The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study

Trape, Jean‐François; Tall, Adama; Sokhna, Cheikh; Ly, Alioune Badara; Diagne, Nafissatou; Ndiath, Ousmane; Mazenot, Catherine; Richard, Vincent; Badiane, Alpha; Dieye-Ba, Fambaye; Faye, Joseph; Ndiaye, Gora; Sarr, Fatoumata Diène; Roucher, Clémentine; Bouganali, Charles; Basséne, Hubert; Touré-Baldé, Aïssatou; Roussilhon, Christian; Perraut, Ronald; Spiegel, André; Sarthou, Jean-Louis; Silva, Luiz Pereira da; Mercereau‐Puijalon, Odile; Druilhe, Pierre; Rogier, Christophe

doi:10.1016/s1473-3099(14)70712-1

Cited by 157 publications

(188 citation statements)

References 28 publications

Supporting

Mentioning

176

Contrasting

Unclassified

Order By: Relevance

“…The study was carried out in Ndiop, a Senegalese village with seasonal transmission where a long-term longitudinal survey designed to study acquisition and maintenance of natural immunity has been carried out over more than 20 years [19–22]. The project protocol and objectives were carefully explained to the assembled villagers, and informed consent was obtained from all participants or their parents or guardians on a voluntary consent form written in both French and in Wolof, the local language.…”

Section: Methodsmentioning

confidence: 99%

“…All other procedures were as described [24, 25]. Each plate included two positive controls: a pool of human Immune IgG (kind gift from Prof M Hommel) and a pool of 30 sera collected in 2000–2 from immune adults from Dielmo, a holoendemic village located 5 km apart from Ndiop [21, 22]. The negative naïve control was a pool of non-immune sera from blood donors living in France.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

Perraut

Richard

Varela

et al. 2014

Malar J

Self Cite

View full text Add to dashboard Cite

BackgroundNumerous Plasmodium falciparum antigens elicit humoral responses in humans living in endemic areas. Use of multiplex assays is a convenient approach to monitor the antibody response against multiple antigens, but to integrate multiplex assay-derived data with datasets, generated previously using ELISA, comparative studies are needed. This work compares antibody responses to two P. falciparum antigens monitored using both technologies.MethodsThe IgG response against the merozoite surface protein-1 PfMSP1p19 and the PF13-DBL1α1 domain of the P. falciparum Erythrocyte Membrane Protein1, expressed by the rosette-forming parasite 3D7/PF13 (PF13), was investigated using ELISA and a MAGPIX®-Luminex duplex assay. Archived plasma samples collected before the rainy season from 217 villagers living in Ndiop, a Senegalese meso-endemic setting, were studied. ROC analysis was used to define the optimal antibody measure readout. Association of antibody levels with protection against clinical malaria was analysed using Poisson regression in a retrospective study from active case detection records performed during the 5.5-month transmission season that followed blood sampling.ResultsThere was a strong positive correlation (P <10-3) between ELISA and MAGPIX®-Luminex-MFI (median fluorescence intensity) values for antibody to PfMSP1p19 (rho = 0.78) and PF13-DBL1α1 (rho = 0.89), with a similar degree of concordance in all age groups. Antibody levels to both antigens were high but displayed a different age-associated pattern. Independent age-adjusted Poisson regression analysis showed a significant association with protection only for IgG responses to MSP1p19 (P <0.01 RR = 0.71 [0.53-0.93]) measured by ELISA.ConclusionThe individual ELISA and duplex-MAGPIX assays provide a concordant evaluation of age-associated antibody responses to MSP1p19 and PF13-DBL1α1, irrespective of the formulation of antibody levels (values, ratios or ROC-adjusted figures) but do diverge with regard to the association of antibody levels with clinical protection in age-adjusted models. This may reflect incomplete overlap of the epitopes presented in the two formats. Further development for multiplex assessment of antibody responses to a larger panel of antigens with the robust and cost effective MAGPIX®-Luminex technology is warranted.Electronic supplementary materialThe online version of this article (doi:10.1186/1475-2875-13-410) contains supplementary material, which is available to authorized users.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

Perraut

Richard

Varela

et al. 2014

Malar J

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scaled-up standard containment activities have helped to control malaria in a range of regions and may have contributed to the global decline of malaria prevalence over the last 10 years [130][131][132][133]. This slow strangulation of parasite populations results in the selection of the most resistant parasite strains, which manage to survive despite control efforts [134].…”

Section: Back-burn: Targeted Malaria Eliminationmentioning

confidence: 99%

Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance

Seidlein

Dondorp

2015

Expert Review of Anti-infective Therapy

101

View full text Add to dashboard Cite

The emergence and spread of antimalarial resistance has been a major liability for malaria control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic consequences for people in malaria-endemic regions, particularly in sub-Saharan Africa. The recent emergence of artemisinin-resistant P. falciparum strains is of highest concern. Current efforts to contain artemisinin resistance have yet to show success. In the absence of more promising plans, it has been suggested to eliminate falciparum malaria from foci of artemisinin resistance using a multipronged approach, including mass drug administrations. The use of mass drug administrations is controversial as it increases drug pressure. Based on current knowledge it is difficult to conceptualize how targeted malaria elimination could contribute to artemisinin resistance, provided a full treatment course is ensured.

show abstract

“…Malaria control programs in Dielmo have not only led to a drastic reduction of disease prevalence [22] but also to the uncovering of other causes of fever presumably believed as malaria. These febrile episodes may be caused by other infectious pathogens including bacteria, parasites or viruses [23,24].…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of febrile patients reveals unnoticed epidemic of zika fever in Dielmo, Senegal, 2000

Ba¹,

Loucoubar²,

Faye³

et al. 2018

Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study

Cited by 157 publications

References 28 publications

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

Comparative analysis of IgG responses to Plasmodium falciparum MSP1p19 and PF13-DBL1α1 using ELISA and a magnetic bead-based duplex assay (MAGPIX®-Luminex) in a Senegalese meso-endemic community

Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance

Retrospective analysis of febrile patients reveals unnoticed epidemic of zika fever in Dielmo, Senegal, 2000

Contact Info

Product

Resources

About