead to novel therapeutic approaches.…”
“…The microbial communities within the enclosure comprises of an altered phenotype which in turn physiologically demarcates them from planktonic microorganisms [6]. Clinical studies have confirmed the role of biofilms in causing human infections which accounts up to 60% [7]. Biofilm formation and development is a complex mechanism and a dynamic process which provides a better understanding on biofilms and will lead to novel therapeutic approaches.…”
“…A woman who has MRSA may give it to the baby from birth and breast-feeding. Some strains can cause chronic infections and gain increased resistance to antimicrobial agents through biofilm formation (Chen and Wen, 2011). Researchers have investigated the strategies employed by microorganisms to produce biofilms and to understand the pathogenesis.…”
Section: Study Of Biofilm Formation By Molecular Methods (Detection Ofmentioning
“…Staphylococci initially attach either to host tissue or to the surface of a medical device via interaction with surface proteins or molecules respectively [5,16]. The attached bacteria then proliferate and accumulate into multilayered three dimensional cell clusters, which are embedded in an amorphous extracellular polymeric material.…”
Section: Staphylococcus Aureus Biofilms and Role Of Extracellular Promentioning
Bacterial biofilms are multicellular structures akin to citadels which have individual bacterial cells embedded within a matrix of a self-synthesized polymeric or proteinaceous material. Since biofilms can establish themselves on both biotic and abiotic surfaces and that bacteria residing in these complex molecular structures are much more resistant to antimicrobial agents than their planktonic equivalents, makes these entities a medical and economic nuisance. Of late, several strategies have been investigated that intend to provide a sustainable solution to treat this problem. More recently role of extracellular proteases in disruption of already established bacterial biofilms and in prevention of biofilm formation itself has been demonstrated. The present review aims to collectively highlight the role of bacterial extracellular proteases in biofilm disruption of Gram positive bacteria. The article includes description of anti-biofilm activity of both endogenously produced extracellular proteases as well as extraneously applied proteases against biofilms formed by important Gram positive pathogens.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.