The risk of Bipolar Disorders in Multiple Sclerosis

Carta, Mauro Giovanni; Moro, Maria Francesca; Lorefice, Lorena; Trincas, Giuseppina; Cocco, Eleonora; Giudice, E. Del; Fenu, Giuseppe; Colom, Francesc; Marrosu, Maria Giovanna

doi:10.1016/j.jad.2013.11.008

Cited by 62 publications

(45 citation statements)

References 44 publications

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“…While WD is a rare genetic disease, reports from different parts of the world with relatively modest cases are necessary because the advance in understanding depends on the cumulative world experience with this disease. We must also consider that what has been shown in WD concerning the association with bipolar disorders may be close to what occurs in other neurological diseases such as Multiple sclerosis [28] or in autoimmune diseases with neurological localization such as systemic sclerosis [29,30] or autoimmune vasculitis [9]. In these disorders, the comorbidity with bipolar disorder has been found associated with worsening in the course of the disease and in patients' quality of life.…”

Section: Discussionmentioning

confidence: 82%

Homogeneous magnetic resonance imaging of brain abnormalities in bipolar spectrum disorders comorbid with Wilson's disease

Carta

Saba

Moro

et al. 2015

General Hospital Psychiatry

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Section: Discussionmentioning

confidence: 82%

Homogeneous magnetic resonance imaging of brain abnormalities in bipolar spectrum disorders comorbid with Wilson's disease

Carta

Saba

Moro

et al. 2015

General Hospital Psychiatry

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“…It is noteworthy that MS is a chronic disease characterized by clinical and neuroradiological heterogeneity, resulting in different MRI activity levels and lesion burdens, as well as various symptoms, including motor and sensory deficit, fatigue, vision loss, dysphagia [20], bowel/bladder incontinence, and cognitive and mood impairment [21,22]. Over the years, the criteria for MS diagnosis have changed [23,24]; currently, the 2010 revisions to the McDonald criteria are used [25].…”

Section: Discussionmentioning

confidence: 99%

A genetic study of the FMR1 gene in a Sardinian multiple sclerosis population

et al. 2015

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Multiple sclerosis (MS) is a complex autoimmune disease originated from the interplay between genetic and environmental factors. An overlap of clinical and neuroradiological parameters has been described between MS and an adult-onset neurodegenerative disorder, the fragile-X-associated tremor/ataxia syndrome (FXTAS). This syndrome is caused by a trinucleotide premutation expansion of a CGG sequence in the 55-200 repeat range, which is located in the fragile-X mental retardation 1 (FMR1) gene. Female premutation carriers have an increased propensity for immune-mediated disorders. Recently, a case of co-occurrence of MS and FXTAS was reported. Assuming that the premutation expansion may play a role in the MS susceptibility, we evaluated its frequency in a cohort of MS patients from Sardinia, an island characterized by a very high frequency of MS. Nuclear DNA was extracted by standard methods, purified with bisulfite treatment and then amplified twice by PCR with specific primers. Microsatellite analysis was performed and emizogotic subjects were sequenced. Clinical data of patients were also collected. Only 1/755 MS patients exhibited the premutation expansion with a heterozygosis pattern (30/58). No pathogenic repeat expansions (>200 repeats) were found in the entire cohort. Repeats labeled as the gray zone (45-60 repeats) were observed in 15/755 patients. No specific clinical features concerning disease course, disease activity, and disability were reported for these patients. Our results do not support a possible role for premutation or gray zone alleles in MS Sardinian patients. Further studies are needed to better understand the relationship between FXTAS and MS.

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“…8 Carta ve ark.nın çalışmasında da MS hastalarında depresyonun kontrol grubuna göre daha sık görüldüğü saptanmıştır. 9 Whitlock ve Siskind, engellilikleri aynı oranda olan 30 MS ve 30 diğer kronik nörolojik hastalığı olan hastaları karşılaştırmış; MS hastalarında nörolojik belirtilerin öncesinde ve sonrasında daha sık depresyon dönemleri geliştiğini saptamış-lardır. 10 Sullivan ve ark., MS hastalarının %52'sinin MS belirtilerinin öncesinde depresif dönemler geçirdiklerini, kronik sırt ağrısı olan hastalarda ise bu oranın %17 olduğunu belirlemişlerdir.…”

Section: Multi̇pl Skleroz Ve Majör Depresi̇f Bozuklukunclassified

“…47 Carta ve ark.nın çalışmasında ise MS hastalarında bipolar bozukluk görülme sıklığının %9,9 olduğu saptanmıştır. 9 Bu eş tanının yüksek olmasının sebebi; MS'de kullanı-lan tedaviler, beyindeki demiyelinizan lezyonlar, genetik ve psikolojik sorunlar gibi etkenlere bağlı olarak multifaktöriyeldir. İFN tedavisi daha sıklıkla depresyonla ilişkilendirilse de psikotik veya manik davranışın eşlik ettiği vakalar da bildirilmiştir .…”

Section: Multi̇pl Sklerozda Bi̇polar Bozuklukunclassified