The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Türkez, Hasan; Sönmez, Erdal; Turkez, Ozlem; Mokhtar, Yousef I.; Stefano, Antonio Di; Turgut, G.

doi:10.1590/s1516-89132014005000021

Cited by 26 publications

(4 citation statements)

References 61 publications

(57 reference statements)

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“…In terms of their X-ray mass attenuation capabilities, CaWO 4 versus WO 3 nanoparticles are quite comparable to each other, because the X-ray attenuation coefficient depends primarily on the atomic number and physical density of the material (rather than the crystal structure of the material) . Unlike other metal oxides, WO 3 nanoparticles have been shown to be nontoxic. , We have also confirmed that both uncoated and PEGylated (i.e., PEG–PLA-coated) CaWO 4 nanoparticles are nontoxic to cultured human cells (e.g., HN31 cells) (unpublished results). In the present paper, we report that the MTD of PEGylated CaWO 4 nanoparticles in mice is significantly higher than that of a commercial MRI contrast agent.…”

Section: Discussionsupporting

confidence: 58%

Nontoxic Formulations of Scintillation Nanocrystals for Use as X-ray Computed Tomography Contrast Agents

et al. 2016

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X-ray computed tomography (CT) is currently one of the most powerful, noninvasive, clinical in vivo imaging techniques, which has resulted from advances in both X-ray device and contrast enhancement technologies. The present study demonstrates, for the first time, that metal tungstates (such as CaWO) are promising contrast agents for X-ray, radiation, and CT imaging, because of the high X-ray mass attenuation of tungsten (W). We have developed a method of formulation, in which CaWO (CWO) nanoparticles (NPs) are encapsulated within a biocompatible poly(ethylene glycol-b-d,l-lactic acid) (PEG-PLA) block copolymer (BCP) capsule. We show that these PEG-PLA-encapsulated CWO NPs (170 ± 10 nm hydrodynamic diameter) produce a higher CT contrast (by a factor of about 2) than commercial iodine-based radiocontrast agents (e.g., Iohexol) at identical molar concentrations of W or I atoms. PEG-PLA-coated CWO NPs are chemically stable and completely nontoxic. It was confirmed that the maximum tolerated dose (MTD) of this material in mice is significantly higher (250 ± 50 mg per kg body weight following a single intravenous (IV) administration) than, for instance, commercially available dextran-coated iron oxide nanoparticles that are currently used clinically as MRI contrast agents (MTD in mice ≈ 168 mg/kg per dose IV). IV-injected PEG-PLA/CWO NPs caused no histopathologic damage in major excretory organs (heart, liver, lungs, spleen, and kidney). When an IV dose of 100 mg/kg was given to mice, the blood circulation half-life was measured to be about 4 h, and more than 90% of the NPs were cleared from the mice within 24 h via the renal and hepatobiliary systems. When intratumorally administered, PEG-PLA-coated CWO NPs showed complete retention in a tumor-bearing mouse model (measurements were made up to 1 week). These results suggest that PEG-PLA-coated CWO NPs are promising materials for use in CT contrast.

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Section: Discussionsupporting

confidence: 58%

Nontoxic Formulations of Scintillation Nanocrystals for Use as X-ray Computed Tomography Contrast Agents

et al. 2016

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“…Overall, the cell viability seems to be more affected in the first 24 h of nanoparticles exposure, as compared with 48 h. These findings may indicate cytotoxicity with a certain threshold-like concentration-dependent pattern (100 μg/mL W-NPs), for both sizes of nanoparticles. Our result is in agreement with other investigations on W based NPs that identified a threshold NPs concentration of 100 μg/mL bellow which nanoparticles were found nontoxic [ 20 , 21 , 25 ].…”

Section: Discussionsupporting

confidence: 93%

“…Although research into the cytotoxic effect of W dust is already ongoing, the mechanisms and harmful effects are not yet fully and thoroughly known and these studies are in a limited number. W has been studied under different forms such as tungsten carbide (WC) alloys doped with cobalt (WC–Co) [ [12] , [13] , [14] , [15] , [16] , [17] ], sodium tungstate (Na 2 WO 4 ) [ 18 , 19 ], W oxide nanoparticles (WO 3 NPs) [ [20] , [21] , [22] , [23] , [24] ] and metallic W [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of the cytotoxic effect of two different sizes ITER-like tungsten nanoparticles on human dermal fibroblasts

