The role of autofluorescence, photodynamic diagnosis and Photodynamic therapy in malignant tumors of the duodenum

Krupka, Magdalena; Bartusik‐Aebisher, Dorota; Strzelczyk, Natalia; Latos, Magdalena; Sieroń, Aleksander; Cieślar, Grzegorz; Aebisher, David; Czarnecka, Magdalena; Kawczyk‐Krupka, Aleksandra; Latos, Wojciech

doi:10.1016/j.pdpdt.2020.101981

Cited by 8 publications

(6 citation statements)

References 74 publications

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“…The reports on collagen follow ancient works addressing to the great importance of the highly fluorescing collagen in the submucosa of multilayered epithelia in the setup of strategies aiming to facilitate the in situ detection of neoplasia in hollow organs. In fact, the growing of neoplasia causes a thickening of mucosa and a disappearance of submucosa, resulting in a lowering the signal rising at the tissue surface which can be detected via endoscopy, as currently performed in the clinics by means of commercial devices [266,[325][326][327][328][329]. Notably, a direct relationship has been also reported between autofluorescence imaging data, histology and alterations in genes related to cancer cell proliferation [330].…”

Section: Normal and Altered Cell And Tissuesmentioning

confidence: 98%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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Organisms belonging to all life kingdoms may have the natural capacity to fluoresce. Autofluorescence events depend on the presence of natural biomolecules, namely endogenous fluorophores, with suitable chemical properties in terms of conjugated double bonds, aromatic or more complex structures with oxidized and crosslinked bonds, ensuring an energy status able to permit electronic transitions matching with the energy of light in the UV-visible-near-IR spectral range. Emission of light from biological substrates has been reported since a long time, inspiring unceasing and countless studies. Early notes on autofluorescence of vegetables have been soon followed by attention to animals. Investigations on full living organisms from the wild environment have been driven prevalently by ecological and taxonomical purposes, while studies on cells, tissues and organs have been mainly promoted by diagnostic aims. Interest in autofluorescence is also growing as a sensing biomarker in food production and in more various industrial processes. The associated technological advances have supported investigations ranging from the pure photochemical characterization of specific endogenous fluorophores to their possible functional meanings and biological relevance, making fluorescence a valuable intrinsic biomarker for industrial and diagnostic applications, in a sort of real time, in situ biochemical analysis. This review aims to provide a wide-ranging report on the most investigated natural fluorescing biomolecules, from microorganisms to plants and animals of different taxonomic degrees, with their biological, environmental or biomedical issues relevant for the human health. Hence, some notes in the different sections dealing with different biological subject are also interlaced with human related issues. Light based events in biological subjects have inspired an almost countless literature, making it almost impossible to recall here all associated published works, forcing to apologize for the overlooked reports. This Review is thus proposed as an inspiring source for Readers, addressing them to additional literature for an expanded information on specific topics of more interest.

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Section: Normal and Altered Cell And Tissuesmentioning

confidence: 98%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

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“…Researchers have proposed algorithms that increase the effectiveness of detecting abnormal tissue, especially dysplastic and neoplastic, but also inflammed tissue in pulmonology, gastrology, and urology [ 24 , 25 ]. High-fluorescence fields are interlaced with low-fluorescence areas that are close to normal, or clearly lower, and correlated with the NCV index [ 26 , 27 , 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

et al. 2021

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Chronic and infected leg ulcers (LUs) are painful, debilitating, resistant to antibiotics, and immensely reduce a patient’s quality of life. The purpose of our study was to demonstrate the efficacy of photodynamic therapy (PDT) for the treatment of infected chronic LUs. Patients were randomized into two experimental groups: the first group received 5-aminolevulinic acid photodynamic therapy (ALA-PDT) (10 patients), and the second group of 10 patients received local octenidine dihydrochloride (Octenilin gel) exposed to a placebo light source with an inserted filter that mimiced red light. In the PDT group, we used 20% ALA topically applied for 4 hrs and irradiation from a Diomed laser source with a wavelength of 630 nm at a fluency of 80 J/cm2. ALA-PDT was performed 10 times during a 14-day hospitalization in 10 patients of both sexes aged 40–85 years with chronic leg ulcers. Treatments were carried out at 3-week intervals for 3–5 cycles. At 8-month follow-up with the PDT group, complete remission (CR) was obtained in four patients (40%), partial response (>50% reduction in ulcer diameter) in four patients (40%), and no response in two patients (20%) who additionally developed deterioration of the local condition with swelling, erythema, and inflammation. To assess the degree of pain during the trials, we used a numeric rating scale (NRS). From the preliminary results obtained, we concluded that PDT can be used to treat leg ulcers as a minimally invasive and effective method with no serious side effects, although further studies on a larger group of patients with LUs are warranted.

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“…Photodynamic tumor therapy has many advantages, including high tumor selectivity and enrichment, minimal damage to normal tissues, and repeatability . It has become a research hotspot in treating malignant tumors and has achieved promising clinical results in treating superficial tumors. − …”

Section: Applications Of Ce6 In Photodynamic Therapymentioning

confidence: 99%

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

et al. 2023

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Chlorin e6 (Ce6) has been extensively researched and developed as an antitumor therapy. Ce6 is a highly effective photosensitizer and sonosensitizer with promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and light therapy for tumors. Ce6 is also being studied for other applications in fluorescence navigation, antibacterials, and plant growth regulation. Here we review the role and research status of Ce6 in tumor therapy and the problems and challenges of its clinical application. Other biomedical effects of Ce6 are also briefly discussed. Despite the difficulties in clinical application, Ce6 has significant advantages in photodynamic therapy (PDT)/sonodynamic therapy (SDT) against cancer and offers several possibilities in clinical utility.

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The role of autofluorescence, photodynamic diagnosis and Photodynamic therapy in malignant tumors of the duodenum

Cited by 8 publications

References 74 publications

Light and Autofluorescence, Multitasking Features in Living Organisms

Light and Autofluorescence, Multitasking Features in Living Organisms

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

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