The role of anti-cyclic citrullinated peptide (CCP) antibodies in early detection of rheumatoid arthritis: an overview of the INOVA Diagnostics, Inc. QUANTA Lite CCP assays

Gilliam, Brooke E; Moore, Terry L.

doi:10.1517/17530059.2012.694423

Cited by 5 publications

(3 citation statements)

References 39 publications

(26 reference statements)

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“…A meta-analysis [46] has shown that the pooled sensitivities of ACPA and RF are similar, but ACPA positivity is more specific for RA than IgM RF, IgG RF, or IgA RF positivity [61] and more specific for early RA than IgM RF [62]. On the other hand, sensitivity is reduced because positivity for both ACPA and RF is a more stringent criterion than positivity for either alone [46]; combining ACPA and RF positivity is more permissive in terms of sensitivity because the antibodies complement each other, especially for early RA [63–66]. …”

Section: Rfs and Rheumatoid Arthritismentioning

confidence: 99%

Rheumatoid Factors: Clinical Applications

2013

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Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy.

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Section: Rfs and Rheumatoid Arthritismentioning

confidence: 99%

Rheumatoid Factors: Clinical Applications

2013

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“…As generally accepted, RF and anti-CCP antibodies are important markers for the diagnosis and prognosis of RA ( 53 ). Numerous clinical data have shown that RF is not specific for RA diagnosis, and approximately 30% to 45% of patients with RA do not have RF ( 54 ). Anti-CCP antibody is an index of the prognosis of RA and is extremely specific for RA diagnosis ( 55 ).…”

Section: Resultsmentioning

confidence: 99%

Circular RNA circNUP214 Modulates the T Helper 17 Cell Response in Patients With Rheumatoid Arthritis

et al. 2022

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Circular RNAs (circRNAs) are important transcriptional regulators of genome expression that participate in the pathogenesis of human diseases. Mechanistically, circRNAs, as competitive endogenous RNAs (ceRNAs), can sponge microRNAs (miRNAs) with miRNA response elements. A previous study identified that hsa_circ_0089172 (circNUP214) is abnormally expressed in Hashimoto’s thyroiditis. However, the role of circNUP214 in rheumatoid arthritis (RA) remains unclear. In total, 28 RA patients and 28 healthy controls were enrolled in this study. We found that circNUP214 is an abundant and stable circRNA in RA patients that can potentially differentiate RA patients from healthy subjects. Additionally, the elevated levels of IL-23R positively correlated with circNUP214 expression. The knockdown of circNUP214 resulted in the reduction of IL-23R at both transcriptional and translational levels in human CD4+ T cells. The proportion of circulating Th17 cells and the transcript levels of IL-17A were increased in RA patients and were both positively correlated with IL-23R expression. Moreover, positive correlations between the transcript levels of circNUP214 and the percentage of Th17 cells and the transcript levels of IL-17A were observed in RA patients. The downregulation of circNUP214 decreased the proportion of Th17 cells and the transcript levels of IL-17A in vitro. Furthermore, circNUP214 functioned as a ceRNA for miR-125a-3p in RA patients. Taken together, our results indicate that elevated levels of circNUP214 contribute to the Th17 cell response in RA patients.

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“…Both RF and anti-CCP2 have similar sensitivities for the diagnosis of RA but anti-CCP2 is more specific [ 14 ]. Anti-CCP2 is positive in 20%-30% of RA patients who are negative for RF [ 15 ]. A systemic review and meta-analysis that included 37 studies of anti-CCP2 positive patients and 50 studies of RF positive patients showed the pooled sensitivities of RF and anti-CCP2 to be 69% and 67%, and 85% and 95%, respectively [ 16 ].…”

Section: Reviewmentioning

confidence: 99%