The risk of developing metastatic disease in colorectal cancer is related to CD105-positive vessel count

Romani, Antonello A.; Borghetti, Angelo F.; Río, Paolo Del; Sianesi, M; Soliani, P.

doi:10.1002/jso.20456

Cited by 52 publications

(43 citation statements)

References 44 publications

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“…The levels of endoglin obtained with the commercial ELISA kit were greater than those reported by Li [16], who used an indirect sandwich ELISA kit. At the same time they were about 8-fold lower than those reported in serum [31].…”

Section: Resultscontrasting

confidence: 69%

“…The number of endoglin-positive vessels was significantly associated with a decreased rate of overall survival [16].…”

Section: Discussionmentioning

confidence: 95%

“…It has been also reported as a valuable parameter predicting patients having an increased risk of developing metastatic disease [16]. It correlates with tissue expression of VEGF [17].…”

Section: Introductionmentioning

confidence: 97%

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Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients.

Myśliwiec¹,

Pawlak²,

Kukliński³

et al. 2009

Folia Histochem Cytobiol.

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Abstract:Colorectal cancer growth and spread is absolutely dependent on angiogenesis with vascular endothelial growth factor (VEGF) being the most important cytokine involved in the process. Endoglin, a membrane co-receptor for TGF-β, has recently emerged as a sensitive index of cancer stage. There is now sufficient evidence indicating that microvessel density assessed by endoglin-immunostaining correlates with stage of colorectal cancer and patient survival. An association of a soluble form of endoglin with lymph node and distant metastases has recently been reported in two studies. Both of them used local elaborated immunoassays for endoglin assessment. The aim of our study was to determine the efficacy of plasma endoglin, assessed using a commercial kit, as a marker of tumor spread and distant metastases in colorectal cancer patients. We studied 48 colorectal cancer patients, compared with 22 healthy subjects, using ELISA. We observed that colorectal cancer patients had increased plasma VEGF-A, but not endoglin levels. However, we found an association of plasma endoglin with the stage of malignancy. Endoglin levels were increased in metastasis-positive patients when compared to both metastasis-negative patients and healthy volunteers. Plasma endoglin correlated with VEGF-A, CEA and CA19.9. Endoglin assessment in plasma does not seem useful as a maker of colorectal cancer. Our observations indicate however that it might be helpful in selecting patients with metastatic disease.

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Section: Resultscontrasting

confidence: 69%

“…The number of endoglin-positive vessels was significantly associated with a decreased rate of overall survival [16].…”

Section: Discussionmentioning

confidence: 95%

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Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients.

Myśliwiec¹,

Pawlak²,

Kukliński³

et al. 2009

Folia Histochem Cytobiol.

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“…It has been reported in this study that angiogenesis was found to be activated in midstage lesions before the appearance of full-blown tumors suggesting that the formation of new blood vessels is essential for Clonal Expansion and formation of macroscopic tumors (Hanahan and Weinberg, 2000). But in the macroscopic tumor, the main factor affecting the density of blood vessels is the metabolic needs of tumor cells which usually increase with tumor progression (Sharma et al, 2005) Thus, in malignant tumors with severe invasiveness and progression, metabolic needs and consequently the development of blood vessels increases (Romani et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61±3.1) as compared to PA (0.46±0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7±10.8 respectively) compared to PA (50% and 0.78±0.2) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

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“…CD105 is a transforming growth factor beta (TGF-β) binding receptor preferentially expressed on endothelial cells (ECs) of all angiogenic tissues, including tumors, but weakly or not at all with those of normal tissues (Marioni et al, 2006) giving it the superiority as a marker with a greater specificity for tumor-induced angiogenesis. Moreover, its expression increased in the same time with the neo-angiogenic progression (Romani et al, 2006).…”

mentioning

confidence: 85%

Evaluation of Angiogenesis in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Comparison Between Anti-Cd105 and Anti-Cd31 Antibodies.

Farag¹,

Kasem²,

AboAzma³

et al. 2018

IJAR

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Background and Aim:The tumor-induced angiogenesis is used as a reliable marker for tumor progression and metastasis. CD105 has been suggested as a marker with a greater specificity for tumor-induced angiogenesis since it is strongly up-regulated on proliferating endothelial cells of newly formed blood vessels while it shows no or only weak expression in normal pre-existing ones unlike CD31 which can not differentiate the newly formed tumoral vessels from normal pre-existing ones. This study was designed to measure the microvessel density (MVD) in oral epithelial dysplasia and oral squamous cell carcinoma using CD105 and CD31. Methodology and Principal Findings: A total of 40 oral epithelial dysplasia and oral squamous cell carcinoma specimens were immunostained with CD105 and CD31. Then MVD was measured according to "hot spot method" in 3 high power microscopic fields at a magnification x200. The number of immunostained blood vessels increased from normal through dysplasia to carcinoma with a mean value of 1.5±0.5, 3.2±1 and 5.263±0.8 for CD105 and 3.6±1.02, 7.6±0.8 and 9.77±1.75 for CD31 respectively. CD31 showed positive immunoreaction in all blood vessels while CD105 revealed positive immunoreactivity only in the newly formed blood vessels while the native ones showed weak to negative immunoexpressions. Conclusion: CD105 can be considered as a more specific marker for measuring the tumor-induced angiogenesis compared to the commonly used panendothelial marker CD31.

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The risk of developing metastatic disease in colorectal cancer is related to CD105-positive vessel count

Cited by 52 publications

References 44 publications

Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients.

Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients.

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Evaluation of Angiogenesis in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Comparison Between Anti-Cd105 and Anti-Cd31 Antibodies.

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