The risk of herpes simplex virus and human cytomegalovirus infection during pregnancy upon adverse pregnancy outcomes: A meta-analysis

Shi, Ting-li; Huang, Li-Ju; Xiong, Yiquan; Zhong, Yan-Yun; Yang, Jinjun; Fu, Ting; Lei, Xie-Fen; Chen, Qing

doi:10.1016/j.jcv.2018.04.016

Cited by 36 publications

(19 citation statements)

References 56 publications

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“…Some but not all viral infections during pregnancy have been associated with adverse pregnancy outcomes. [ 11 ] An infection during early pregnancy may cause anything from spontaneous abortion[ 12 13 ] to a major congenital malformation. [ 14 ] Viral infection during pregnancy can also increase the risk of neurodevelopmental disorders during childhood, and of schizophrenia in later life.…”

Section: Pregnancy As a Special Field Of Concernmentioning

confidence: 99%

COVID-19 and lockdown: Delayed effects on health

Andrade

2020

Indian J Psychiatry

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Section: Pregnancy As a Special Field Of Concernmentioning

confidence: 99%

COVID-19 and lockdown: Delayed effects on health

Andrade

2020

Indian J Psychiatry

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“…Neonatal HSV is associated with significant morbidity and, if left untreated, high rates of mortality. HSV increases the risk of spontaneous abortion, premature birth, and stillbirth with an OR of 3.81, 3.83, and 1.78, respectively ( Shi et al, 2018 ). Central nervous system (CNS) associated infection accounts for 30% of neonatal HSV.…”

Section: Virusesmentioning

confidence: 99%

“…Approximately 90% of neonates with congenital CMV infection are asymptomatic but carry a long-term risk of sequelae ( Kagan and Hamprecht, 2017 ). CMV infection during pregnancy is a risk factor for spontaneous abortion, prematurity, and stillbirth, with an OR of 1.61, 1.86, and 5.74, respectively ( Shi et al, 2018 ). Permanent deafness, vision impairment, and neurologic disability are the most severe sequelae in surviving infants ( Davis et al, 2017 ).…”

Section: Virusesmentioning

confidence: 99%

Neurologic infections during pregnancy

Curcio

Shekhawat

Reynolds

et al. 2020

Handbook of Clinical Neurology

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Neurologic infections during pregnancy represent a significant cause of maternal and fetal morbidity and mortality. Immunologic alterations during pregnancy increase the susceptibility of the premature brain to damage. This chapter summarizes the epidemiology, pathophysiology, and clinical manifestations in the pregnant woman and the infant, and the diagnosis, treatment, and prevention of the major viral, parasitic, and bacterial infections known to affect pregnancy. These organisms include herpes virus, parvovirus, cytomegalovirus, varicella, rubella, Zika virus, toxoplasmosis, malaria, group B streptococcus, listeriosis, syphilis, and tuberculosis. There is an emphasis on the important differences in diagnosis, treatment, and fetal outcome between trimesters. An additional overview is provided on the spectrum of neurologic sequelae of an affected infant, which ranges from developmental delay to hydrocephalus and seizures.

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“…Modern development of molecular genetic technologies allows timely to diagnose hereditary diseases, which cause a significant part of reproductive losses (RL). And new global paradigms of medicine (Predictive, Personalized, Preventive and Participatory, or 4P) help to build a multilevel preventive system of hereditary genetic pathology, which can positively affect the level of RL in the early stages of ontogenesis (pregametic, presygotic, embryonic and fetal) [1,2]. For the solution of the whole task, the etiological factors and diagnostic markers for the destruction of human embryogenesis and development of the fetus (biochemical, molecular-genetic, cytogenetic, instrumental, etc.)…”

Section: Problem Descriptionmentioning

confidence: 99%

The Study of Social-Medical and Genetic Risks of Reproductive Losses

Алиева¹

2021

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Object of research: homozygous and heterozygous disorders of genes encoding the enzymes of the folate cycle, methylenetetrahydrofolate reductase (MTHFR) and methionine-synthase-reductase (MTRR). Solved problem: an in-depth study of genetically determined risk factor’s influence for reproductive losses associated with homozygous and heterozygous disorders of folate cycle genes. Main scientific results: in-depth study of genetically determined reproductive losses as a systemic phenomenon was held. The structural characteristics of reproductive losses in population and significant predominance of pathology in the pedigrees of those examined with a burdened obstetric history of reproductive losses were determined. Also, a significant increase in the chances of reproductive loss in patients with heterozygous and homozygous inheritance of MTHFR and MTRR genes was determined. A correlation effect on the degree of genomic polymorphism of the MTHFR and MTRR gene was noted. Area of practical use of research results: medical-genetic institutions. Innovative technological product: determination of genetically risk factors for growth of reproductive losses of the population associated with homozygous and heterozygous disorders of genes encoding the enzymes of the folate cycle (MTHFR C677T and MTRR A66G). Timely adjustment of folic acid levels allows to prevent birth defects and reduce reproductive losses Scope of application of the innovative technological product: clinical medical-genetic practice using the ability to determine the polymorphism of genes MTHFR and MTRR, which makes it possible to timely adjust the level of folic acid and prevent the reproductive losses.

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The risk of herpes simplex virus and human cytomegalovirus infection during pregnancy upon adverse pregnancy outcomes: A meta-analysis

Cited by 36 publications

References 56 publications

COVID-19 and lockdown: Delayed effects on health

COVID-19 and lockdown: Delayed effects on health

Neurologic infections during pregnancy

The Study of Social-Medical and Genetic Risks of Reproductive Losses

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