The Risk of Hip Fracture After Initiating Antihypertensive Drugs in the Elderly

Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients

“…This result is consistent with the results observed in the report by Butt et al .,[25] which showed a nonstatistically significant increase in NOF of the hip (incidence rate ratio, 1.41; 95% CI , 0.65–3.05). However, some studies found that ARB use was associated with a statistically significant decrease in the risk of NOF development.…”

Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients

“…This result is consistent with the results observed in the report by Butt et al .,[25] which showed a nonstatistically significant increase in NOF of the hip (incidence rate ratio, 1.41; 95% CI , 0.65–3.05). However, some studies found that ARB use was associated with a statistically significant decrease in the risk of NOF development.…”

Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study

“…We found increased risk of hip fracture during the first 2 weeks of treatment with loop diuretics; similar findings have been reported by Berry et al for the initial 3 weeks of treatment with thiazides and loop diuretics [ 12 ], and by Butt et al for the 45 days immediate after a first prescription of various antihypertensive drugs (incidence rate ratio 1.43, 95 % CI 1.19–1.72) [ 11 ]. Although the numbers of hip fractures in these studies were relatively small and the findings must be interpreted with caution, the results are interesting because they are opposite to those with long-term drug use.…”

Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication

“…The relationship with falls persisted after adjusting for age, sex, frailty status, SBP, DBP, and other potential confounders suggesting that the extent of variability itself is likely to be the main factor increasing the risk of a fall. In keeping with reports from other studies mean levels of BP themselves were not related to the risk of falls 3–10,12–14,31,32 (Table S16).…”

Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients

“…This result is consistent with the results observed in the report by Butt et al .,[25] which showed a nonstatistically significant increase in NOF of the hip (incidence rate ratio, 1.41; 95% CI , 0.65–3.05). However, some studies found that ARB use was associated with a statistically significant decrease in the risk of NOF development.…”

Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study

“…We found increased risk of hip fracture during the first 2 weeks of treatment with loop diuretics; similar findings have been reported by Berry et al for the initial 3 weeks of treatment with thiazides and loop diuretics [ 12 ], and by Butt et al for the 45 days immediate after a first prescription of various antihypertensive drugs (incidence rate ratio 1.43, 95 % CI 1.19–1.72) [ 11 ]. Although the numbers of hip fractures in these studies were relatively small and the findings must be interpreted with caution, the results are interesting because they are opposite to those with long-term drug use.…”

Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication

“…The relationship with falls persisted after adjusting for age, sex, frailty status, SBP, DBP, and other potential confounders suggesting that the extent of variability itself is likely to be the main factor increasing the risk of a fall. In keeping with reports from other studies mean levels of BP themselves were not related to the risk of falls 3–10,12–14,31,32 (Table S16).…”

Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients

“…This result is consistent with the results observed in the report by Butt et al .,[25] which showed a nonstatistically significant increase in NOF of the hip (incidence rate ratio, 1.41; 95% CI , 0.65–3.05). However, some studies found that ARB use was associated with a statistically significant decrease in the risk of NOF development.…”

Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study

“…We found increased risk of hip fracture during the first 2 weeks of treatment with loop diuretics; similar findings have been reported by Berry et al for the initial 3 weeks of treatment with thiazides and loop diuretics [ 12 ], and by Butt et al for the 45 days immediate after a first prescription of various antihypertensive drugs (incidence rate ratio 1.43, 95 % CI 1.19–1.72) [ 11 ]. Although the numbers of hip fractures in these studies were relatively small and the findings must be interpreted with caution, the results are interesting because they are opposite to those with long-term drug use.…”

Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication

“…The relationship with falls persisted after adjusting for age, sex, frailty status, SBP, DBP, and other potential confounders suggesting that the extent of variability itself is likely to be the main factor increasing the risk of a fall. In keeping with reports from other studies mean levels of BP themselves were not related to the risk of falls 3–10,12–14,31,32 (Table S16).…”