2008
DOI: 10.1016/j.biomaterials.2008.03.042
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Abstract: Peripheral nerve regeneration across long nerve gaps is clinically challenging. Autografts, the standard of therapy, are limited by availability and other complications. Here, using rigorous anatomical and functional measures, we report that aligned polymer fiber-based constructs present topographical cues that facilitate the regeneration of peripheral nerves across long nerve gaps. Significantly, aligned but not randomly oriented fibers elicit regeneration, establishing that topographical cues can influence e… Show more

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Cited by 401 publications
(353 citation statements)
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References 22 publications
(26 reference statements)
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“…Previous studies have reported on reinnervation after single-lumen nerve tube repair using various methods [2,7,8,[32][33][34]. The main goal of this research was to investigate whether multichannel nerve conduits present a permissive microenvironment for axonal growth.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Previous studies have reported on reinnervation after single-lumen nerve tube repair using various methods [2,7,8,[32][33][34]. The main goal of this research was to investigate whether multichannel nerve conduits present a permissive microenvironment for axonal growth.…”
Section: Discussionmentioning
confidence: 99%
“…Though an autologous nerve graft is the gold standard of nerve graft repair, it has several disadvantages, including the need for an extra incision, loss of donor nerve function, mismatch in size between the donor nerve and the injured nerve, and a limited availability of donor nerve. A diverse array of synthetic and natural materials has been studied in peripheral nerve repair, but these studies have shown limited success [1][2][3][4][5][6][7][8][9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…This study showed that the introduction of an aligned matrix significantly increased Schwann cell migration and the rate of axonal growth after five days in culture [4]. Studies by Kim et al and later by Clements et al similarly allude to more efficient migration of Schwann cells and axonal regeneration through the addition of topographical guidance cues [18,21,41]. Similarly the introduction of structured fibres may have increased rates of migration and growth during the initial stages of repair.…”
Section: Discussionmentioning
confidence: 57%
“…(Li, Rickett et al 2009). (G) Dorsal root ganglia neurons extend along electrospun nanofibers (Kim, Haftel et al 2008).…”
Section: Nervous Systemmentioning
confidence: 99%
“…For instance, Kim et al created a 17mm gap defect in rat sciatic nerve and used an artificial conduit to bridge the damage site (Kim, Haftel et al 2008). Acrylonitrile-co-methylacrylate (PAN-MA) polymer was spun into aligned or unaligned configurations.…”
Section: Nervous Systemmentioning
confidence: 99%