The role of 18F-FDG PET-CT in the detection of unknown primary malignancy: a retrospective study

Yaylalı, Olga; Kıraç, Fatma Suna; Yüksel, Doğangün

doi:10.3906/sag-1502-99

Cited by 7 publications

(6 citation statements)

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“…16 Overall, PET-CT has a sensitivity of 43%-88%, specificity of 33%-88%, and a detection rate of 15%-50% in the management of CUP (Table 4). [17][18][19][20][21][22] A recent systematic review of 7 studies (246 patients) demonstrates an overall sensitivity of 44% and specificity of 97%. 23 Completing this imaging modality before diagnostic endoscopy (nasopharyngoscopy, direct laryngoscopy, esophagoscopy, and bronchoscopy) is of the utmost importance, as highlighted by the NCCN guidelines.…”

Section: Type and Timing Of Imagingmentioning

confidence: 99%

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AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site

2017

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This article reviews the clinical practice guidelines for head and neck oncology focusing on the management of head and neck cancers of unknown primary (CUP). The primary purpose of this series is to raise awareness of the current guidelines in head and neck oncology by reviewing the recommendations and the evidence supporting such recommendations, particularly those published by the National Comprehensive Cancer Network (NCCN). We review the importance of a thorough history and physical examination, the impact of the American Joint Committee on Cancer (AJCC) eighth edition changes and the importance of immunohistochemistry, the timing and type of imaging, the role of panendoscopy and tonsillectomy (palatine and lingual), and the role of surgery, radiation, and chemotherapy in the primary management of these tumors.

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Section: Type and Timing Of Imagingmentioning

confidence: 99%

“…Overall, PET‐CT has a sensitivity of 43%‐88%, specificity of 33%‐88%, and a detection rate of 15%‐50% in the management of CUP (Table ) . A recent systematic review of 7 studies (246 patients) demonstrates an overall sensitivity of 44% and specificity of 97% …”

Section: Introductionmentioning

confidence: 99%

AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site

2017

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“…Upoređujući lokalizaciju primarnog tumora, utvrđenu 18 FDG PET/CT, vidimo da se naši rezultati poklapaju sa brojnim objavljenim studijama (12)(13)(14)(15). U svima njima najčešća lokalizacija primarnog tumora bila su pluća.…”

Section: Diskusijaunclassified

“…U svima njima najčešća lokalizacija primarnog tumora bila su pluća. U nekim studijama, međutim, iako je najčešća lokalizacija primarnog tumora utvrđena 18 FDG PET/CT bila u plućima, zbog heterogenosti regije nije bilo moguće direktno postaviti dijagnozu lokalizacije primarnog tumora (15).…”

Section: Diskusijaunclassified

The role of 18FDG PET/CT in evaluation of unknown primary tumors

Marković¹,

Šobić-Šaranović²

2019

Medicinski podmladak

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Introduction: An unknown primary tumor (UPT) is defined as a biopsy-proven malignancy whose anatomic origin remains unidentified after diagnostic evaluation. The estimated incidence of unknown primary tumors is 2-7% of all malignancies. Aim: The aim of this study was to determine the role of 18 FDG PET/CT in the evaluation of primary tumor and its influence on therapeutic management. Material and methods: This retrospective study included 56 patients, which were examined in the PET center of Center for Nuclear Medicine (Clinical Center of Serbia), from May 2011 until September 2017. Examinations using 18 FDG on PET/CT system were done on all patients using a 64 slice Biograph True 64 PET/CT hybrid imaging system (Siemens Medical Solutions, USA). Image acquisition was done at least 60 minutes after applying the radiopharmaceutical (18 FDG), which have been applied after proper preparation of each patient. Results: The primary site of tumor was found in 23 (41%) patients, which is a statistically significant value 23/56, χ 2 1.78, p < 0.05. Conclusion: Considering the acquired results, 18 FDG PET/CT represents a significant advancement when it comes to non-invasive diagnostics of UPT.

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“…Наиболее часто применяемые рентгенологические методы визуализации могут выявить первичную локализацию опухоли лишь в 10-35% случаев. Низкая частота выявленной первичной опухоли может объясняться размером поражения, когда оно меньше, чем пространственное и контрастное разрешения применяемых методов рентгенологической диагностики [20]. Последовательное использование различных методов визуализации увеличивает время постановки правильного диагноза и своевременного начала лечения, а также может оказаться экономически затратным.…”

Section: Introductionunclassified

Assessment of Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Carcinoma of Unknown Primary

Yaremenko

Ruchyeva

Sinitsyn

2021

Vestn. rentgenol. radiol.

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Objectives: to assess the possibility of using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP); to determine the effectiveness of PET/CT for detecting a primary tumor lesion in patients with a histologically verified diagnosis of CUP and the contribution of PET/CT procedure to the process of disease staging in these patients.Material and methods. From September 2018 to March 2019, the retrospective study included a total of 187 patients (64 (34.2%) females and 123 (65.8%) males) diagnosed with CUP. The patients’ mean age was 61.9 ± 7.5 years. Before PET/CT, all the patients underwent puncture biopsy of at least one metastatic lesion, which histologically verified the malignant nature of the neoplasm. A number of conventional studies were also performed as part of an oncosearch to identify the nature of a primary cancer lesion.Results. Biopsy of lymph node metastases in 187 patients included in the study showed the following distribution according to the histological types of the tumor: 87 (46.5%) patients were diagnosed with squamous cell carcinoma, 15 (8%) with melanoma, 45 (24.1%) with undifferentiated carcinoma, 23 (12.3%) with adenocarcinoma, 17 (9.1%) with undifferentiated malignant neoplasm. The examination could identify a primary tumor site in 93 (49.7%) patients; no primary source was found in 94 (50.3%) patients. After PET/CT, there were no significant differences in the age of patients with and without CUP. PET/CT revealed new, previously undetected metastatic lesions in 93 cases, accounting for 49.7% of the entire sample. It is worth noting that after PET/CT, a change in the stage of tumor development tool place in 131 (70.1%) cases, which was associated with both the detection of the primary tumor and the identification of new metastatic lesions. The stage change was significantly more frequently observed in patients with detected CUP than in those with undetected CUP (100% vs. 40.4%; p < 0.001).Conclusion. PET/CT can more accurately determine the stage of cancer in a large proportion of patients with CUP. The technique is able to identify the primary tumor in a significant number of cases, which in turn affects treatment policy and prognosis in these patients. The use of PET/CT should be obligatorily included in the examination protocol for patients with CUP.

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The role of 18F-FDG PET-CT in the detection of unknown primary malignancy: a retrospective study

Abstract: 18F-FDG-PET/CT identified the primary tumor site well in 50% of our cases. We propose that 18F-FDG PET/CT imaging may help to accurately detect malignant lesions in patients with unknown primary tumors.

Cited by 7 publications

References 30 publications

AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site

AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site

The role of 18FDG PET/CT in evaluation of unknown primary tumors

Assessment of Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Carcinoma of Unknown Primary

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