The risk of cancer in relatives of patients with brain neoplasm

Sakas, Damian; Kalfakis, Nikolaos; Πάνας, Μάριος; Vassilopoulos, D.; Carvounis, Petros

doi:10.1007/bf01808618

Cited by 2 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous registry and case control studies have found an elevated risk for specific cancers particularly nervous system cancers (Hemminki et al, 2000, 2001; Malmer et al, 2003), or family history of cancer in first-degree relatives of persons with meningioma (Hill et al, 2004). A family study conducted by Sakas et al (1994) found no significant difference in family history of cancer between persons with benign or malignant brain neoplasms and healthy controls. Our population reported relatively high rates of nervous system cancers in first and second-degree relatives, compared to previous studies that have suggested elevated standard incidence ratios for nervous systems in first-degree family members of persons with meningioma (Hemminki and Li, 2004).…”

Section: Discussionmentioning

confidence: 94%

“…Though the sample size of this analysis is considerable considering the rarity of brain tumors, the small sample size results in some instability of the data produced by the analysis. Previous studies that have examined the relationship between family history and brain tumors have been based on populations between 3239 and 11,875 in registry-based studies (Malmer et al, 2003; Hemminki et al, 2007), 96 in case control studies (Hill et al, 2004), and 142 in family-based studies (Sakas et al, 1994). Previous studies examining the relationship between family history of cancer and glioma have been based on populations between 462 and 489 in case control studies (Wrensch et al, 1997; Hill et al, 2003), 20358 in registry-based studies (Malmer et al, 2003), and between 639 and 1476 in family-based studies (de Andrade et al, 2001; Scheurer et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between glioma and family history of cancer has been explored by several investigators, and family history of malignancy has been established as a risk factor for gliomas (Hemminki et al, 2000, 2001, 2007; Hemminki and Li, 2004). The studies that have looked into benign brain tumor subtypes primarily focus on meningioma and/or acoustic neuroma only, and while some have shown significant associations between family history of cancer and increased odds of a brain tumor, others have shown no association (Sakas et al, 1994; Louis and von Deimling, 1995; Maxwell et al, 1998; Hemminki et al, 2000, 2001; King and Gutmann, 2000; Hill et al, 2003, 2004; Malmer et al, 2003; Bacci et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Family History of Cancer in Benign Brain Tumor Subtypes Versus Gliomas

Ostrom¹,

McCulloh²,

Chen³

et al. 2012

Front. Oncol.

View full text Add to dashboard Cite

Purpose: Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with benign brain tumors and compare those to patients with gliomas. Methods: Newly diagnosed primary brain tumor patients were identified as part of the Ohio Brain Tumor Study. Each patient was asked to participate in a telephone interview about personal medical history, family history of cancer, and other exposures. Information was available from 33 acoustic neuroma (65%), 78 meningioma (65%), 49 pituitary adenoma (73.1%), and 152 glioma patients (58.2%). The association between family history of cancer and each subtype was compared with gliomas using unconditional logistic regression models generating odds ratios (ORs) and 95% confidence intervals. Results: There was no significant difference in family history of cancer between patients with glioma and benign subtypes. Conclusion: The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Family History of Cancer in Benign Brain Tumor Subtypes Versus Gliomas

Ostrom¹,

McCulloh²,

Chen³

et al. 2012

Front. Oncol.

View full text Add to dashboard Cite

show abstract

A comparison of the risks of leukaemia and non-Hodgkin's lymphoma in the first generation offspring of the Danish Thorotrast patients with those observed in other studies of parental pre-conception irradiation

Little¹,

Wakeford

Charles

et al. 1996

J. Radiol. Prot.

View full text Add to dashboard Cite

The high doses of alpha-particle radiation which Thorotrast delivers to the testes makes the study of offspring of patients, who were administered this diagnostic contrast medium, particularly relevant to the controversy regarding childhood leukaemia in the offspring of the male Sellafield workforce, as it has been suggested that the alpha-particle dose from actinides may, in part, account for the observed association between paternal pre-conception external irradiation and leukaemia. The risks of childhood leukaemia and non-Hodgkin's lymphoma found among the offspring of the male Danish cohort of neurosurgical patients injected with Thorotrast for cerebral arteriography are compared with those observed in the offspring of the Sellafield (western Cumbria), Ontario and Scottish radiation workers and in the offspring of the Japanese atomic bomb survivors. Risks are compared using linear and exponential forms of a relative risk model. The pre-conception exposure risks of leukaemia, or of leukaemia and non-Hodgkin's lymphoma, in the Danish study are statistically incompatible with the corresponding risks in the children of the Sellafield workforce ( P < 0.01), which is entirely due to incompatibility with the risks in the children of the Sellafield workforce born in Seascale ( P < 0.01). Indeed no cases arose in the Danish study. The statistical incompatibility between the offspring of the Danish patients and the Seascale-born offspring of the Sellafield workforce is independent of the models used and is insensitive to uncertainties in the gonadal dose estimates in the respective datasets or to uncertainties in the estimates of the background cancer rates in the Seascale and Danish populations. The risks of leukaemia and non-Hodgkin's lymphoma in the Danish dataset are statistically compatible with the risks observed in the offspring of the Sellafield workforce born elsewhere in western Cumbria and with those seen among the offspring of the Ontario or Scottish radiation workforces as well as with those in the offspring of the Japanese atomic bomb survivors. The statistical compatibilities of the leukaemia pre-conception exposure risks in these various groups are also independent of the models used. It is most unlikely that the Seascale childhood leukaemia cases are caused by paternal exposures to alpha-particle emitters such as plutonium. In each non-Seascale dataset the risks are consistent with there being no excess hazard of leukaemia associated with paternal pre-conception exposure to ionising radiation, and it would seem that the association seen for Seascale-born children should be attributed to chance.

show abstract

The risk of cancer in relatives of patients with brain neoplasm

Cited by 2 publications

References 11 publications

Family History of Cancer in Benign Brain Tumor Subtypes Versus Gliomas

Family History of Cancer in Benign Brain Tumor Subtypes Versus Gliomas

A comparison of the risks of leukaemia and non-Hodgkin's lymphoma in the first generation offspring of the Danish Thorotrast patients with those observed in other studies of parental pre-conception irradiation

Contact Info

Product

Resources

About