The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Forster, Roy; Bode, Ger D.; Ellegaard, Lars; Laan, Jan van der

doi:10.1016/j.vascn.2010.05.008

Cited by 75 publications

(66 citation statements)

References 11 publications

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“…Pigs were found to exhibit spontaneous vertebral fracture and their rates of bone removal and deposition (trabecular and cortical bones) are similar to humans although porcine bone remodels slightly faster than human bone [152,155,156]. Limitations for the use of NHP in regulatory toxicology studies have opened discussions on the suitability of using minipigs in drug development studies [157]. Recently, it was shown that minipigs are comparable to NHP in immunogenicity testing [158,159] and their liver metabolism is similar to that of humans [160].…”

Section: Pigmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

126

116

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Section: Pigmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

126

116

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“…Miniature pigs such as Göttingen are well known as one of the ideal experimental animals because of their similarities to humans including skin, cardiovascular, respiratory, metabolic, gastrointestinal systems and so on Forster et al, 2010;Laursen et al, 2011;Svendsen, 2006). However, it has been difficult to use not only regular pigs but also miniature pigs for obtaining in vivo proof, since they require much larger dose of a test article than in dogs and monkeys which have been used as non-rodent experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of <i>microminipig</i> as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies

et al. 2017

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-We tried to establish the halothane-anesthetized microminipigs as an alternative animal model for non-clinical toxicity and/or safety pharmacology studies. In order to characterize the halothane-anesthetized microminipigs, we firstly clarified the effects of halothane anesthesia on their cardiovascular system (n = 5). Then, we examined the cardiovascular effects of dl-sotalol in doses of 0.1, 0.3 and 1 mg/kg, i.v. on the halothane-anesthetized microminipigs (n = 6). Induction of the halothane anesthesia by itself prolonged the QT interval as well as QTcF, suggesting that the halothane anesthesia can reduce the cardiac repolarization reserve in microminipigs like in dogs. dl-Sotalol showed more potent negative chronotropic, dromotropic and hypotensive effects together with repolarization delay in microminipigs than in dogs, although each cardiovascular response to dl-sotalol was directionally similar between them, suggesting greater basal sympathetic tone and/or smaller volume of distribution of the drug in microminipigs than in dogs. Analyses of proarrhythmic surrogate markers indicate that T peak -T end and short-term variability of QT interval may be more sensitive to detect the dl-sotalol-induced direct electrophysiological changes in microminipigs than in dogs, but its reverse will be true for J-T peak c. Thus, these results may help better understand the drug-induced cardiovascular responses in microminipigs.

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“…Growing concern about use of dogs and nonhuman primates in biomedical research have fueled increasing interest in using the minipig on a more routine basis in drug development (Forster et al 2010). There are several strains of minipigs; the Göt-tingen minipig is among the most studied.…”

Section: Minipigsmentioning

confidence: 99%

Nontraditional Applications in Clinical Pathology

Jordan

Tripathi

et al. 2014

Toxicol Pathol

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Most published reviews of preclinical toxicological clinical pathology focus on the fundamental aspects of hematology, clinical chemistry, coagulation, and urinalysis in routine toxicology animal species, for example, rats, mice, dogs, and nonhuman primates. The objective of this continuing education course was to present and discuss contemporary examples of nonroutine applications of clinical pathology endpoints used in the drug development setting. Area experts discussed bone turnover markers of laboratory animal species, clinical pathology of pregnant and growing laboratory animals, clinical pathology of nonroutine laboratory animal species, and unique applications of the Siemens Advia 1 hematology analyzer. This article is a summary based on a presentation given at the 31st Annual Symposium of the Society of Toxicologic Pathology, during the Continuing Education Course titled ''Nontraditional Applications of Clinical Pathology in Drug Discovery and Preclinical Toxicology.''

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The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Cited by 75 publications

References 11 publications

The rational use of animal models in the evaluation of novel bone regenerative therapies

The rational use of animal models in the evaluation of novel bone regenerative therapies

Pharmacological characterization of <i>microminipig</i> as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies

Nontraditional Applications in Clinical Pathology

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