Carpen

Acasandrei

Acsente

et al. 2023

Heliyon

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“…W-alloys) (Wasel and Freeman, 2018). Tungsten has also been found to bioaccumulate in plants (Pyatt and Pyatt, 2004;Wilson and Pyatt, 2006;Lin et al, 2014), is able to be transferred to higher trophic levels , and has found to be toxic to other organisms including earthworms, (Inouye et al, 2006), snails Allison et al, 2016), fish (Kühnel et al, 2009;, and rats (Turkez et al, 2014).…”

Section: Tungsten Toxicity and Ecotoxicitymentioning

confidence: 99%

Factors Controlling Tungsten Mobility in W-Cu Skarn Tailings at the Cantung Mine, Northwest Territories, Canada

Kazamel¹,

Jamieson²,

Leybourne³

et al. 2019

Geological Society of America Abstracts With Programs

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The first of many thank-you's goes to my supervisors, Heather Jamieson and Matt Leybourne, for their mentorship, guidance, and patience over the past few years. I am extremely privileged, honored, and proud to be part of the Jamieson Clan and the QFIR family, and couldn't have asked for a more wonderful group of people to develop my career as a geochemist with. The Winter Wonderlands, defense parties, and Grad Club beer discussions were some of the highlights of my time at Queen's. Heather, I fell in love with the north during our trip to Cantung, and our long, beautiful drives to and from the mine will be forever in my mind. Thank you so much for giving me this opportunity, and for the opportunities that have stemmed as a result from completing this thesis. Matt, your contributions to this thesis are innumerable. Having access to world class analytical facilities at QFIR, and same-day access to a worldclass geochemist for answers to my (often redundant) questions has been invaluable. Both of you held infinite patience during periods when I was low, and I honestly don't think my thesis would have been completed without your understanding. It has been a pleasure working with both of you. This thesis is dedicated to Kurt Kyser, who took me under his wing that one fateful summer in Kingston. After expressing my interest in geochemistry, Kurt offered me a summer student position at QFIR and exposed me to my first taste of analytical and field work, which lead to me completing an undergraduate thesis under his supervision. Kurt's enthusiasm for science, his lust for life, and his dedication to QFIR inspired me to pursue a career in geochemistry, and even more so to pursue a life of passion. I wish you could have reviewed this thesis, that we could've share the excitement of the results, or even just to have seen you shake your head and say, "nah". This thesis wouldn't be possible without Hendrik Falck, the Cantung connoisseur. Thank you for assisting with field work, and for sharing your big-brain knowledge of the Cantung deposit, of the history of the mine, and of the physiography of the Flat River valley. A brewpub visit in is order during my next visit to Yellowknife! A very special thank-you is in order for Dan Layton-Matthews, who first sparked v my interest in geochemistry via ternary diagrams in second year petrology, and another to Noel James for our discussions about big-picture global issues, science and creativity, and for just being a rad dude. Guy Narbonne, thank you for taking care of me when I got sick in Namibia, and for expressing not even the slightest discontent about missing part of the Etosha safari. Rob Harrap, I don't know how to express my thanks to you. We've had so many discussions throughout my undergraduate and master's degrees about anything and everything, but the ones where I came in distressed and left with some clarity are undoubtedly the most important.To all of the QFIR family, thank you for all of the analytical assistance, the laughs, and the wine over the years. April, your bubbli...

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The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Abstract: Tungsten (VI) oxide (WO 3 ) nanoparticles (NPs

Cited by 26 publications

References 61 publications

Nontoxic Formulations of Scintillation Nanocrystals for Use as X-ray Computed Tomography Contrast Agents

Nontoxic Formulations of Scintillation Nanocrystals for Use as X-ray Computed Tomography Contrast Agents

In vitro analysis of the cytotoxic effect of two different sizes ITER-like tungsten nanoparticles on human dermal fibroblasts

Factors Controlling Tungsten Mobility in W-Cu Skarn Tailings at the Cantung Mine, Northwest Territories, Canada

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